spironolactone has been researched along with Atrial Remodeling in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Atrial Remodeling: Long-term changes in the electrophysiological parameters and/or anatomical structures of the HEART ATRIA that result from prolonged changes in atrial rate, often associated with ATRIAL FIBRILLATION or long periods of intense EXERCISE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aldosterone inhibitor eplerenone (EPL) has been shown to reduce the incidence of atrial fibrillation (AF) in patients with systolic heart failure, but the mechanism is unknown." | 7.85 | Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling. ( Berenfeld, O; Ennis, SR; Guerrero-Serna, G; Jalife, J; Kaur, K; Ponce-Balbuena, D; Ramirez, RJ; Ramos-Mondragón, R; Salvador-Montañés, O; Takemoto, Y, 2017) |
| "This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP)." | 7.83 | Effects of spironolactone towards rabbit atrial remodeling with rapid pacing. ( Gu, L; Huang, MX; Li, H; Wang, LF; Zhang, BZ; Zhou, WB, 2016) |
| "The aldosterone inhibitor eplerenone (EPL) has been shown to reduce the incidence of atrial fibrillation (AF) in patients with systolic heart failure, but the mechanism is unknown." | 3.85 | Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling. ( Berenfeld, O; Ennis, SR; Guerrero-Serna, G; Jalife, J; Kaur, K; Ponce-Balbuena, D; Ramirez, RJ; Ramos-Mondragón, R; Salvador-Montañés, O; Takemoto, Y, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanders, P | 1 |
| Elliott, AD | 1 |
| Linz, D | 1 |
| Takemoto, Y | 1 |
| Ramirez, RJ | 1 |
| Kaur, K | 1 |
| Salvador-Montañés, O | 1 |
| Ponce-Balbuena, D | 1 |
| Ramos-Mondragón, R | 1 |
| Ennis, SR | 1 |
| Guerrero-Serna, G | 1 |
| Berenfeld, O | 1 |
| Jalife, J | 1 |
| Wang, LF | 1 |
| Gu, L | 1 |
| Huang, MX | 1 |
| Zhou, WB | 1 |
| Li, H | 1 |
| Zhang, BZ | 1 |
3 other studies available for spironolactone and Atrial Remodeling
| Article | Year |
|---|---|
Upstream Targets to Treat Atrial Fibrillation.
Topics: Atrial Fibrillation; Atrial Remodeling; Eplerenone; Heart Atria; Humans; Spironolactone | 2017 |
Eplerenone Reduces Atrial Fibrillation Burden Without Preventing Atrial Electrical Remodeling.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Cardiac Pacing, Artificial; Eplerenone; Fibrosis; M | 2017 |
Effects of spironolactone towards rabbit atrial remodeling with rapid pacing.
Topics: Animals; Atrial Remodeling; Calcium Channels, L-Type; Cardiac Pacing, Artificial; Female; Male; Rabb | 2016 |