spironolactone has been researched along with Death, Sudden in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethoprim-sulfamethoxazole increases the risk of hyperkalemia when used with spironolactone." | 3.81 | Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone. ( Antoniou, T; Gomes, T; Hollands, S; Juurlink, DN; Macdonald, EM; Mamdani, MM, 2015) |
| "Emphasis is on the arrhythmia component and the complex interrelationships of critical electrolytes and pathophysiologic factors that can lead to sudden cardiac death." | 1.28 | Short- and long-term mechanisms of sudden cardiac death in congestive heart failure. ( Helfant, RH, 1990) |
| "Additional evidence suggests that sudden death may occasionally result from this VEA." | 1.27 | Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients. ( Holland, OB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Antoniou, T | 1 |
| Hollands, S | 1 |
| Macdonald, EM | 1 |
| Gomes, T | 1 |
| Mamdani, MM | 1 |
| Juurlink, DN | 1 |
| Ananthakrishnan, S | 1 |
| Vergaro, G | 1 |
| Emdin, M | 1 |
| Iervasi, A | 1 |
| Zyw, L | 1 |
| Gabutti, A | 1 |
| Poletti, R | 1 |
| Mammini, C | 1 |
| Giannoni, A | 1 |
| Fontana, M | 1 |
| Passino, C | 1 |
| SJOBERG, WE | 1 |
| KREISLE, JE | 1 |
| Helfant, RH | 1 |
| Holland, OB | 1 |
6 other studies available for spironolactone and Death, Sudden
| Article | Year |
|---|---|
Trimethoprim-sulfamethoxazole and risk of sudden death among patients taking spironolactone.
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Case-Control Studies; Confiden | 2015 |
ACP Journal Club. Trimethoprim-sulfamethoxazole was linked to sudden death in older patients using spironolactone.
Topics: Anti-Infective Agents, Urinary; Death, Sudden; Female; Humans; Hyperkalemia; Male; Mineralocorticoid | 2015 |
Prognostic value of plasma renin activity in heart failure.
Topics: Aged; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bioma | 2011 |
Hyperkalemia and sudden death during Spironolactone (Aldactone) therapy.
Topics: Death, Sudden; Humans; Hyperkalemia; Kidney Diseases; Liver Diseases; Spironolactone | 1962 |
Short- and long-term mechanisms of sudden cardiac death in congestive heart failure.
Topics: Aldosterone; Arrhythmias, Cardiac; Death, Sudden; Diuretics; Heart Failure; Humans; Magnesium; Potas | 1990 |
Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients.
Topics: Amiloride; Arrhythmias, Cardiac; Death, Sudden; Diuretics; Humans; Hypertension; Hypokalemia; Magnes | 1986 |