spironolactone has been researched along with Blood Clot in 9 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The Eplerenone Neurohormonal Efficacy and Survival Study (EPHESUS) with eplerenone in patients who were post-myocardial infarction underscores the additive benefit of such a strategy in post-infarction patients that typify an at-risk population for recurrent cardiovascular events." | 8.82 | Eplerenone: will it have a role in the treatment of acute coronary syndromes? ( Meier, DJ; Pitt, B; Rajagopalan, S, 2004) |
| " Longer duration or higher dosage of spironolactone seems to be more effective in improving cardiovascular system status in PD patients." | 5.46 | Aldosterone antagonist therapy and its relationship with inflammation, fibrosis, thrombosis, mineral-bone disorder and cardiovascular complications in peritoneal dialysis (PD) patients. ( Donderski, R; Grajewska, M; Manitius, J; Miśkowiec, I; Odrowąż-Sypniewska, G; Siódmiak, J; Stefańska, A; Stróżecki, P; Sulikowska, B, 2017) |
| " The Eplerenone Neurohormonal Efficacy and Survival Study (EPHESUS) with eplerenone in patients who were post-myocardial infarction underscores the additive benefit of such a strategy in post-infarction patients that typify an at-risk population for recurrent cardiovascular events." | 4.82 | Eplerenone: will it have a role in the treatment of acute coronary syndromes? ( Meier, DJ; Pitt, B; Rajagopalan, S, 2004) |
| " Therefore, the mechanism of aldosterone prothrombotic action is multiple and involves primary haemostasis activation, procoagulative and antifibrinolytic action, NO bioavailability impairment and oxidative stress augmentation." | 2.46 | [Prothrombotic aldosterone action--a new side of the hormone]. ( Chabielska, E; Gromotowicz, A; Mantur, M; Osmólska, U; Szemraj, J; Szoka, P; Zakrzeska, A, 2010) |
| " Longer duration or higher dosage of spironolactone seems to be more effective in improving cardiovascular system status in PD patients." | 1.46 | Aldosterone antagonist therapy and its relationship with inflammation, fibrosis, thrombosis, mineral-bone disorder and cardiovascular complications in peritoneal dialysis (PD) patients. ( Donderski, R; Grajewska, M; Manitius, J; Miśkowiec, I; Odrowąż-Sypniewska, G; Siódmiak, J; Stefańska, A; Stróżecki, P; Sulikowska, B, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z | 1 |
| Luo, X | 1 |
| Liu, M | 1 |
| Jiang, J | 1 |
| Li, Y | 1 |
| Huang, Z | 1 |
| Wang, L | 1 |
| Cao, J | 1 |
| He, L | 1 |
| Huang, S | 1 |
| Hu, H | 1 |
| Li, L | 1 |
| Chen, L | 1 |
| Olatunji, LA | 1 |
| Usman, TO | 1 |
| Akinade, AI | 1 |
| Adeyanju, OA | 1 |
| Kim, I | 1 |
| Soladoye, AO | 1 |
| Donderski, R | 1 |
| Stróżecki, P | 1 |
| Sulikowska, B | 1 |
| Grajewska, M | 1 |
| Miśkowiec, I | 1 |
| Stefańska, A | 1 |
| Siódmiak, J | 1 |
| Odrowąż-Sypniewska, G | 1 |
| Manitius, J | 1 |
| Zakrzeska, A | 2 |
| Gromotowicz-Popławska, A | 1 |
| Szemraj, J | 3 |
| Szoka, P | 2 |
| Kisiel, W | 1 |
| Purta, T | 1 |
| Kasacka, I | 1 |
| Chabielska, E | 3 |
| Gromotowicz, A | 2 |
| Osmólska, U | 1 |
| Mantur, M | 1 |
| Meier, DJ | 1 |
| Pitt, B | 1 |
| Rajagopalan, S | 1 |
| Stankiewicz, A | 1 |
| Wojewódzka-Zelezniakowicz, M | 1 |
| Skrzypkowski, P | 1 |
| Levin, SE | 1 |
| Zamit, R | 1 |
| Schmaman, A | 1 |
| Cohen, LS | 1 |
3 reviews available for spironolactone and Blood Clot
| Article | Year |
|---|---|
[Prothrombotic aldosterone action--a new side of the hormone].
Topics: Aldosterone; Animals; Eplerenone; Hemostasis; Platelet Adhesiveness; Rats; Spironolactone; Thrombosi | 2010 |
Eplerenone: will it have a role in the treatment of acute coronary syndromes?
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Collagen; Coronary Restenosis; Eplerenone; Humans; | 2004 |
Clinical pharmacology of acetylsalicylic acid.
Topics: Absorption; Aspirin; Blood Platelets; Digestive System; Drug Combinations; Drug Hypersensitivity; He | 1976 |
6 other studies available for spironolactone and Blood Clot
| Article | Year |
|---|---|
Elabela-apelin-12, 17, 36/APJ system promotes platelet aggregation and thrombosis via activating the PANX1-P2X7 signaling pathway.
Topics: Animals; Apelin; Apelin Receptors; Cerebral Infarction; Peptide Hormones; Platelet Aggregation; Sign | 2023 |
Low-dose spironolactone ameliorates insulin resistance and suppresses elevated plasminogen activator inhibitor-1 during gestational testosterone exposure.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Drinking; Dyslipi | 2017 |
Aldosterone antagonist therapy and its relationship with inflammation, fibrosis, thrombosis, mineral-bone disorder and cardiovascular complications in peritoneal dialysis (PD) patients.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Biomarkers; Blood Pressure; Cardiovascular Diseases; Ch | 2017 |
Eplerenone reduces arterial thrombosis in diabetic rats.
Topics: Animals; Carotid Arteries; Diabetes Mellitus, Experimental; Eplerenone; Hemostasis; Interleukins; Ma | 2015 |
Acute aldosterone infusion enhances thrombosis development in normotensive rats.
Topics: Aldosterone; Animals; Blood Coagulation; Blood Pressure; Carboxypeptidase B2; Disease Models, Animal | 2007 |
Thrombosis of the pulmonary arteries and the nephrotic syndrome.
Topics: Child, Preschool; Humans; Male; Nephrotic Syndrome; Prednisone; Pulmonary Artery; Spironolactone; Th | 1967 |