spironolactone has been researched along with Cardiac Output, Low in 19 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of spironolactone with an ACE inhibitor for patients with heart failure may cause severe hyperkalemia." | 3.73 | [Successful resuscitation of a patient with hyperkalemic cardiac arrest by emergency hemodiafiltration]. ( Gütlich, D; Hochscherf, M; Hopf, HB, 2005) |
| "However, incidence of postoperative low cardiac output state (p < 0." | 1.48 | Preoperative aldosterone receptor blockade and outcomes of cardiac surgery in patients with chronic kidney disease . ( Bitran, D; Fink, D; Merin, O; Shavit, L; Silberman, S; Tauber, R, 2018) |
| " Daily dosage of ACE inhibitors and particularly of beta-blockers was on average below the recommended target dose." | 1.32 | The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. ( Aguilar, JC; Cleland, J; Cohen-Solal, A; Dietz, R; Eastaugh, J; Follath, F; Freemantle, N; Gavazzi, A; Hobbs, R; Komajda, M; Korewicki, J; Madeira, HC; Mason, J; Moiseyev, VS; Preda, I; Swedberg, K; Van Gilst, WH; Widimsky, J, 2003) |
| "A case of systemic lupus erythematosus (SLE) associated with fever, heart failure, and left ventricular (LV) aneurysm is reported." | 1.29 | Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus. ( Caldarulo, M; Frustaci, A; Gentiloni, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 17 (89.47) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shavit, L | 1 |
| Silberman, S | 1 |
| Tauber, R | 1 |
| Merin, O | 1 |
| Bitran, D | 1 |
| Fink, D | 1 |
| Komajda, M | 1 |
| Follath, F | 1 |
| Swedberg, K | 1 |
| Cleland, J | 1 |
| Aguilar, JC | 1 |
| Cohen-Solal, A | 1 |
| Dietz, R | 1 |
| Gavazzi, A | 1 |
| Van Gilst, WH | 1 |
| Hobbs, R | 1 |
| Korewicki, J | 1 |
| Madeira, HC | 1 |
| Moiseyev, VS | 1 |
| Preda, I | 1 |
| Widimsky, J | 1 |
| Freemantle, N | 1 |
| Eastaugh, J | 1 |
| Mason, J | 1 |
| Funder, JW | 2 |
| Perkerson, KA | 1 |
| Coleman, CI | 1 |
| White, CM | 1 |
| Kochsiek, K | 1 |
| Heinzl, S | 1 |
| Gütlich, D | 1 |
| Hochscherf, M | 1 |
| Hopf, HB | 1 |
| Nagata, K | 1 |
| Obata, K | 1 |
| Xu, J | 1 |
| Ichihara, S | 1 |
| Noda, A | 1 |
| Kimata, H | 1 |
| Kato, T | 1 |
| Izawa, H | 1 |
| Murohara, T | 1 |
| Yokota, M | 1 |
| Kobayashi, N | 2 |
| Yoshida, K | 1 |
| Nakano, S | 1 |
| Ohno, T | 1 |
| Honda, T | 1 |
| Tsubokou, Y | 1 |
| Matsuoka, H | 2 |
| Nishi, I | 1 |
| Kawano, S | 1 |
| Misaki, M | 1 |
| Hoshi, T | 1 |
| Masumi, T | 1 |
| Iida, K | 1 |
| Watanabe, S | 1 |
| Yamaguchi, I | 1 |
| Pitt, B | 1 |
| Ferrari, R | 1 |
| Gheorghiade, M | 1 |
| van Veldhuisen, DJ | 2 |
| Krum, H | 1 |
| McMurray, J | 1 |
| Lopez-Sendon, J | 1 |
| van der Horst, IC | 1 |
| Voors, AA | 1 |
| Onozato, ML | 1 |
| Tojo, A | 1 |
| Goto, A | 1 |
| Fujita, T | 1 |
| Gislason, GH | 1 |
| Rasmussen, JN | 1 |
| Abildstrom, SZ | 1 |
| Schramm, TK | 1 |
| Hansen, ML | 1 |
| Buch, P | 1 |
| Sørensen, R | 1 |
| Folke, F | 1 |
| Gadsbøll, N | 1 |
| Rasmussen, S | 1 |
| Køber, L | 1 |
| Madsen, M | 1 |
| Torp-Pedersen, C | 1 |
| Frustaci, A | 1 |
| Gentiloni, N | 1 |
| Caldarulo, M | 1 |
| Zannad, F | 1 |
| Massin, M | 1 |
| Coremans, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE)[NCT05204238] | 998 participants (Actual) | Observational | 2020-09-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for spironolactone and Cardiac Output, Low
| Article | Year |
|---|---|
Aldosterone resurgens--letter from EPHESUS.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiovascular Diseases; Eplerenone; Humans; Inflammation | 2003 |
Aldosterone receptor antagonists in the treatment of heart failure.
Topics: Aged; Cardiac Output, Low; Clinical Trials as Topic; Eplerenone; Humans; Male; Mineralocorticoid Rec | 2003 |
Aldosterone blockade in post-acute myocardial infarction heart failure.
Topics: Algorithms; Cardiac Output, Low; Eplerenone; Humans; Hyperkalemia; Hypotension; Mineralocorticoid Re | 2006 |
Spironolactone in severe heart failure: enhances efficacy of diuretic + ACE inhibitor combinations.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cardiac Output, Low; Clinical Trials as Topic; Contraindic | 2000 |
[Chronic heart failure in children: recent contributions of physiopathology and therapeutic implications].
Topics: Adrenergic beta-Antagonists; Age Factors; Angiotensin-Converting Enzyme Inhibitors; Cardiac Output, | 2001 |
1 trial available for spironolactone and Cardiac Output, Low
| Article | Year |
|---|---|
[Angiotensin receptor blockers in heart failure. CHARM Study].
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme | 2004 |
13 other studies available for spironolactone and Cardiac Output, Low
| Article | Year |
|---|---|
Preoperative aldosterone receptor blockade and outcomes of cardiac surgery in patients with chronic kidney disease
.
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Cardiac Output, Low; Cardiac Surgical Procedures; Fema | 2018 |
The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Aspirin; C | 2003 |
[Aldosterone and aldosterone antagonists. Eplerenone in cardiac insufficiency after myocardial infarction].
Topics: Aldosterone; Cardiac Output, Low; Eplerenone; Humans; Mineralocorticoid Receptor Antagonists; Myocar | 2005 |
[Successful resuscitation of a patient with hyperkalemic cardiac arrest by emergency hemodiafiltration].
Topics: Angiotensin-Converting Enzyme Inhibitors; Cardiac Output, Low; Cardiopulmonary Resuscitation; Diabet | 2005 |
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiomegaly; Cardiotonic Agents; Coronary Vessels; Corti | 2006 |
Mineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.
Topics: Aldosterone; Animals; Cardiac Output, Low; Cardiomegaly; Cardiotonic Agents; Corticosterone; Epleren | 2006 |
Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.
Topics: Animals; Cardiac Output, Low; Cardiotonic Agents; Drug Interactions; Echocardiography; Elasticity; E | 2006 |
Addition of spironolactone to an angiotensin-converting enzyme inhibitor decreases lung congestion and edema in Dahl hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiac Output, Low; Drug Therapy, Combination; H | 2006 |
Treatment of heart failure with ACE inhibitors and beta-blockers: what is next? Aldosterone receptor antagonists?
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cardiac Output, Low; Chronic | 2007 |
Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney.
Topics: Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiac Output, Low; | 2007 |
Persistent use of evidence-based pharmacotherapy in heart failure is associated with improved outcomes.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 2 Receptor Blockers; Angiotensin-Converting | 2007 |
Acute myocarditis and left ventricular aneurysm as presentations of systemic lupus erythematosus.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Cardiac Output, Low; Diuretics; Endocarditis; Fever; | 1996 |
[Anti-aldosterone: the evidence of the RALES study].
Topics: Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Cardiac Output, Low; Diuretics; Endomyocardial | 2000 |