spironolactone has been researched along with Bronchopulmonary Dysplasia in 8 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Bronchopulmonary Dysplasia: A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that spironolactone-hydrochlorothiazide (Aldactazide) will improve urine output and lung function in infants with bronchopulmonary dysplasia, we studied 21 hospitalized, spontaneously breathing, oxygen-dependent infants with chronic bronchopulmonary dysplasia." | 9.06 | Effect of spironolactone-hydrochlorothiazide on lung function in infants with chronic bronchopulmonary dysplasia. ( Blalock, WA; DonLevy, S; Engelhardt, B; Hazinski, TA; Rush, M, 1989) |
| "We studied the effects of orally administered theophylline and diuretics (chlorothiazide and spironolactone) on pulmonary mechanics in 16 infants with bronchopulmonary dysplasia." | 9.06 | Oral theophylline and diuretics improve pulmonary mechanics in infants with bronchopulmonary dysplasia. ( Durand, DJ; Kao, LC; Nickerson, BG; Phillips, BL, 1987) |
| "We randomly selected 43 stable patients with oxygen-dependent bronchopulmonary dysplasia to receive either orally administered spironolactone and chlorothiazide or placebo." | 5.07 | Randomized trial of long-term diuretic therapy for infants with oxygen-dependent bronchopulmonary dysplasia. ( Birch, M; Durand, DJ; Kao, LC; McCrea, RC; Nickerson, BG; Powers, RJ, 1994) |
| "The effects of continuous therapy with hydrochlorothiazide and spironolactone on pulmonary function in 34 premature infants with severe bronchopulmonary dysplasia were assessed in a randomized double-blind controlled trial." | 5.06 | Randomized, double-blind, controlled trial of long-term diuretic therapy for bronchopulmonary dysplasia. ( Albersheim, SG; Rotschild, A; Sharma, AK; Sheps, SB; Smyth, JA; Solimano, AJ; Wood, BJ, 1989) |
| "We studied the effects of orally administered theophylline and diuretics (chlorothiazide and spironolactone) on pulmonary mechanics in 16 infants with bronchopulmonary dysplasia." | 5.06 | Oral theophylline and diuretics improve pulmonary mechanics in infants with bronchopulmonary dysplasia. ( Durand, DJ; Kao, LC; Nickerson, BG; Phillips, BL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Laughon, MM | 1 |
| Chantala, K | 1 |
| Aliaga, S | 1 |
| Herring, AH | 1 |
| Hornik, CP | 1 |
| Hughes, R | 1 |
| Clark, RH | 1 |
| Smith, PB | 1 |
| Segar, JL | 1 |
| Kao, LC | 3 |
| Warburton, D | 1 |
| Cheng, MH | 1 |
| Cedeño, C | 1 |
| Platzker, AC | 1 |
| Keens, TG | 1 |
| Durand, DJ | 2 |
| McCrea, RC | 1 |
| Birch, M | 1 |
| Powers, RJ | 1 |
| Nickerson, BG | 2 |
| Albersheim, SG | 1 |
| Solimano, AJ | 1 |
| Sharma, AK | 1 |
| Smyth, JA | 1 |
| Rotschild, A | 1 |
| Wood, BJ | 1 |
| Sheps, SB | 1 |
| Engelhardt, B | 1 |
| Blalock, WA | 1 |
| DonLevy, S | 1 |
| Rush, M | 1 |
| Hazinski, TA | 1 |
| Escobedo, MB | 1 |
| Gonzalez, A | 1 |
| Phillips, BL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease[NCT01721655] | Phase 2/Phase 3 | 40 participants (Anticipated) | Interventional | 2012-10-31 | Recruiting | ||
| A Retrospective Chart Review Evaluating the Impact of Steroid, Diuretic, and Fluid Use Practice Trends in Extreme Premature Infants at Risk for Bronchopulmonary Dysplasia (BPD) at a Single Center Neonatal Intensive Care Unit[NCT04971694] | 175 participants (Anticipated) | Observational | 2021-09-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spironolactone and Bronchopulmonary Dysplasia
| Article | Year |
|---|---|
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
5 trials available for spironolactone and Bronchopulmonary Dysplasia
| Article | Year |
|---|---|
Effect of oral diuretics on pulmonary mechanics in infants with chronic bronchopulmonary dysplasia: results of a double-blind crossover sequential trial.
Topics: Administration, Oral; Airway Resistance; Body Weight; Bronchopulmonary Dysplasia; Chlorothiazide; Cl | 1984 |
Randomized trial of long-term diuretic therapy for infants with oxygen-dependent bronchopulmonary dysplasia.
Topics: Analysis of Variance; Bronchopulmonary Dysplasia; Chlorothiazide; Double-Blind Method; Drug Therapy, | 1994 |
Randomized, double-blind, controlled trial of long-term diuretic therapy for bronchopulmonary dysplasia.
Topics: Bronchopulmonary Dysplasia; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studie | 1989 |
Effect of spironolactone-hydrochlorothiazide on lung function in infants with chronic bronchopulmonary dysplasia.
Topics: Bronchopulmonary Dysplasia; Drug Combinations; Hemoglobins; Humans; Hydrochlorothiazide; Infant; Inf | 1989 |
Oral theophylline and diuretics improve pulmonary mechanics in infants with bronchopulmonary dysplasia.
Topics: Administration, Oral; Bronchopulmonary Dysplasia; Chlorothiazide; Clinical Trials as Topic; Double-B | 1987 |
2 other studies available for spironolactone and Bronchopulmonary Dysplasia
| Article | Year |
|---|---|
Diuretic exposure in premature infants from 1997 to 2011.
Topics: Acetazolamide; Amiloride; Bronchopulmonary Dysplasia; Chlorothiazide; Cohort Studies; Diazoxide; Diu | 2015 |
Bronchopulmonary dysplasia in the tiny infant.
Topics: Adrenal Cortex Hormones; Barotrauma; Bronchodilator Agents; Bronchopulmonary Dysplasia; Carbon Dioxi | 1986 |