spironolactone has been researched along with Cushing Syndrome in 32 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The addition of spironolactone to her previous medications controlled and normalized hypertension, hypokalemia, and hormonal abnormalities within 4 months." | 7.76 | Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--. ( Harada, E; Mizuno, Y; Morikawa, Y; Nakagawa, H; Saito, Y; Semba, F; Yasue, H; Yoshimura, M, 2010) |
| " The addition of spironolactone to her previous medications controlled and normalized hypertension, hypokalemia, and hormonal abnormalities within 4 months." | 3.76 | Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--. ( Harada, E; Mizuno, Y; Morikawa, Y; Nakagawa, H; Saito, Y; Semba, F; Yasue, H; Yoshimura, M, 2010) |
| "Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female." | 2.61 | Hirsutism in Women. ( Bain, J; Matheson, E, 2019) |
| "Adrenal cortical carcinoma is a rare endocrine tumor, and complete surgical resection is the only potentially curative treatment." | 2.41 | Adrenal cortical carcinoma. ( Boushey, RP; Dackiw, AP, 2001) |
| "Only when the Cushing syndrome has been confirmed clinically and biochemically, should an imaging procedure be performed." | 1.31 | [Secondary forms of hypertension. 5. Hypertension caused by Cushing syndrome and Conn's disease]. ( Füessl, HS, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (68.75) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, K | 1 |
| Ou, X | 1 |
| Huang, X | 1 |
| Lan, Q | 1 |
| Matheson, E | 1 |
| Bain, J | 1 |
| Sedhom, R | 1 |
| Hu, S | 1 |
| Ohri, A | 1 |
| Infantino, D | 1 |
| Lubitz, S | 1 |
| Bailey, MA | 1 |
| Mullins, JJ | 1 |
| Kenyon, CJ | 1 |
| Harada, E | 1 |
| Yasue, H | 1 |
| Mizuno, Y | 1 |
| Morikawa, Y | 1 |
| Nakagawa, H | 1 |
| Semba, F | 1 |
| Yoshimura, M | 1 |
| Saito, Y | 1 |
| Katayama, A | 1 |
| Otsuka, F | 1 |
| Tanabe, K | 1 |
| Tsukamoto, N | 1 |
| Yamanaka, R | 1 |
| Matsumoto, Y | 1 |
| Nasu, Y | 1 |
| Makino, H | 1 |
| BLOCH, J | 1 |
| FUKUCHI, S | 3 |
| SHIOJI, R | 1 |
| HANATA, M | 2 |
| DEMURA, H | 2 |
| ABE, S | 1 |
| TAKAHASHI, H | 1 |
| GOTO, K | 2 |
| GEOKAS, MC | 1 |
| CHUN, JY | 1 |
| DINAN, JJ | 1 |
| BECK, IT | 1 |
| Oosterhuis, JK | 1 |
| van den Berg, G | 1 |
| Monteban-Kooistra, WE | 1 |
| Ligtenberg, JJ | 1 |
| Tulleken, JE | 1 |
| Meertens, JH | 1 |
| Zijlstra, JG | 1 |
| Maebashi, M | 2 |
| Yoshinaga, K | 2 |
| Tragl, KH | 1 |
| Aron, DC | 1 |
| Tyrrell, JB | 1 |
| Fitzgerald, PA | 1 |
| Findling, JW | 1 |
| Forsham, PH | 1 |
| Hofmockel, G | 1 |
| Heimbach, D | 1 |
| Bussen, D | 1 |
| Reincke, M | 1 |
| Frohmüller, HG | 1 |
| Füessl, HS | 1 |
| Boushey, RP | 1 |
| Dackiw, AP | 1 |
| Horký, K | 2 |
| Gregorová, I | 2 |
| Tomsová, Z | 1 |
| Vancura, J | 1 |
| Silinková-Málková, E | 1 |
| Koelmeyer, TD | 1 |
| Woods, WP | 1 |
| Wortsman, J | 1 |
| Soler, NG | 1 |
| Mahood, JM | 1 |
| Schrub, JC | 1 |
| Courtois, H | 1 |
| Melby, JC | 2 |
| Powell, D | 1 |
| Nakajima, K | 1 |
| Takenouchi, T | 1 |
| Nishisato, K | 1 |
| Kaplan, NN | 1 |
| László, F | 1 |
| Durszt, F | 1 |
| Petri, G | 1 |
| Miura, K | 1 |
| Katsushima, I | 1 |
| Gall, G | 1 |
| Usher, P | 1 |
| Klein, R | 1 |
| Guinet, P | 1 |
| Mornex, R | 1 |
| Revol, A | 1 |
| Bertrand, J | 1 |
| Veyrat, A | 1 |
| Dorsit, G | 1 |
| Küchel, O | 1 |
| Jiránková, J | 1 |
| Matys, Z | 1 |
| Radó, JP | 1 |
| Takó, J | 1 |
| Hammer, C | 1 |
| Szilágyi, L | 1 |
6 reviews available for spironolactone and Cushing Syndrome
| Article | Year |
|---|---|
Hirsutism in Women.
Topics: Adrenal Hyperplasia, Congenital; Androgen Antagonists; Antineoplastic Agents, Hormonal; Contraceptiv | 2019 |
Adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Algorithms; Antineoplastic Agents; Carcinoma; Chemot | 2001 |
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldoster | 1971 |
Clinical significance of circulating hormonal substances.
Topics: Adrenocorticotropic Hormone; Calcium; Circadian Rhythm; Cross Reactions; Cushing Syndrome; Glycoprot | 1974 |
Adrenal causes of hypertension.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Carci | 1974 |
[Problems in the surgical treatment of Cushing's disease. Our experience with bilateral adrenalectomy].
Topics: Adolescent; Adrenalectomy; Adult; Child; Corticosterone; Cortisone; Cushing Syndrome; Female; Follow | 1974 |
26 other studies available for spironolactone and Cushing Syndrome
| Article | Year |
|---|---|
Adrenocortical hypofunction with simultaneous primary aldosteronism: A case report.
Topics: Adrenal Insufficiency; Aged; Aldosterone; Cushing Syndrome; Female; Humans; Hydrocortisone; Hyperald | 2019 |
Symptomatic Cushing's syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report.
Topics: Aged; Antineoplastic Agents, Hormonal; Cushing Syndrome; Disease Progression; Fatal Outcome; Female; | 2016 |
Mineralocorticoid and glucocorticoid receptors stimulate epithelial sodium channel activity in a mouse model of Cushing syndrome.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Cushing Syndrome; Disease Models, Animal; Epit | 2009 |
Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Ag | 2010 |
Unexpected occurrence of adrenal Cushing's syndrome in a patient with systemic lupus erythematosus.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adult; Angiomyolipoma; Antihyperten | 2011 |
[Cushing's syndrome, adiposity, hyperaldosteronism. Effect of spirolactone].
Topics: Adiposity; Cushing Syndrome; Humans; Hyperaldosteronism; Obesity; Spironolactone | 1963 |
THE DIAGNOSTIC IMPLICATION OF RESTRICTION OF SALT INTAKE AND ADMINISTRATION OF VARIOUS DRUGS IN PRIMARY ALDOSTERONISM.
Topics: Aldosterone; Biomedical Research; Cushing Syndrome; Desoxycorticosterone; Diagnosis, Differential; D | 1964 |
THE RELATIONSHIP BETWEEN VASCULAR REACTIVITY AND EXTRACELLULAR POTASSIUM.
Topics: Angiotensins; Blood Chemical Analysis; Blood Pressure; Blood Vessels; Body Weight; Chlorothiazide; C | 1965 |
ISLET-CELL CARCINOMA (ZOLLINGER-ELLISON SYNDROME) WITH FULMINATING ADRENOCORTICAL HYPERFUNCTION AND HYPOKALEMIA.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenalectomy; Adrenocortical Hyper | 1965 |
Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome.
Topics: Cushing Syndrome; Disease Progression; Fatal Outcome; Female; Humans; Ketoconazole; Middle Aged; Mif | 2007 |
Changes in plasma renin activity after administration of spironolactone.
Topics: Adolescent; Adult; Aortic Coarctation; Blood Pressure; Cushing Syndrome; Female; Glomerulonephritis; | 1967 |
[Iatrogenic and environmentally caused diseases of the endocrine system in the aged].
Topics: Aged; Cortisone; Cushing Syndrome; Digitalis Glycosides; Endocrine System Diseases; Environmental Ex | 1983 |
Cushing's syndrome: problems in diagnosis.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult; | 1981 |
[Surgical interventions of the adrenal gland. Diagnosis and results of treatment].
Topics: Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Adenoma; | 1994 |
[Secondary forms of hypertension. 5. Hypertension caused by Cushing syndrome and Conn's disease].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Algorithms; Cushing Sy | 2002 |
Plasma concentration of aldosterone, 18-hydroxy-deoxycorticosterone and cortisol in adrenal veins of patients with low-renin hypertension.
Topics: 18-Hydroxydesoxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropi | 1977 |
Carcinoma of the lung presenting as Cushing's syndrome.
Topics: Aminoglutethimide; Carcinoma, Bronchogenic; Cortisone; Cushing Syndrome; Cyclophosphamide; Diagnosis | 1977 |
Mitotane. Spironolactone antagonism in Cushing's syndrome.
Topics: Aged; Cushing Syndrome; Diarrhea; Female; Humans; Hypokalemia; Mitotane; Nausea; Spironolactone | 1977 |
Alcohol-induced Cushingoid syndrome: a false diagnosis.
Topics: Alcoholism; Cushing Syndrome; Diagnostic Errors; Heart Failure; Humans; Male; Middle Aged; Spironola | 1977 |
[Letter: Idiopathic hemochromatosis and Cushing's disease].
Topics: Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Female; Hemochromatosis; Humans; Mitotane; Sp | 1975 |
Plasma aldosterone in essential hypertension with low renin activity.
Topics: Aldosterone; Body Weight; Corticosterone; Cushing Syndrome; Furosemide; Humans; Hydrochlorothiazide; | 1974 |
Suppressed plasma renin activity in in hypertensive patients--its evaluation for the diagnosis of primary aldosteronism.
Topics: Aldosterone; Cushing Syndrome; Diet, Sodium-Restricted; Glomerulonephritis; Humans; Hydrochlorothiaz | 1969 |
Effects of aldosterone and cortisol on human erythrocyte Na efflux.
Topics: Aldosterone; Biological Transport, Active; Cushing Syndrome; Erythrocytes; Humans; Hydrocortisone; H | 1971 |
[2 cases of Cushing's disease with a hypokalemic alkalosis syndrome].
Topics: Adrenalectomy; Adult; Alkalosis; Calcium; Cushing Syndrome; Female; Humans; Hypokalemia; Metyrapone; | 1967 |
[Inhibitions of steroid biosynthesis in the adrenal gland by aminogluthetimide (Elipten CIBA) and its practical significance].
Topics: 17-Ketosteroids; Adrenal Glands; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Cushing Synd | 1969 |
[On the effect of aldosterone and aldactone A on various segments of kidney tubules in Cushing's syndrome with polyuria].
Topics: Aldosterone; Cushing Syndrome; Desoxycorticosterone; Humans; Hydrocortisone; Kidney Tubules; Polyuri | 1965 |