spironolactone has been researched along with Coronary Disease in 29 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On long term evaluation in an open design (Phase II), wherein Phase I participants continued Terminalia Arjuna in fixed dosage (500 mg 8-hourly) in addition to flexible diuretic, vasodilator and digitalis dosage for 20-28 months (mean 24 months) on outpatient basis, patients showed continued improvement in symptoms, signs, effort tolerance and NYHA Class, with improvement in quality of life." | 2.68 | Salutary effect of Terminalia Arjuna in patients with severe refractory heart failure. ( Bharani, A; Bhargava, KD; Ganguly, A, 1995) |
| "Spironolactone was less effective, and aldosterone tended to exert opposite effects on coronary artery structure after angioplasty." | 1.31 | Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries. ( Bobik, A; Funder, J; Kanellakis, P; Ramsey, D; Ward, MR, 2001) |
| "Aldosterone treatment was associated with a decrease in renin activity and a non-significant increase in mean arterial pressure." | 1.29 | Neointimal thickening after balloon denudation is enhanced by aldosterone and inhibited by spironolactone, and aldosterone antagonist. ( Bauters, C; Bertrand, ME; Dupuis, B; Hamon, M; Lablanche, JM; McFadden, EP; Racadot, A; Van Belle, E; Wernert, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (65.52) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rickenbacher, P | 1 |
| Williams, ES | 1 |
| Miller, JM | 1 |
| Rocha, R | 1 |
| Martin-Berger, CL | 1 |
| Yang, P | 1 |
| Scherrer, R | 1 |
| Delyani, J | 1 |
| McMahon, E | 1 |
| Young, MJ | 1 |
| Moussa, L | 1 |
| Dilley, R | 1 |
| Funder, JW | 1 |
| BARNETT, AJ | 1 |
| BAUMGARTEN, A | 1 |
| BRANDSTATER, M | 1 |
| LOCKWOOD, CH | 1 |
| NICHOLLS, DM | 1 |
| LEWIS, JA | 1 |
| TROOP, VL | 1 |
| JOHNSTON, LC | 1 |
| GRIEBLE, HG | 1 |
| SCHOENBERGER, JA | 1 |
| FULLER, JB | 1 |
| SETTEL, E | 1 |
| Lenz, T | 1 |
| Waldorff, S | 1 |
| Berning, J | 1 |
| Buch, J | 1 |
| Steiness, E | 1 |
| Barr, CS | 1 |
| Lang, CC | 1 |
| Hanson, J | 1 |
| Arnott, M | 1 |
| Kennedy, N | 1 |
| Struthers, AD | 1 |
| Bharani, A | 1 |
| Ganguly, A | 1 |
| Bhargava, KD | 1 |
| Van Belle, E | 1 |
| Bauters, C | 1 |
| Wernert, N | 1 |
| Hamon, M | 1 |
| McFadden, EP | 1 |
| Racadot, A | 1 |
| Dupuis, B | 1 |
| Lablanche, JM | 1 |
| Bertrand, ME | 1 |
| Armstrong, PW | 1 |
| Ward, MR | 1 |
| Kanellakis, P | 1 |
| Ramsey, D | 1 |
| Funder, J | 1 |
| Bobik, A | 1 |
| Wilhelmsen, L | 1 |
| Berglund, G | 1 |
| Sannerstedt, R | 1 |
| Hansson, L | 1 |
| Andersson, O | 1 |
| Sievertsson, R | 1 |
| Wikstrand, J | 1 |
| Drozdova, ES | 1 |
| Vinogradov, AV | 4 |
| Sycheva, IM | 4 |
| Zhuravleva, IA | 1 |
| Zamotaev, IP | 1 |
| Kabakov, AI | 1 |
| Perchikova, GE | 1 |
| Tsibekmakher, TD | 1 |
| Sigurd, B | 1 |
| Olesen, KH | 1 |
| Wennevold, A | 1 |
| Houston, MC | 1 |
| Johnston, PE | 1 |
| Stewart, DE | 1 |
| Ikram, H | 1 |
| Espiner, EA | 1 |
| Nicholls, MG | 1 |
| Kilcoyne, MM | 1 |
| Thomson, GE | 1 |
| Branche, G | 1 |
| Williams, M | 1 |
| Garnier, C | 1 |
| Chiles, B | 1 |
| Soland, T | 1 |
| Fleming, JS | 1 |
| Speranskaia, NV | 2 |
| Kramer, AA | 1 |
| Ignatova, TA | 2 |
| Krater, AA | 1 |
| Kuz'mina, AE | 1 |
| Kiseleva, ZM | 1 |
| Yasui, H | 1 |
2 reviews available for spironolactone and Coronary Disease
| Article | Year |
|---|---|
[Heart failure with "mid-range" ejection fraction: a new clinical entity?]
Topics: Aged; Aminobutyrates; Benzimidazoles; Biomarkers; Biphenyl Compounds; Comorbidity; Coronary Disease; | 2018 |
Essential hypertension: new insights and controversies in treatment with diuretics.
Topics: Amiloride; Antihypertensive Agents; Blood Pressure; Coronary Disease; Diuretics; Dose-Response Relat | 1986 |
7 trials available for spironolactone and Coronary Disease
| Article | Year |
|---|---|
Results from late-breaking clinical trial sessions at the American College of Cardiology 51st Annual Scientific Session.
Topics: Adenosine; Angioplasty, Balloon, Coronary; Anti-Arrhythmia Agents; Antihypertensive Agents; Atherect | 2002 |
Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease.
Topics: Aged; Blood Pressure; Body Weight; Coronary Disease; Depression, Chemical; Digoxin; Drug Interaction | 1982 |
Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease.
Topics: Aged; Animals; Coronary Disease; Double-Blind Method; Drug Therapy, Combination; Female; Heart; Hear | 1995 |
Salutary effect of Terminalia Arjuna in patients with severe refractory heart failure.
Topics: Adult; Aged; Cardiomyopathy, Dilated; Chemotherapy, Adjuvant; Chronic Disease; Coronary Disease; Cro | 1995 |
[Fluid redistribution between the extracellular medium and the cells in the diuretic therapy of cardiac insufficiency].
Topics: Adult; Aged; Body Water; Cardiac Glycosides; Clinical Trials as Topic; Coronary Disease; Diuretics; | 1975 |
[Comparative evaluation of the effectiveness of diuretics].
Topics: Adolescent; Adult; Aged; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Diuresis; Diur | 1976 |
The supra-additive natriuretic effect addition of bendroflumethiazide and bumetanide in congestive heart failure. Permutation trial tests in patients in long-term treatment with bumetanide.
Topics: Adult; Bendroflumethiazide; Benzoates; Butylamines; Chlorides; Clinical Trials as Topic; Coronary Di | 1975 |
20 other studies available for spironolactone and Coronary Disease
| Article | Year |
|---|---|
Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
Topics: Adrenalectomy; Aldosterone; Angiotensin II; Animals; Body Weight; Coronary Disease; Coronary Vessels | 2002 |
Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Animals; Blood Pressure; Carbenoxolone; Cardiomegaly; Coronar | 2003 |
OBSERVATIONS ON TRIAMTERENE--A NEW DIURETIC.
Topics: Chlorides; Chlorothiazide; Coronary Disease; Craniocerebral Trauma; Diuretics; Edema; Geriatrics; He | 1963 |
THE DIURETIC EFFECT OF TRIAMTERENE.
Topics: Blood Chemical Analysis; Coronary Disease; Creatine; Creatinine; Diuretics; Heart Failure; Hypertens | 1964 |
TREATMENT OF ARTERIAL HYPERTENSIVE DISEASE WITH DIURETICS. III. CHLORTHALIDONE ALONE AND IN COMBINATION WITH SPIRONOLACTONE.
Topics: Bendroflumethiazide; Cardiomegaly; Chlorides; Chlorthalidone; Coronary Disease; Creatine; Creatinine | 1964 |
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA.
Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C | 1965 |
[The 10-minute consultation. Accidental finding: hyperkalemia. Caution with analgesics and bananas].
Topics: Aged; Analgesics; Angiotensin-Converting Enzyme Inhibitors; Biopsy; Coronary Disease; Diabetes Melli | 2005 |
Neointimal thickening after balloon denudation is enhanced by aldosterone and inhibited by spironolactone, and aldosterone antagonist.
Topics: Aldosterone; Angioplasty, Balloon; Animals; Aorta; Blood Pressure; Coronary Disease; Iliac Artery; R | 1995 |
Left ventricular dysfunction: causes, natural history, and hopes for reversal.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Coronary Disease; | 2000 |
Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries.
Topics: Aldosterone; Angioplasty, Balloon; Animals; Collagen; Constriction, Pathologic; Coronary Disease; Co | 2001 |
Effect of treatment of hypertension in the primary preventive trial, Göteborg, Sweden.
Topics: Adrenergic beta-Antagonists; Bethanidine; Cardiovascular Diseases; Cerebrovascular Disorders; Corona | 1979 |
[Disorder of the mineralocorticoid function of the adrenals in the acute period of myocardial infarct and the ways for its correction].
Topics: Acute Disease; Adrenal Gland Diseases; Adult; Aged; Aldosterone; Chronic Disease; Coronary Disease; | 1979 |
[Treatment of refractory chronic circulatory insufficiency].
Topics: Adult; Aged; Benzothiadiazines; Cardiac Glycosides; Cardiomyopathies; Chronic Disease; Coronary Dise | 1976 |
Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorthalidone; Coronary Disease; Cyclopenthiazide; Diuretics; Fema | 1985 |
Characteristics of hypertension in the black population.
Topics: Adult; Angiotensin II; Animals; Black or African American; Cardiomegaly; Cerebrovascular Disorders; | 1974 |
Heart failure and cardiac arrhythmias.
Topics: Arrhythmia, Sinus; Arrhythmias, Cardiac; Coronary Disease; Digoxin; Diuretics; Electroconvulsive The | 1974 |
[Alterations in water-salt metabolism under the influence of diuretics in cardiac insufficiency].
Topics: Adult; Aged; Arteriosclerosis; Coronary Disease; Ethacrynic Acid; Female; Heart Failure; Humans; Mal | 1973 |
[Changes in water-salt metabolism in cardiac insufficiency under the influence of diuretic preparations].
Topics: Adult; Aged; Arteriosclerosis; Body Fluids; Chronic Disease; Coronary Disease; Diet Therapy; Ethacry | 1973 |
[Distribution of fluid between the cells and the extracellular media and mineralocorticoid function of the adrenal glands in cardiac insufficiency].
Topics: Adrenal Glands; Adult; Aldosterone; Antipyrine; Body Fluids; Chromatography, Paper; Coronary Disease | 1969 |
The role of catecholamines in circulatory regulation on the chronic congestive heart failure. Clinical study of the urinary catecholamine excretion in the patients with chronic congestive heart failure.
Topics: Adolescent; Adult; Aged; Blood Pressure; Cardiomyopathies; Catecholamines; Coronary Disease; Digital | 1968 |