spironolactone has been researched along with Bipolar Disorder in 9 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study is to determine if spironolactone as an adjunctive therapy is effective in improving residual symptoms in bipolar disorder." | 3.75 | Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series. ( Belmonte-de-Abreu, PS; Berk, M; Gama, CS; Juruena, MF, 2009) |
| "86), and chronic use of spironolactone (OR, 2." | 1.37 | Risk factors for bullous pemphigoid in the elderly: a prospective case-control study. ( Bastuji-Garin, S; Bedane, C; Bernard, P; Delaporte, E; Dutronc, Y; Guillaume, JC; Ingen-Housz-Oro, S; Joly, P; Lemordant, P; Maillard, H; Pauwels, C; Picard-Dahan, C; Richard, MA; Roujeau, JC; Sparsa, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Juruena, MF | 1 |
| Gama, CS | 1 |
| Berk, M | 1 |
| Belmonte-de-Abreu, PS | 1 |
| Bastuji-Garin, S | 1 |
| Joly, P | 1 |
| Lemordant, P | 1 |
| Sparsa, A | 1 |
| Bedane, C | 1 |
| Delaporte, E | 1 |
| Roujeau, JC | 1 |
| Bernard, P | 1 |
| Guillaume, JC | 1 |
| Ingen-Housz-Oro, S | 1 |
| Maillard, H | 1 |
| Pauwels, C | 1 |
| Picard-Dahan, C | 1 |
| Dutronc, Y | 1 |
| Richard, MA | 1 |
| Aron, DC | 1 |
| Tyrrell, JB | 1 |
| Fitzgerald, PA | 1 |
| Findling, JW | 1 |
| Forsham, PH | 1 |
| Hendler, NH | 1 |
| Gillman, MA | 1 |
| Lichtigfeld, FJ | 1 |
| Lerer, B | 1 |
| Baer, L | 1 |
| Platman, SR | 1 |
| Kassir, S | 1 |
| Fieve, RR | 1 |
| Demers, RG | 1 |
| Hendler, R | 1 |
| Allen, RP | 1 |
| Boyd, J | 1 |
| Demers, R | 1 |
| Heninger, G | 1 |
1 review available for spironolactone and Bipolar Disorder
| Article | Year |
|---|---|
Alternative therapies for bipolar disorder.
Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgylin | 1985 |
8 other studies available for spironolactone and Bipolar Disorder
| Article | Year |
|---|---|
Improved stress response in bipolar affective disorder with adjunctive spironolactone (mineralocorticoid receptor antagonist): case series.
Topics: Adult; Bipolar Disorder; Female; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Mineralo | 2009 |
Risk factors for bullous pemphigoid in the elderly: a prospective case-control study.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Bed Rest; Bipolar Disorder; Case-Control Studies; Cog | 2011 |
Cushing's syndrome: problems in diagnosis.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult; | 1981 |
Spironolactone prophylaxis in manic-depressive disease.
Topics: Adult; Bipolar Disorder; Cell Membrane Permeability; Female; Follow-Up Studies; Humans; Hypothalamus | 1978 |
Synergism of spironolactone and lithium in mania.
Topics: Adult; Bipolar Disorder; Drug Synergism; Female; Humans; Lithium; Spironolactone | 1986 |
Mechanisms of renal lithium handling and their relationship to mineralocorticoids: a dissociation between sodium and lithium ions.
Topics: Absorption; Adult; Aged; Animals; Biological Transport, Active; Bipolar Disorder; Chlorothiazide; Cr | 1971 |
Edema and increased plasma renin activity in lithium treated patients.
Topics: Adult; Affective Symptoms; Aldosterone; Anxiety; Bipolar Disorder; Carbonates; Chlorpromazine; Diet; | 1971 |
Pretibial edema and sodium retention during lithium carbonate treatment.
Topics: Adult; Age Factors; Aldosterone; Bipolar Disorder; Body Weight; Carbonates; Diet; Edema; Female; Hum | 1970 |