spironolactone has been researched along with Bulbo-Spinal Atrophy, X-Linked in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Bulbo-Spinal Atrophy, X-Linked: An X-linked recessive form of spinal muscular atrophy. It is due to a mutation of the gene encoding the ANDROGEN RECEPTOR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinal and bulbar muscular atrophy is caused by polyglutamine expansion in the androgen receptor." | 1.43 | Sexual Reassignment Fails to Prevent Kennedy's Disease. ( Badders, NM; Bakar, D; Bott, LC; Burke, A; Fischbeck, KH; Grunseich, C; Harmison, GG; Joe, GO; Kokkinis, A; Lanman, TA; Schindler, AB; Shrader, JA; Taylor, JP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lanman, TA | 1 |
| Bakar, D | 1 |
| Badders, NM | 1 |
| Burke, A | 1 |
| Kokkinis, A | 1 |
| Shrader, JA | 1 |
| Joe, GO | 1 |
| Schindler, AB | 1 |
| Bott, LC | 1 |
| Harmison, GG | 1 |
| Taylor, JP | 1 |
| Fischbeck, KH | 1 |
| Grunseich, C | 1 |
1 other study available for spironolactone and Bulbo-Spinal Atrophy, X-Linked
| Article | Year |
|---|---|
Sexual Reassignment Fails to Prevent Kennedy's Disease.
Topics: Androgen Antagonists; Animals; Bulbo-Spinal Atrophy, X-Linked; Disease Models, Animal; Drosophila; F | 2016 |