Page last updated: 2024-11-07

spironolactone and Cicatrization

spironolactone has been researched along with Cicatrization in 4 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Cicatrization: The formation of fibrous tissue in the place of normal tissue during the process of WOUND HEALING. It includes scar tissue formation occurring in healing internal organs as well as in the skin after surface injuries.

Research Excerpts

ExcerptRelevanceReference
" Because aldosterone production in the heart increases after myocardial infarction (MI), we investigated the effect of chronic administration of spironolactone, an aldosterone receptor antagonist, in rats after MI compared with the effects produced by losartan and hydralazine."7.72Spironolactone prevents cardiac collagen proliferation after myocardial infarction in rats. ( de Resende, MM; Gomes, Mda G; Leite, CM; Milanez, Mda C; Mill, JG, 2003)
" Because aldosterone production in the heart increases after myocardial infarction (MI), we investigated the effect of chronic administration of spironolactone, an aldosterone receptor antagonist, in rats after MI compared with the effects produced by losartan and hydralazine."3.72Spironolactone prevents cardiac collagen proliferation after myocardial infarction in rats. ( de Resende, MM; Gomes, Mda G; Leite, CM; Milanez, Mda C; Mill, JG, 2003)
"Current guidelines for the treatment of acne are based largely on expert consensus and advocate a combination of topical agents in mild to moderate cases and reserve the use of systemic therapies for moderate to severe or refractory cases of acne."2.55Modern management of acne. ( Cooper, AJ; Harris, VR, 2017)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Berg, J1
Jablonowski, R1
Mohammad, M1
Solem, K1
Borgquist, R1
Ostenfeld, E1
Arheden, H1
Carlsson, M1
Cooper, AJ1
Harris, VR1
Mitts, TF1
Bunda, S1
Wang, Y1
Hinek, A1
Mill, JG1
Milanez, Mda C1
de Resende, MM1
Gomes, Mda G1
Leite, CM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Vitamin D and Its Topical Analogues: A Possible Role in the Pathogenesis and Treatment of Acne Vulgaris[NCT03866447]Phase 480 participants (Anticipated)Interventional2019-10-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for spironolactone and Cicatrization

ArticleYear
Modern management of acne.
    The Medical journal of Australia, 2017, Jan-16, Volume: 206, Issue:1

    Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Androgen Antagonists; Anti-Bacterial A

2017

Other Studies

3 other studies available for spironolactone and Cicatrization

ArticleYear
Ventricular longitudinal shortening is an independent predictor of death in heart failure patients with reduced ejection fraction.
    Scientific reports, 2021, 10-13, Volume: 11, Issue:1

    Topics: Aged; Aspirin; Body Mass Index; Cicatrix; Diuretics; Female; Fibrosis; Follow-Up Studies; Heart Fail

2021
Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin.
    The Journal of investigative dermatology, 2010, Volume: 130, Issue:10

    Topics: Adult; Aldosterone; Biopsy; Cells, Cultured; Cicatrix; Collagen Type I; Elasticity; Elastin; Epleren

2010
Spironolactone prevents cardiac collagen proliferation after myocardial infarction in rats.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:10

    Topics: Animals; Cicatrix; Collagen; Hydralazine; Losartan; Male; Myocardial Infarction; Myocardium; Organ S

2003