spironolactone has been researched along with Cell Transformation, Neoplastic in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primary aldosteronism (PA, also Conn syndrome) is a benign disease in majority of cases." | 1.40 | Predictors of malignancy in primary aldosteronism. ( Agha, A; Haneya, A; Hornung, M; Iesalnieks, I; Jung, EM; Schlitt, HJ; Schreyer, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agha, A | 1 |
| Hornung, M | 1 |
| Iesalnieks, I | 1 |
| Schreyer, A | 1 |
| Jung, EM | 1 |
| Haneya, A | 1 |
| Schlitt, HJ | 1 |
| Queisser, N | 1 |
| Amann, K | 1 |
| Hey, V | 1 |
| Habib, SL | 1 |
| Schupp, N | 1 |
| Loube, SD | 1 |
| Quirk, RA | 1 |
3 other studies available for spironolactone and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Predictors of malignancy in primary aldosteronism.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Aged; Aldosterone; Cell Transformation, Neoplastic; Female; | 2014 |
Blood pressure has only minor influence on aldosterone-induced oxidative stress and DNA damage in vivo.
Topics: Aldosterone; Animals; Apoptosis; Blood Pressure; Cell Transformation, Neoplastic; Cells, Cultured; C | 2013 |
Letter: Breast cancer associated with administration of spironolactone.
Topics: Aged; Breast; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans; Middle Aged; Recept | 1975 |