spironolactone has been researched along with Carditis in 13 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate whether eplerenone, a selective aldosterone receptor antagonist, has anti-inflammatory effects on viral myocarditis." | 7.75 | Anti-inflammatory effects of eplerenone on viral myocarditis. ( Hu, D; Liu, W; Matsumori, A; Shimada, M; Xiao, J, 2009) |
| " We studied the effects of eplerenone, a novel aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy after autoimmune myocarditis." | 7.73 | Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy. ( Aizawa, Y; Kodama, M; Ma, M; Tachikawa, H; Takahashi, T; Wahed, MI; Watanabe, K; Yamaguchi, K, 2005) |
| "To identify the effects of diuretic agents on adverse cardiac remodeling in CHF, this study was carried out, where we have compared the effects of torasemide and spironolactone in a rat model of dilated cardiomyopathy induced by porcine cardiac myosin-mediated experimental autoimmune myocarditis." | 3.85 | Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy. ( Arumugam, S; Harima, M; Karuppagounder, V; Nakamura, M; Sone, H; Sreedhar, R; Suzuki, H; Watanabe, K, 2017) |
| " The aim of this study was to investigate whether eplerenone, a selective aldosterone receptor antagonist, has anti-inflammatory effects on viral myocarditis." | 3.75 | Anti-inflammatory effects of eplerenone on viral myocarditis. ( Hu, D; Liu, W; Matsumori, A; Shimada, M; Xiao, J, 2009) |
| " We studied the effects of eplerenone, a novel aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy after autoimmune myocarditis." | 3.73 | Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy. ( Aizawa, Y; Kodama, M; Ma, M; Tachikawa, H; Takahashi, T; Wahed, MI; Watanabe, K; Yamaguchi, K, 2005) |
| "In experimental hyperaldosteronism, the increase in Gal-3 expression was associated with cardiac inflammation and fibrosis, alterations that were prevented by Gal-3 blockade independently of blood pressure levels." | 1.42 | Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertension. ( Cachofeiro, V; Calvier, L; Fernández-Celis, A; Jaisser, F; Jurado-López, R; López-Andrés, N; Martínez-Martínez, E; Rossignol, P; Rossoni, LV; Rousseau, E; Zannad, F, 2015) |
| "A case of systemic lupus erythematosus (SLE) associated with fever, heart failure, and left ventricular (LV) aneurysm is reported." | 1.29 | Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus. ( Caldarulo, M; Frustaci, A; Gentiloni, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Lu, X | 1 |
| Wang, X | 1 |
| Qiu, Q | 1 |
| Zhu, P | 1 |
| Ma, L | 1 |
| Ma, X | 1 |
| Herrmann, J | 1 |
| Lin, X | 1 |
| Wang, W | 1 |
| Xu, X | 1 |
| Arumugam, S | 1 |
| Sreedhar, R | 1 |
| Karuppagounder, V | 1 |
| Harima, M | 1 |
| Nakamura, M | 1 |
| Suzuki, H | 1 |
| Sone, H | 1 |
| Watanabe, K | 2 |
| Yasuoka, S | 1 |
| Kai, H | 1 |
| Kajimoto, H | 1 |
| Kudo, H | 1 |
| Takayama, N | 1 |
| Anegawa, T | 1 |
| Koga, M | 1 |
| Miyamoto, T | 1 |
| Mifune, H | 1 |
| Kage, M | 1 |
| Hirooka, Y | 1 |
| Imaizumi, T | 1 |
| Mody, KP | 1 |
| Lyons, JJ | 1 |
| Jorde, UP | 1 |
| Uriel, N | 1 |
| Martínez-Martínez, E | 1 |
| Calvier, L | 1 |
| Fernández-Celis, A | 1 |
| Rousseau, E | 1 |
| Jurado-López, R | 1 |
| Rossoni, LV | 1 |
| Jaisser, F | 1 |
| Zannad, F | 1 |
| Rossignol, P | 1 |
| Cachofeiro, V | 1 |
| López-Andrés, N | 1 |
| Xiao, J | 1 |
| Shimada, M | 1 |
| Liu, W | 1 |
| Hu, D | 1 |
| Matsumori, A | 1 |
| Dabrowski, R | 1 |
| Pedzich-Placha, E | 1 |
| SANDERS, LL | 1 |
| MELBY, JC | 1 |
| Wahed, MI | 1 |
| Ma, M | 1 |
| Yamaguchi, K | 1 |
| Takahashi, T | 1 |
| Tachikawa, H | 1 |
| Kodama, M | 1 |
| Aizawa, Y | 1 |
| Kuster, GM | 1 |
| Kotlyar, E | 1 |
| Rude, MK | 1 |
| Siwik, DA | 1 |
| Liao, R | 1 |
| Colucci, WS | 1 |
| Sam, F | 1 |
| Neves, MF | 1 |
| Amiri, F | 1 |
| Virdis, A | 1 |
| Diep, QN | 1 |
| Schiffrin, EL | 1 |
| Fraccarollo, D | 1 |
| Galuppo, P | 1 |
| Schraut, S | 1 |
| Kneitz, S | 1 |
| van Rooijen, N | 1 |
| Ertl, G | 1 |
| Bauersachs, J | 1 |
| Frustaci, A | 1 |
| Gentiloni, N | 1 |
| Caldarulo, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Spironolactone in the Prevention of Anthracycline-induced Cardiotoxicity: a Randomized Clinical Trial (SPIROTOX Trial)[NCT06005259] | Phase 4 | 264 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for spironolactone and Carditis
| Article | Year |
|---|---|
Topics: Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 7; Cardiotoxicity; Doxorubicin; | 2021 |
Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy.
Topics: Animals; Autoimmunity; Biomarkers; Cardiac Myosins; Cardiomyopathy, Dilated; Disease Models, Animal; | 2017 |
Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats.
Topics: Active Transport, Cell Nucleus; Aldosterone; Animals; Blood Pressure; Cardiomegaly; Cell Nucleus; Ep | 2013 |
A cold taken to heart.
Topics: Adenoviridae Infections; Adult; Biopsy; Cardiovascular Agents; Combined Modality Therapy; Defibrilla | 2015 |
Galectin-3 blockade inhibits cardiac inflammation and fibrosis in experimental hyperaldosteronism and hypertension.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Fibroblasts; Fibrosis; Galectin 3; Humans; Hyperal | 2015 |
Anti-inflammatory effects of eplerenone on viral myocarditis.
Topics: Animals; Cardiovirus Infections; Disease Models, Animal; DNA, Viral; Encephalomyocarditis virus; Epl | 2009 |
[Improvement of left ventricular function during combined carvedilol, ramipril and spironolactone therapy after myocarditis in patient treated earlier by chemotherapy due to Hodgkin's lymphoma - 3-years follow-up].
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Carbazoles; Carvedilol | 2010 |
ALDOSTERONE AND THE EDEMA OF CONGESTIVE HEART FAILURE.
Topics: Aldosterone; Chromatography; Diuretics; Edema; Geriatrics; Heart Diseases; Heart Failure; Hypertensi | 1964 |
Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy.
Topics: Animals; Autoimmune Diseases; Cardiomyopathy, Dilated; Collagen Type III; Dose-Response Relationship | 2005 |
Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload.
Topics: Animals; Aorta; Apoptosis; Blood Pressure; Cell Size; Chronic Disease; Constriction, Pathologic; Dru | 2005 |
Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy.
Topics: Aldosterone; Angiotensin II; Animals; Aorta; Collagen; Ectodysplasins; Fibrosis; Heart; Hypertension | 2005 |
Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.
Topics: Aldosterone; Animals; Clodronic Acid; Collagen; Cytokines; Eplerenone; Factor XIIIa; Heart Failure; | 2008 |
Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Cardiac Output, Low; Diuretics; Endocarditis; Fever; | 1996 |