spironolactone has been researched along with Cystic Fibrosis in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Emrich, HM | 1 |
| Stoll, E | 1 |
| Friolet, B | 1 |
| Colombo, JP | 1 |
| Rossi, E | 1 |
| Richterich, R | 1 |
| Qiu, W | 1 |
| Laheri, A | 1 |
| Leung, S | 1 |
| Guggino, SE | 1 |
| Storm, W | 1 |
| Knowles, MR | 1 |
| Gatzy, JT | 1 |
| Boucher, RC | 1 |
4 other studies available for spironolactone and Cystic Fibrosis
| Article | Year |
|---|---|
Excretion of different substances in the sweat of children with cystic fibrosis and controls.
Topics: Aldosterone; Calcium; Child; Chlorides; Creatinine; Cystic Fibrosis; Humans; Lactates; Male; Sodium; | 1967 |
Hormones increase mRNA of cyclic-nucleotide-gated cation channels in airway epithelia.
Topics: Animals; Bronchi; Cell Line; Cell Line, Transformed; Cyclic Nucleotide-Gated Cation Channels; Cystic | 2000 |
[Respiratory insufficiency in mucoviscidosis. Pathophysiologic aspects of conservative drug therapy].
Topics: Acid-Base Equilibrium; Child; Combined Modality Therapy; Cystic Fibrosis; Drug Therapy, Combination; | 1989 |
Aldosterone metabolism and transepithelial potential difference in normal and cystic fibrosis subjects.
Topics: Adult; Aldosterone; Canrenone; Cystic Fibrosis; Electrophysiology; Epithelium; Female; Humans; Male; | 1985 |