spironolactone has been researched along with Crohn Disease in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality." | 5.38 | Spironolactone and colitis: increased mortality in rodents and in humans. ( Gillespie, BW; Govani, SM; Higgins, PD; Johnson, LA; Joyce, JC; Waljee, AK, 2012) |
| "Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality." | 1.38 | Spironolactone and colitis: increased mortality in rodents and in humans. ( Gillespie, BW; Govani, SM; Higgins, PD; Johnson, LA; Joyce, JC; Waljee, AK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, LA | 1 |
| Govani, SM | 1 |
| Joyce, JC | 1 |
| Waljee, AK | 1 |
| Gillespie, BW | 1 |
| Higgins, PD | 1 |
1 other study available for spironolactone and Crohn Disease
| Article | Year |
|---|---|
Spironolactone and colitis: increased mortality in rodents and in humans.
Topics: Animals; Clostridioides difficile; Clostridium Infections; Colitis; Crohn Disease; Female; Fibrosis; | 2012 |