spironolactone has been researched along with Chemical and Drug Induced Liver Injury in 24 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Treatment with spironolactone, pregnenolone-16_-carbonitrile or triamcinolone reduced only slightly SGPT and triglycerides, but restored the reduced resistance to drugs, and the impairment of the liver drug metabolism in vitro." | 1.28 | Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents. ( Kourounakis, PN; Rekka, E, 1991) |
| " Dose-related increases in thyroid-stimulating hormone (TSH) levels were observed in treated animals of both sexes during the dosing period and the changes were statistically significant and correlated with an increased thyroid weight in females at 13 weeks." | 1.27 | The pathologic response of the liver and thyroid of the rat to potassium prorenoate (SC-23992). ( Lumb, GD; Rust, JH, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (58.33) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| CASCIO, G | 1 |
| PALAZZOADRIANO, M | 1 |
| Shuck, J | 1 |
| Shen, S | 1 |
| Owensby, L | 1 |
| Leftik, M | 1 |
| Cucinell, S | 1 |
| Renkes, P | 1 |
| Gaucher, P | 1 |
| Tréchot, P | 1 |
| Thai, KE | 1 |
| Sinclair, RD | 1 |
| Bjondahl, K | 1 |
| Bossone, CM | 1 |
| Hecht, Y | 1 |
| Rigaud, D | 1 |
| Celerier, M | 1 |
| Leclerc, JP | 1 |
| Ferrier, JP | 1 |
| Abshagen, U | 1 |
| Rennekamp, H | 1 |
| Luszpinski, G | 1 |
| Salas, M | 1 |
| Tuchweber, B | 1 |
| Kuntz, E | 1 |
| Kourounakis, PN | 1 |
| Rekka, E | 1 |
| Iacona, A | 1 |
| Rossetti, A | 1 |
| Filingeri, V | 1 |
| Orsini, D | 1 |
| Cesarini, A | 1 |
| Cervelli, V | 1 |
| Adorno, D | 1 |
| Casciani, CU | 1 |
| Lumb, GD | 1 |
| Rust, JH | 1 |
| Carlson, GP | 1 |
| Fuller, GC | 1 |
| Fausto, N | 1 |
| Ilinich, VK | 1 |
| Plastun, FF | 1 |
| Lazar, G | 1 |
| Szabo, S | 1 |
| Husztik, E | 1 |
| Mansurova, ID | 1 |
| Chernyshov, VG | 1 |
| Stosman, RZ | 1 |
| Taft, LI | 1 |
2 reviews available for spironolactone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Treatment of acute hepatic insufficiency (a survey of the literature)].
Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr | 1972 |
22 other studies available for spironolactone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
[PHARMACOLOGICAL ACTIONS OF 2 HETEROCYCLIC GLYOXYLIC ALDEHYDES WITH NOTABLE DIURETIC ACTIVITY].
Topics: Aldehydes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorothiazide; C | 1964 |
Spironolactone hepatitis in primary hyperaldosteronism.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hyperaldosteronism; Liver; Middle Aged; Spir | 1981 |
Spironolactone and hepatic toxicity.
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Male; Spironolactone | 1995 |
Spironolactone-induced hepatitis.
Topics: Alopecia; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Middle Aged; | 2001 |
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver | 1978 |
The liver: a pharmacologic perspective.
Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec | 1977 |
[Cholestatic hepatitis due to ajmaline. Lymphatic congestion of the liver. Recovery after spironolactone].
Topics: Ajmaline; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle Aged; Spironol | 1978 |
Disposition kinetics of spironolactone in hepatic failure after single doses and prolonged treatment.
Topics: Adult; Chemical and Drug Induced Liver Injury; Half-Life; Humans; Kinetics; Liver Cirrhosis; Liver D | 1977 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estra | 1976 |
[Edematous hepatitis: a special form of acute virus hepatitis with secondary aldosteronism (author's transl)].
Topics: Adult; Aldosterone; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Edema; Female; | 1975 |
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
Topics: Alanine Transaminase; Animals; Arthritis, Experimental; Chemical and Drug Induced Liver Injury; Fema | 1991 |
Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Enalapril; | 1991 |
The pathologic response of the liver and thyroid of the rat to potassium prorenoate (SC-23992).
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Female; Lethal Dose 50; Liver; Male; Microsom | 1985 |
Effects of spironolactone on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisonin | 1974 |
The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Chemical and Drug Induced Liver Injury; Ethylestren | 1972 |
[Effect of CC1-4 and aldactone on the activity of acid hydrolases and deamination enzymes in rat liver].
Topics: Acid Phosphatase; Aminohydrolases; Ammonia-Lyases; Animals; Carbon Tetrachloride Poisoning; Chemical | 1973 |
Methotrexate induced hepatitis in childhood leukemia.
Topics: Aminopterin; Biopsy; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans | 1965 |