spironolactone has been researched along with Bone Loss, Osteoclastic in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that aldosteronism is accompanied by hypercalciuria and hypermagnesuria that lead to bone loss, which could be rescued by hydrochlorothiazide and spironolactone." | 3.73 | Bone loss in rats with aldosteronism. ( Bhattacharya, SK; Chhokar, VS; Runyan, AL; Runyan, JW; Sun, Y; Weber, KT, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chhokar, VS | 2 |
| Sun, Y | 2 |
| Bhattacharya, SK | 2 |
| Ahokas, RA | 1 |
| Myers, LK | 1 |
| Xing, Z | 1 |
| Smith, RA | 1 |
| Gerling, IC | 1 |
| Weber, KT | 2 |
| Runyan, AL | 1 |
| Runyan, JW | 1 |
| Moghetti, P | 1 |
| Castello, R | 1 |
| Zamberlan, N | 1 |
| Rossini, M | 1 |
| Gatti, D | 1 |
| Negri, C | 1 |
| Tosi, F | 1 |
| Muggeo, M | 1 |
| Adami, S | 1 |
| Lagrue, G | 1 |
| Fournier, A | 1 |
1 trial available for spironolactone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Spironolactone, but not flutamide, administration prevents bone loss in hyperandrogenic women treated with gonadotropin-releasing hormone agonist.
Topics: Adult; Bone and Bones; Bone Density; Bone Resorption; Female; Flutamide; Hirsutism; Humans; Polycyst | 1999 |
3 other studies available for spironolactone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Hyperparathyroidism and the calcium paradox of aldosteronism.
Topics: Aldosterone; Animals; Bone Density; Bone Resorption; Calcium; Hyperaldosteronism; Hyperparathyroidis | 2005 |
Bone loss in rats with aldosteronism.
Topics: Animals; Bone Resorption; Calcium; Hydrochlorothiazide; Hyperaldosteronism; Magnesium; Male; Parathy | 2005 |
[Nephrology in 1972].
Topics: Bone Resorption; Calcium; Dextrans; Female; Fluorescent Antibody Technique; Gentamicins; Glomerulone | 1972 |