spironolactone has been researched along with Calcinosis in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Calcinosis: Pathologic deposition of calcium salts in tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone (SP) has been widely used as a diuretic in clinical practice." | 1.62 | Spironolactone Ameliorates Senescence and Calcification by Modulating Autophagy in Rat Tendon-Derived Stem Cells via the NF- ( Chen, M; He, Y; Lin, C; Ma, C; Ma, D; Moqbel, SAA; Wu, L; Xu, K; Zhou, X, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, K | 1 |
| Lin, C | 1 |
| Ma, D | 1 |
| Chen, M | 1 |
| Zhou, X | 1 |
| He, Y | 1 |
| Moqbel, SAA | 1 |
| Ma, C | 1 |
| Wu, L | 1 |
| Nitta, K | 1 |
| Akiba, T | 1 |
| Nihei, H | 1 |
| Greathouse, DJ | 1 |
| McDermott, MT | 1 |
| Kidd, GS | 1 |
| Hofeldt, FD | 1 |
| Gardell, C | 1 |
| Tuchweber, B | 1 |
| Hatakeyama, S | 1 |
| Kovacs, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Spironolactone on the Progression of Coronary Calcification in Peritoneal Dialysis Patients[NCT03314493] | Phase 3 | 33 participants (Actual) | Interventional | 2014-11-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for spironolactone and Calcinosis
| Article | Year |
|---|---|
Spironolactone Ameliorates Senescence and Calcification by Modulating Autophagy in Rat Tendon-Derived Stem Cells via the NF-
Topics: Achilles Tendon; Animals; Autophagy; Calcinosis; Mitogen-Activated Protein Kinases; NF-kappa B; Rats | 2021 |
Aldosterone blockade and vascular calcification in hemodialysis patients.
Topics: Administration, Oral; Animals; Calcinosis; Eplerenone; Humans; Kidney Failure, Chronic; Male; Middle | 2003 |
Pure primary hyperaldosteronism due to adrenal cortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Calcinosis; Carcinoma; Female; Humans; Hyperaldosteronism; Hypertension; H | 1984 |
[Steroids and nephrectomy cardiopathy].
Topics: Animals; Calcinosis; Cardiovascular Diseases; Desoxycorticosterone; Estradiol; Ethylestrenol; Heart | 1970 |