spironolactone has been researched along with Brain Edema in 26 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brain edema was measured on day 5 by MRI, histochemical staining of brain sections and tissue water content determination (n=7, each experiment)." | 1.43 | Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression. ( Aono, H; Choudhury, ME; Fujita, T; Islam, A; Mise, A; Miyanishi, K; Nishioka, R; Sugimoto, K; Takahashi, H; Takeda, H; Tanaka, J; Yano, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (96.15) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishioka, R | 1 |
| Sugimoto, K | 1 |
| Aono, H | 1 |
| Mise, A | 1 |
| Choudhury, ME | 1 |
| Miyanishi, K | 1 |
| Islam, A | 1 |
| Fujita, T | 1 |
| Takeda, H | 1 |
| Takahashi, H | 1 |
| Yano, H | 1 |
| Tanaka, J | 1 |
| Rosendahl, W | 1 |
| Naujoks, S | 1 |
| Hartmann, A | 2 |
| Guerrero Fernandez-Marcote, JA | 1 |
| Vara Thorbeck, R | 1 |
| Schütz, HJ | 1 |
| Alberti, E | 1 |
| Schreckenberger, F | 1 |
| Di Constanzo, J | 1 |
| Cano, N | 1 |
| Sarrat, P | 1 |
| Millet, Y | 1 |
| Gauthier, A | 1 |
| Guibert, F | 1 |
| Laporte, A | 1 |
| Bidabe, AM | 1 |
| Henry, P | 1 |
| Caille, JM | 1 |
| Oberbauer, R | 1 |
| Heppner, F | 1 |
| Auer, L | 1 |
| Haferkamp, G | 1 |
| Regli, F | 1 |
| Simon, O | 2 |
| Mertin, J | 2 |
| Brass, B | 1 |
| Baethmann, A | 3 |
| Koczorek, KR | 2 |
| Nisch, G | 1 |
| Schmiedek, P | 2 |
| Merrem, B | 1 |
| Rost, W | 1 |
| Fukuchi, S | 1 |
| Thilman, J | 1 |
| Zeumer, H | 1 |
| Lanksch, W | 1 |
| Brendel, W | 1 |
| Enzenbach, R | 1 |
| Oelert, H | 1 |
| Larcan, A | 1 |
| Calamai, M | 1 |
| Jacob, F | 1 |
| Schmidt, P | 1 |
| Ravon, R | 2 |
| Imbert, D | 1 |
| Guibert, B | 1 |
| Fischer, G | 2 |
| Mansuy, L | 2 |
| Bret, P | 1 |
| Wesemann, W | 1 |
| Kirschstein, H | 1 |
| Christensen, BE | 1 |
3 reviews available for spironolactone and Brain Edema
| Article | Year |
|---|---|
[New clinical application of spironolactone].
Topics: Adrenal Glands; Adult; Antihypertensive Agents; Ascites; Brain Edema; Diuretics; Edema; Female; Huma | 1974 |
[Pathophysiology of traumatic brain edema. Findings and hypotheses].
Topics: Acid-Base Equilibrium; Aldosterone; Animals; Brain Edema; Brain Injuries; Humans; Mineralocorticoid | 1970 |
[Aldosterone and aldosterone antagonists in surgery].
Topics: Adult; Aldosterone; Blood Volume; Brain Edema; Cardiac Surgical Procedures; Child; Digitalis Glycosi | 1971 |
3 trials available for spironolactone and Brain Edema
| Article | Year |
|---|---|
[Effects of furosemide, spironolactone and 6-methylprednisolone on cerebrospinal fluid pressure. Contribution to the treatment of brain edema].
Topics: Brain Edema; Furosemide; Humans; Intracranial Pressure; Methylprednisolone; Spironolactone | 1982 |
Treatment of cerebral infarcts with anti-oedema agents.
Topics: Adrenocorticotropic Hormone; Aged; Brain Edema; Cerebral Infarction; Cosyntropin; Glycerol; Humans; | 1979 |
[Therapy of traumatic brain edema with spironolactone (author's transl)].
Topics: Adolescent; Adult; Brain; Brain Edema; Brain Injuries; Clinical Trials as Topic; Double-Blind Method | 1979 |
20 other studies available for spironolactone and Brain Edema
| Article | Year |
|---|---|
Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression.
Topics: Acid Sensing Ion Channel Blockers; Animals; Aquaporin 4; Brain Edema; Cells, Cultured; Corticosteron | 2016 |
[Prevention of brain edema. After acute hypertonic dehydration by dexamethasone, aldosterone and spirolactone during rehydration].
Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Chemistry; Brain Edema; Desiccation; Dexamethasone; | 1981 |
[Drug treatment of brain edema].
Topics: Adrenocorticotropic Hormone; Aldosterone; Barbiturates; Blood-Brain Barrier; Brain Edema; Cerebrovas | 1983 |
[Normovolemic hemodilution and cerebral edema].
Topics: Animals; Brain Edema; Dexamethasone; Dogs; Hematocrit; Hemodilution; Intracranial Pressure; Mannitol | 1982 |
[Letter: The treatment of brain edema during hepatic coma].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Brain Edema; Female; Hepatic Encephalopathy; Hepatit | 1975 |
[Modern pathophysiological aspects regarding the treatment of brain edema (author's transl)].
Topics: Aldosterone; Brain Abscess; Brain Edema; Brain Injuries; Brain Neoplasms; Cerebral Ventricles; Dexam | 1978 |
[EEG changes following spirolactone treatment (author's transl)].
Topics: Aldosterone; Brain Edema; Canrenoic Acid; Electroencephalography; Encephalitis; Female; Humans; Male | 1978 |
[Letter: Spironolactone and aldosterone in brain edema].
Topics: Aldosterone; Brain Edema; Humans; Spironolactone | 1975 |
[Prevention of brain edema and dehydrating therapy in acute brain injury].
Topics: Brain; Brain Edema; Brain Injuries; Fructose; Glucose; Mannitol; Osmolar Concentration; Oxygen; Sorb | 1975 |
Disturbances of electrical activity of the brain induced by the spirolactone derivative potassium canrenoate.
Topics: Adrenal Glands; Adrenalectomy; Adult; Aldosterone; Animals; Brain; Brain Edema; Cortical Synchroniza | 1973 |
[Soludactone and neurosurgical recovery].
Topics: Adrenal Cortex Hormones; Blood Gas Analysis; Brain Diseases; Brain Edema; Brain Injuries; Brain Neop | 1974 |
[Influencing postoperative water-electrolyte imbalance with spironolactone (verospirone)].
Topics: Brain Edema; Dose-Response Relationship, Drug; Humans; Neurosurgery; Postoperative Complications; Po | 1974 |
[Treatment of cerebral oedema with high doses of furosemide (author's transl)].
Topics: Brain Edema; Cerebrospinal Fluid; Diuresis; Electroencephalography; Female; Furosemide; Humans; Inje | 1974 |
Formation and treatment of cerebral edema.
Topics: Aldosterone; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Dexamethasone; Ethacrynic Ac | 1974 |
[Severe kaliopenia and electrolytic gradient disturbances in medico-surgical resuscitation. Value of a spironolactone with antialdosterone and catatoxic effect].
Topics: Brain Edema; Cardiac Surgical Procedures; Cardiovascular Diseases; Extracorporeal Circulation; Human | 1971 |
[Diuresis and diuretics].
Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder | 1971 |
[1st results of the use of Soludactone in the treatment of certain forms of cerebral edema].
Topics: Adolescent; Adult; Aged; Aldosterone; Brain Edema; Female; Humans; Hyperaldosteronism; Male; Middle | 1970 |
[Cerebral edema and hyperaldosteronism].
Topics: Brain Edema; Brain Injuries; Humans; Hyperaldosteronism; Potassium; Sodium; Spironolactone | 1970 |
[Experimental and electron microscopical studies on the pathogenesis of brain edema].
Topics: Animals; Brain; Brain Edema; Dexamethasone; Microscopy, Electron; Rats; Spironolactone | 1970 |
[Metyrapone incombination with spironolactone and prednisone in the therapy of severe edema].
Topics: Aged; Brain Edema; Drug Synergism; Edema; Female; Humans; Hyperkalemia; Hyponatremia; Metyrapone; Mi | 1968 |