spironolactone has been researched along with Coma in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirschl, MM | 1 |
| Seidler, D | 1 |
| Laggner, AN | 1 |
| Kokenge, F | 1 |
| Liedtke, R | 1 |
| Zepf, S | 1 |
| Bodin, F | 1 |
| Liguory, C | 1 |
| Capelle, P | 1 |
| Conte, M | 1 |
| Greenblatt, DJ | 1 |
| Koch-Weser, J | 1 |
4 other studies available for spironolactone and Coma
| Article | Year |
|---|---|
Spironolactone-associated hyponatremic coma.
Topics: Aged; Aged, 80 and over; Coma; Female; Humans; Hyponatremia; Spironolactone | 1994 |
[A contribution on diagnostic and therapy of myxoedema coma (author's transl)].
Topics: Aged; Coma; Female; Humans; Hyperaldosteronism; Myxedema; Remission, Spontaneous; Spironolactone; Tr | 1975 |
[Disorders of water-electrolyte metabolism associated with decompensated cirrhosis. The danger of various therapeutic drugs].
Topics: Acute Kidney Injury; Adult; Aged; Ascites; Blood Transfusion; Blood Urea Nitrogen; Blood Volume Dete | 1968 |
Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program.
Topics: Adult; Aged; Blood Urea Nitrogen; Coma; Dehydration; Diarrhea; Female; Gynecomastia; Headache; Heart | 1973 |