spironolactone has been researched along with Blood Pressure, Low in 17 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to investigate the appropriateness and complications of the use of spironolactone for heart failure (HF) in clinical practice." | 9.10 | Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. ( Agoston, I; Bozkurt, B; Knowlton, AA, 2003) |
| "Treatment with spironolactone aims to attenuate androgen-mediated conditions including acne, hidradenitis suppurativa, female pattern hair loss and hirsutism." | 6.66 | Spironolactone in dermatology: uses in acne and beyond. ( Al-Niaimi, F; Ali, FR; Searle, TN, 2020) |
| " This study evaluated whether hyperkalemia and/or hypotension limited the use of eplerenone, a selective mineralocorticoid receptor antagonist, in hemodialysis patients." | 5.20 | The Safety of Eplerenone in Hemodialysis Patients: A Noninferiority Randomized Controlled Trial. ( Bosch, J; Bueti, J; Devereaux, PJ; Gao, P; Garg, AX; Manns, B; Rabbat, C; Smyth, A; Tyrwhitt, J; Wald, R; Walsh, M, 2015) |
| "This study was designed to investigate the appropriateness and complications of the use of spironolactone for heart failure (HF) in clinical practice." | 5.10 | Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. ( Agoston, I; Bozkurt, B; Knowlton, AA, 2003) |
| "The addition of enalapril or acebutolol to a regimen of altizide + spironolactone in patients with moderate hypotension was investigated in a multicenter study of 53 patients." | 5.06 | Spironolactone and altizide used in combination with enalapril: twenty-four-hour ambulatory recording of blood pressure. ( Capron, MH; Pelletier, B; Poncelet, P; Wehrlen, M, 1990) |
| "In 3 patients with severe cardiac failure high dose therapy with the ACE inhibitor enalapril was instituted during a state of extracellular volume depletion." | 3.67 | [Severe complications during enalapril therapy for heart insufficiency]. ( Stäubli, M; Wieland, T, 1988) |
| " Spironolactone appears safe in carefully monitored maintenance hemodialysis patients, but did not affect cardiovascular parameters in this small study." | 2.90 | Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial. ( Anderson, AH; Charytan, DM; Dember, LM; DiCarli, M; Himmelfarb, J; Hsu, JY; Hung, AM; Ikizler, TA; Kimmel, PL; Kliger, AS; Landis, JR; Mehrotra, R; Raj, DS; Sharma, S; Skali, H; Weiner, DE; Williams, M, 2019) |
| "Treatment with spironolactone aims to attenuate androgen-mediated conditions including acne, hidradenitis suppurativa, female pattern hair loss and hirsutism." | 2.66 | Spironolactone in dermatology: uses in acne and beyond. ( Al-Niaimi, F; Ali, FR; Searle, TN, 2020) |
| "The association between low blood pressure (BP) levels and increased mortality has been established in several studies of heart failure (HF)." | 1.35 | Association of blood pressure and its evolving changes with the survival of patients with heart failure. ( Almendral, J; Bardaji, A; Bayes-Genis, A; Cinca, J; de Luna, AB; Fernandez-Palomeque, C; Gonzalez-JuAnatey, JR; Grigorian-Shamagian, L; Jimenez, RP; Macaya, C; Nieto, V; Pascual, D; Vazquez, R, 2008) |
| "Glucocorticoid-remediable aldosteronism (GRA) is a rarely recognised cause of arterial hypertension." | 1.30 | Abolished nocturnal blood pressure fall in a boy with glucocorticoid-remediable aldosteronism. ( Bernhardt, R; Hampf, M; Seeman, T; Widimský, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Buncha, V | 1 |
| Cherezova, A | 1 |
| Alexander, S | 1 |
| Baranovskaya, I | 1 |
| Coleman, KA | 1 |
| Cherian-Shaw, M | 1 |
| Brands, MW | 1 |
| Sullivan, JC | 1 |
| O'Connor, PM | 1 |
| Mamenko, M | 1 |
| Searle, TN | 1 |
| Al-Niaimi, F | 1 |
| Ali, FR | 1 |
| Charytan, DM | 1 |
| Himmelfarb, J | 1 |
| Ikizler, TA | 1 |
| Raj, DS | 1 |
| Hsu, JY | 1 |
| Landis, JR | 1 |
| Anderson, AH | 1 |
| Hung, AM | 1 |
| Mehrotra, R | 1 |
| Sharma, S | 1 |
| Weiner, DE | 1 |
| Williams, M | 1 |
| DiCarli, M | 1 |
| Skali, H | 1 |
| Kimmel, PL | 1 |
| Kliger, AS | 1 |
| Dember, LM | 1 |
| Walsh, M | 1 |
| Manns, B | 1 |
| Garg, AX | 1 |
| Bueti, J | 1 |
| Rabbat, C | 1 |
| Smyth, A | 1 |
| Tyrwhitt, J | 1 |
| Bosch, J | 1 |
| Gao, P | 1 |
| Devereaux, PJ | 1 |
| Wald, R | 1 |
| Grigorian-Shamagian, L | 1 |
| Gonzalez-JuAnatey, JR | 1 |
| Vazquez, R | 1 |
| Cinca, J | 1 |
| Bayes-Genis, A | 1 |
| Pascual, D | 1 |
| Fernandez-Palomeque, C | 1 |
| Bardaji, A | 1 |
| Almendral, J | 1 |
| Nieto, V | 1 |
| Macaya, C | 1 |
| Jimenez, RP | 1 |
| de Luna, AB | 1 |
| Kato, J | 1 |
| Mori, T | 1 |
| Nakamura, Y | 1 |
| Sakurai, M | 1 |
| Aisa, Y | 1 |
| Ikeda, Y | 1 |
| Okamoto, S | 1 |
| Bozkurt, B | 1 |
| Agoston, I | 1 |
| Knowlton, AA | 1 |
| GREENOUGH, WB | 1 |
| SONNENBLICK, EH | 1 |
| JANUSZEWICZ, V | 1 |
| LARAGH, JH | 1 |
| McMurray, JJ | 2 |
| Pfeffer, MA | 2 |
| Swedberg, K | 2 |
| Dzau, VJ | 1 |
| Pitt, B | 1 |
| Ferrari, R | 1 |
| Gheorghiade, M | 1 |
| van Veldhuisen, DJ | 1 |
| Krum, H | 1 |
| McMurray, J | 1 |
| Lopez-Sendon, J | 1 |
| Weir, RA | 1 |
| Puu, M | 1 |
| Solomon, SD | 1 |
| Olofsson, B | 1 |
| Granger, CB | 1 |
| Yusuf, S | 1 |
| Michelson, EL | 1 |
| Seeman, T | 1 |
| Widimský, J | 1 |
| Hampf, M | 1 |
| Bernhardt, R | 1 |
| Poncelet, P | 1 |
| Wehrlen, M | 1 |
| Pelletier, B | 1 |
| Capron, MH | 1 |
| Wieland, T | 1 |
| Stäubli, M | 1 |
| Schmidt, P | 1 |
| Kopsa, H | 1 |
| Kronenberg, KH | 1 |
| Meyer, D | 1 |
| Zazgornik, J | 1 |
| Kotzaurek, R | 1 |
| Neumann, E | 1 |
| Watillon, M | 1 |
| Robe-Vanwyck, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease[NCT03020303] | Phase 3 | 2,750 participants (Anticipated) | Interventional | 2017-07-07 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for spironolactone and Blood Pressure, Low
| Article | Year |
|---|---|
Spironolactone in dermatology: uses in acne and beyond.
Topics: Acne Vulgaris; Adult; Alopecia; Dermatology; Drug Monitoring; Female; Hidradenitis Suppurativa; Hirs | 2020 |
Which inhibitor of the renin-angiotensin system should be used in chronic heart failure and acute myocardial infarction?
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Co | 2004 |
Aldosterone blockade in post-acute myocardial infarction heart failure.
Topics: Algorithms; Cardiac Output, Low; Eplerenone; Humans; Hyperkalemia; Hypotension; Mineralocorticoid Re | 2006 |
5 trials available for spironolactone and Blood Pressure, Low
| Article | Year |
|---|---|
Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial.
Topics: Adult; Aged; Aldosterone; Cardiovascular Diseases; Diastole; Dose-Response Relationship, Drug; Doubl | 2019 |
The Safety of Eplerenone in Hemodialysis Patients: A Noninferiority Randomized Controlled Trial.
Topics: Aged; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Eplerenone; Female; Hum | 2015 |
Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines.
Topics: Aged; Guideline Adherence; Heart Failure; Humans; Hyperkalemia; Hyponatremia; Hypotension; Male; Mid | 2003 |
Efficacy and tolerability of adding an angiotensin receptor blocker in patients with heart failure already receiving an angiotensin-converting inhibitor plus aldosterone antagonist, with or without a beta blocker. Findings from the Candesartan in Heart fa
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Bipheny | 2008 |
Spironolactone and altizide used in combination with enalapril: twenty-four-hour ambulatory recording of blood pressure.
Topics: Acebutolol; Benzothiadiazines; Blood Pressure; Diuretics; Drug Therapy, Combination; Enalapril; Fema | 1990 |
9 other studies available for spironolactone and Blood Pressure, Low
| Article | Year |
|---|---|
Aldosterone Antagonism Is More Effective at Reducing Blood Pressure and Excessive Renal ENaC Activity in AngII-Infused Female Rats Than in Males.
Topics: Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Diuretics; Female; Hypertension; Hypo | 2023 |
Association of blood pressure and its evolving changes with the survival of patients with heart failure.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium | 2008 |
Hypotension due to the drug interaction of voriconazole with eplerenone and nifedipine.
Topics: Antifungal Agents; Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Eplerenone | 2009 |
Correction of hyperaldosteronism and of massive fluid retention of unknown cause by sympathomimetic agents.
Topics: Amphetamine; Edema; Heart Failure; Humans; Hyperaldosteronism; Hypotension; Hypotension, Orthostatic | 1962 |
Drugs for chronic heart failure.
Topics: Adrenergic beta-Antagonists; Angioedema; Angiotensin Receptor Antagonists; Angiotensin-Converting En | 1999 |
Abolished nocturnal blood pressure fall in a boy with glucocorticoid-remediable aldosteronism.
Topics: Adolescent; Base Sequence; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Follow-Up Studie | 1999 |
[Severe complications during enalapril therapy for heart insufficiency].
Topics: Acute Kidney Injury; Drug Interactions; Enalapril; Heart Failure; Humans; Hypotension; Male; Middle | 1988 |
[Bartter's syndrome in adults. Case report with light- and electron-microscopic findings].
Topics: Adult; Alkalosis; Female; Humans; Hyperaldosteronism; Hyperplasia; Hypertrophy; Hypokalemia; Hypoten | 1973 |
[Harmful effects of common drugs on the visual apparatus. Diuretics].
Topics: Antihypertensive Agents; Carbonic Anhydrase Inhibitors; Diuretics; Drug Synergism; Eye Diseases; Hum | 1972 |