spironolactone has been researched along with Brain Ischemia in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previous studies from our laboratory have shown that chronic treatment with spironolactone, a mineralocorticoid receptor (MR) antagonist, decreases ischemic cerebral infarct size and prevents remodeling of the middle cerebral artery (MCA) in male spontaneously hypertensive stroke-prone rats (SHRSP)." | 3.74 | Intact female stroke-prone hypertensive rats lack responsiveness to mineralocorticoid receptor antagonists. ( Burch, AE; Dorrance, AM; Ogbi, S; Pollock, DM; Rigsby, CS, 2007) |
| "Treatment with eplerenone at a dose of 1." | 1.34 | Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model. ( Gao, XY; Horiuchi, M; Ide, A; Iwai, M; Iwanami, J; Li, JM; Min, LJ; Mogi, M; Okamoto, S; Tsukuda, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frieler, RA | 1 |
| Ray, JJ | 1 |
| Meng, H | 1 |
| Ramnarayanan, SP | 1 |
| Usher, MG | 1 |
| Su, EJ | 1 |
| Berger, S | 1 |
| Pinsky, DJ | 1 |
| Lawrence, DA | 1 |
| Wang, MM | 1 |
| Mortensen, RM | 1 |
| Iwanami, J | 1 |
| Mogi, M | 1 |
| Okamoto, S | 1 |
| Gao, XY | 1 |
| Li, JM | 1 |
| Min, LJ | 1 |
| Ide, A | 1 |
| Tsukuda, K | 1 |
| Iwai, M | 1 |
| Horiuchi, M | 1 |
| Rigsby, CS | 1 |
| Burch, AE | 1 |
| Ogbi, S | 1 |
| Pollock, DM | 1 |
| Dorrance, AM | 1 |
| Ignelzi, RJ | 1 |
4 other studies available for spironolactone and Brain Ischemia
| Article | Year |
|---|---|
Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Eplerenone; Female; Gene Expression Profiling; Immu | 2012 |
Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model.
Topics: Animals; Blood Pressure; Brain Ischemia; Disease Models, Animal; Eplerenone; Infarction, Middle Cere | 2007 |
Intact female stroke-prone hypertensive rats lack responsiveness to mineralocorticoid receptor antagonists.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Eplerenone; Female; Male; Mineralocorticoid Receptor Ant | 2007 |
Effect of various drugs on ischemic glial nuclei.
Topics: Acetazolamide; Animals; Brain; Brain Ischemia; Cell Nucleus; Dexamethasone; Female; Furosemide; Hypo | 1979 |