spironolactone has been researched along with Brain Injuries in 11 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients who received spironolactone were significantly less likely to experience mild, moderate, or severe hypokalemia (8." | 9.14 | Spironolactone in preventing hypokalemia following traumatic brain injury. ( Abrishamkar, S; Shafiei, M, 2010) |
| " Patients who received spironolactone were significantly less likely to experience mild, moderate, or severe hypokalemia (8." | 5.14 | Spironolactone in preventing hypokalemia following traumatic brain injury. ( Abrishamkar, S; Shafiei, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Yu, Y | 1 |
| Qiao, J | 1 |
| Zhu, L | 1 |
| Xiao, Z | 1 |
| Abrishamkar, S | 1 |
| Shafiei, M | 2 |
| McCullers, DL | 2 |
| Sullivan, PG | 2 |
| Scheff, SW | 2 |
| Herman, JP | 2 |
| Oberbauer, R | 1 |
| Heppner, F | 1 |
| Auer, L | 1 |
| Haferkamp, G | 1 |
| Regli, F | 1 |
| Nisch, G | 1 |
| Baethmann, A | 2 |
| Lanksch, W | 1 |
| Schmiedek, P | 1 |
| Brendel, W | 1 |
| Koczorek, KR | 1 |
| Enzenbach, R | 1 |
| Mansuy, L | 1 |
| Fischer, G | 1 |
| Bret, P | 1 |
| Ravon, R | 1 |
1 review available for spironolactone and Brain Injuries
| Article | Year |
|---|---|
[Pathophysiology of traumatic brain edema. Findings and hypotheses].
Topics: Acid-Base Equilibrium; Aldosterone; Animals; Brain Edema; Brain Injuries; Humans; Mineralocorticoid | 1970 |
2 trials available for spironolactone and Brain Injuries
| Article | Year |
|---|---|
Spironolactone in preventing hypokalemia following traumatic brain injury.
Topics: Adult; Brain Injuries; Female; Humans; Hypokalemia; Male; Middle Aged; Spironolactone | 2010 |
[Therapy of traumatic brain edema with spironolactone (author's transl)].
Topics: Adolescent; Adult; Brain; Brain Edema; Brain Injuries; Clinical Trials as Topic; Double-Blind Method | 1979 |
8 other studies available for spironolactone and Brain Injuries
| Article | Year |
|---|---|
Mineralocorticoid receptor excessive activation involved in glucocorticoid-related brain injury.
Topics: Animals; Apoptosis; Atrophy; Blood Pressure; Brain Injuries; Dexamethasone; Fibrosis; Glucocorticoid | 2020 |
Traumatic brain injury regulates adrenocorticosteroid receptor mRNA levels in rat hippocampus.
Topics: Adrenocorticotropic Hormone; Animals; Brain Injuries; Corticosterone; Hippocampus; Hormone Antagonis | 2002 |
Mifepristone protects CA1 hippocampal neurons following traumatic brain injury in rat.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain Injuries; Cell Survival; Glucocorticoids; Hipp | 2002 |
[Modern pathophysiological aspects regarding the treatment of brain edema (author's transl)].
Topics: Aldosterone; Brain Abscess; Brain Edema; Brain Injuries; Brain Neoplasms; Cerebral Ventricles; Dexam | 1978 |
[Prevention of brain edema and dehydrating therapy in acute brain injury].
Topics: Brain; Brain Edema; Brain Injuries; Fructose; Glucose; Mannitol; Osmolar Concentration; Oxygen; Sorb | 1975 |
[Soludactone and neurosurgical recovery].
Topics: Adrenal Cortex Hormones; Blood Gas Analysis; Brain Diseases; Brain Edema; Brain Injuries; Brain Neop | 1974 |
Formation and treatment of cerebral edema.
Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Ac | 1974 |
[Cerebral edema and hyperaldosteronism].
Topics: Brain Edema; Brain Injuries; Humans; Hyperaldosteronism; Potassium; Sodium; Spironolactone | 1970 |