spironolactone has been researched along with Colitis in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, therapeutic role of the antibacterial drugs rifampicin and ciprofloxacine were investigated in comparison to spironolactone, an enzyme inducer, in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis of the rats." | 7.79 | A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats. ( Celikel, C; Cetinel, S; Dulger, GA; Imeryuz, N; Kabasakal, L; Kan, B; Orun, O; Toklu, HZ; Yuksel, M, 2013) |
| "Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality." | 5.38 | Spironolactone and colitis: increased mortality in rodents and in humans. ( Gillespie, BW; Govani, SM; Higgins, PD; Johnson, LA; Joyce, JC; Waljee, AK, 2012) |
| " In the present study, therapeutic role of the antibacterial drugs rifampicin and ciprofloxacine were investigated in comparison to spironolactone, an enzyme inducer, in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis of the rats." | 3.79 | A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats. ( Celikel, C; Cetinel, S; Dulger, GA; Imeryuz, N; Kabasakal, L; Kan, B; Orun, O; Toklu, HZ; Yuksel, M, 2013) |
| "Spironolactone is an antifibrotic medication commonly used in heart failure to reduce mortality." | 1.38 | Spironolactone and colitis: increased mortality in rodents and in humans. ( Gillespie, BW; Govani, SM; Higgins, PD; Johnson, LA; Joyce, JC; Waljee, AK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toklu, HZ | 1 |
| Kabasakal, L | 1 |
| Imeryuz, N | 1 |
| Kan, B | 1 |
| Celikel, C | 1 |
| Cetinel, S | 1 |
| Orun, O | 1 |
| Yuksel, M | 1 |
| Dulger, GA | 1 |
| Johnson, LA | 1 |
| Govani, SM | 1 |
| Joyce, JC | 1 |
| Waljee, AK | 1 |
| Gillespie, BW | 1 |
| Higgins, PD | 1 |
| Edmonds, CJ | 1 |
1 review available for spironolactone and Colitis
| Article | Year |
|---|---|
Electrical potential difference of colonic mucosa.
Topics: Aldosterone; Biological Transport, Active; Carbenoxolone; Colitis; Colon; Dinitrophenols; Electrodes | 1975 |
2 other studies available for spironolactone and Colitis
| Article | Year |
|---|---|
A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ciprofloxac | 2013 |
Spironolactone and colitis: increased mortality in rodents and in humans.
Topics: Animals; Clostridioides difficile; Clostridium Infections; Colitis; Crohn Disease; Female; Fibrosis; | 2012 |