spironolactone and Ascites studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Research Excerpts

Excerpt	Relevance	Reference
"Eplerenone and spironolactone are equally effective in management of ascites due to liver cirrhosis but side effect profile of eplerenone scores over Spironolactone."	9.34	Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver. ( Sehgal, R; Singh, H; Singh, IP, 2020)
" Patients without hyperkalemia were administrated 100 mg of spironolactone/day."	9.22	High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis. ( Demir, M; Dogan, O; Ozer, B; Parlakgumus, A; Serin, E; Yakar, T, 2016)
"To investigate the short-term effects of satavaptan, a selective vasopressin V2 receptor antagonist on ascites in cirrhosis without hyponatraemia."	9.14	Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia--a randomized, double-blind, placebo-controlled study. ( Bruha, R; Dudley, F; Ginès, P; Terg, R; Watson, H; Wong, F; Zarski, JP, 2010)
" To investigate the effects of the addition of a vasopressin V(2) receptor antagonist, satavaptan, to 100mg spironolactone on ascites recurrence after a large volume paracentesis in patients with liver cirrhosis irrespective of the presence of hyponatraemia."	9.14	Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis. ( Angeli, P; Bernardi, M; Gines, P; Gow, P; Horsmans, Y; Minini, P; Watson, H; Wong, F, 2010)
"Paracentesis is more effective for short-term treatment of ascites but clonidine-spironolactone association might provide better long-term control."	9.11	Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. ( Codden, T; Henry, JP; Legros, F; Lenaerts, A; Ligny, G, 2005)
"The most rational treatment of moderate ascites is spironolactone alone or in combination with furosemide."	9.10	Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. ( Cabré, E; Durández, R; Gassull, MA; Granada, ML; Jiménez, JA; Morillas, RM; Pardo, A; Planas, R; Quintero, E; Santos, J, 2003)
"The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated."	9.08	The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996)
"Fifteen patients with newly diagnosed cirrhotic ascites were randomized to receive either 100 mg spironolactone daily for 7 days or 250 mg theophylline on days 1, 2, 4 and 6."	9.08	Comparison between theophylline and spironolactone in the management of cirrhotic ascites: a randomized controlled study. ( Dabos, KJ; Forrest, EH; Hayes, PC; MacGilchrist, AJ; Stanley, AJ, 1998)
"This study evaluated the dose-response relationship of torsemide, the first pyridine-sulphonylurea loop diuretic, in patients with ascites due to cirrhosis."	9.07	A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis. ( Applefeld, JJ; Dukes, GE; Hak, LJ; Kasmer, RJ; McClain, CJ; Wermeling, DP, 1994)
"Tolvaptan is a new drug used for treating ascites induced by liver cirrhosis, and it is covered by health insurance in Japan."	7.81	Re-response to tolvaptan after furosemide dose reduction in a patient with refractory ascites. ( Goto, A; Matsumoto, M; Nakamura, M; Sakaida, I; Terai, S, 2015)
"We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics."	7.67	Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986)
"In cirrhotic patients low-dose captopril seems to be efficient in the treatment of ascites resistant to diuretics without causing major side effects."	7.67	[Effect of captopril therapy on sodium and water excretion in patients with liver cirrhosis and ascites]. ( Brunkhorst, R; Koch, K; Kühn, K; Schmidt, FW; Wrenger, E, 1989)
"The effect of spironolactone on the urinary excretion of prostaglandins was studied in patients with liver cirrhosis and ascites."	7.67	Effect of spironolactone on renal prostaglandin excretion in patients with liver cirrhosis and ascites. ( Guarner, F; Medina, JF; Milazzo, A; Prieto, J; Quiroga, J, 1986)
"Ten patients with ascites due to chronic liver disease were treated with spironolactone as the sole diuretic in doses of 300 to 600 mg daily."	7.66	Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. ( Campra, JL; Reynolds, TB, 1978)
"Thirteen of 15 patients with malignant ascites achieved an excellent response to spironolactone, with an increase in urinary sodium excretion rates from less than 35 mEq/d before treatment to between 50 and 245 mEq/d after treatment."	7.66	Control of malignant ascites with spironolactone. ( Greenway, B; Johnson, PJ; Williams, R, 1982)
"Twenty patients with cirrhosis and ascites but no renal failure were given piretanide, a new loop diuretic, in order to investigate its efficacy and to relate the diuretic response with the pretreatment plasma aldosterone concentration."	7.66	Use of piretanide, a new loop diuretic, in cirrhosis with ascites: relationship between the diuretic response and the plasma aldosterone level. ( Arroyo, V; Bosch, J; Cabrera, J; Casamitjana, R; Rivera, F; Rodés, J, 1980)
""Refractory" ascites was drained off by combinations of antialdosterone (spironolactone, canrenone) and pseudoantialdosterone (triamterene, amiloride) drugs inducing as high sodium excretion as 100 mEq per day in two patients with liver cirrhosis kept on a 9 mEq Na diet."	7.65	Reversal of the suppressed potassium excretion during treatment with combinations of antikaliuretic drugs (spironolactone, canrenone, triamterene, amiloride) in patients with liver cirrhosis. ( Juhos, E; Radó, JP; Sawinsky, I, 1976)
"Potassium excretion was enhanced by spironolactone and it was inhibited by amiloride in a patient with ascites."	7.65	Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis. ( Juhos, E; Radó, JP, 1976)
" To develop an effective but safe regimen for treatment of cirrhotic ascites, a two-part crossover study was done."	6.64	An optimal diuretic regimen for cirrhotic ascites. A controlled trial evaluating safety and efficacy of spironolactone and furosemide. ( Fuller, RK; Gobezie, GC; Khambatta, PB, 1977)
"Coexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV."	5.46	Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma. ( Goya, T; Kato, M; Kohjima, M; Kotoh, K; Masumoto, A; Miyazaki, M; Motomura, K; Senjyu, T; Tanaka, K; Yada, M, 2017)
"Eplerenone and spironolactone are equally effective in management of ascites due to liver cirrhosis but side effect profile of eplerenone scores over Spironolactone."	5.34	Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver. ( Sehgal, R; Singh, H; Singh, IP, 2020)
"The intent of this study was to identify pharmacokinetic and pharmacodynamic characteristics for spironolactone (SP) and its metabolites (canrenone, 6 beta-hydroxy-7 alpha-thiomethylspirolactone, 7 alpha-thiomethylspirolactone) in cirrhotics under steady state conditions."	5.28	Spironolactone pharmacokinetics and pharmacodynamics in patients with cirrhotic ascites. ( Bartle, WR; DeAngelis, C; Pappas, C; Sungaila, I; Uetrecht, J; Vidins, E; Walker, SE, 1992)
" Mean plasma half-life of muzolimine in these patients with liver cirrhosis was 7."	5.26	[Pharmacodynamic and pharmacokinetic studies of muzolimine in patients with hepatogeneous ascites (author's transl)]. ( Dýcka, J; Loew, D; Pfleiderer, T; Ritter, W, 1980)
" A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined."	5.25	Spironolactone diuresis in patients with cirrhosis and ascites. ( Eggert, RC, 1970)
" Patients without hyperkalemia were administrated 100 mg of spironolactone/day."	5.22	High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis. ( Demir, M; Dogan, O; Ozer, B; Parlakgumus, A; Serin, E; Yakar, T, 2016)
"To investigate the short-term effects of satavaptan, a selective vasopressin V2 receptor antagonist on ascites in cirrhosis without hyponatraemia."	5.14	Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia--a randomized, double-blind, placebo-controlled study. ( Bruha, R; Dudley, F; Ginès, P; Terg, R; Watson, H; Wong, F; Zarski, JP, 2010)
" To investigate the effects of the addition of a vasopressin V(2) receptor antagonist, satavaptan, to 100mg spironolactone on ascites recurrence after a large volume paracentesis in patients with liver cirrhosis irrespective of the presence of hyponatraemia."	5.14	Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis. ( Angeli, P; Bernardi, M; Gines, P; Gow, P; Horsmans, Y; Minini, P; Watson, H; Wong, F, 2010)
"To investigate the safety and tolerability of RWJ-351647 compared with placebo after single oral dose administration to patients with cirrhosis and ascites, on a stable treatment with furosemide and spironolactone."	5.12	Oral V2 receptor antagonist (RWJ-351647) in patients with cirrhosis and ascites: a randomized, double-blind, placebo-controlled, single ascending dose study. ( Korula, J; Maheshwari, A; Parikh, C; Schrier, RW; Steare, S; Thuluvath, PJ; Wong, F; Yoo, HW, 2006)
"The effects of the addition of clonidine to diuretics on the mobilization of ascites in the short term (diuretic response and requirement of diuretics) and the long term (readmissions for tense ascites and requirement of diuretics) were examined in patients with cirrhosis and with increased sympathetic nervous system (SNS) activity."	5.12	Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system. ( Codden, T; Henry, JP; Lenaerts, A; Ligny, G; Meunier, JC, 2006)
"Twenty nonazotemic cirrhotic patients with ascites were treated with furosemide and spironolactone."	5.12	The effects of treatment with octreotide, diuretics, or both on portal hemodynamics in nonazotemic cirrhotic patients with ascites. ( Economou, M; Kalambokis, G; Kosta, P; Papadimitriou, K; Tsianos, EV, 2006)
"Paracentesis is more effective for short-term treatment of ascites but clonidine-spironolactone association might provide better long-term control."	5.11	Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. ( Codden, T; Henry, JP; Legros, F; Lenaerts, A; Ligny, G, 2005)
"The most rational treatment of moderate ascites is spironolactone alone or in combination with furosemide."	5.10	Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. ( Cabré, E; Durández, R; Gassull, MA; Granada, ML; Jiménez, JA; Morillas, RM; Pardo, A; Planas, R; Quintero, E; Santos, J, 2003)
"Five patients (three in the placebo and two in the spironolactone group) abandoned the treatment prior to ascites recurrence or the end of the study due to complications or lack of compliance."	5.08	Diuretic requirements after therapeutic paracentesis in non-azotemic patients with cirrhosis. A randomized double-blind trial of spironolactone versus placebo. ( Adler, M; Arroyo, V; Elewaut, A; Fernández-Esparrach, G; Geuvel, A; Ginès, P; Guevara, M; Jiménez, W; Lebrec, D; Pardo, A; Planas, R; Sort, P, 1997)
"The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated."	5.08	The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996)
"Fifteen patients with newly diagnosed cirrhotic ascites were randomized to receive either 100 mg spironolactone daily for 7 days or 250 mg theophylline on days 1, 2, 4 and 6."	5.08	Comparison between theophylline and spironolactone in the management of cirrhotic ascites: a randomized controlled study. ( Dabos, KJ; Forrest, EH; Hayes, PC; MacGilchrist, AJ; Stanley, AJ, 1998)
"In a prospective randomized short-term study, the efficacy and safety of xipamide and a combination of spironolactone and furosemide were compared in the treatment of hepatic cirrhotic ascites."	5.07	Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide. ( Knauf, H; Mutschler, E, 1994)
" Both drugs were administered in association with spironolactone (200 mg/day) in 28 nonazotemic cirrhotic patients with controlled ascites."	5.07	Torasemide versus furosemide in cirrhosis: a long-term, double-blind, randomized clinical study. ( Elia, G; Fiaccadori, F; Pasetti, G; Pedretti, G; Pizzaferri, P, 1993)
"This study evaluated the dose-response relationship of torsemide, the first pyridine-sulphonylurea loop diuretic, in patients with ascites due to cirrhosis."	5.07	A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis. ( Applefeld, JJ; Dukes, GE; Hak, LJ; Kasmer, RJ; McClain, CJ; Wermeling, DP, 1994)
"Forty patients with cirrhosis of the liver and tense ascites were randomized to receive either aldactone 400 mg/day and furosemide 80 mg/day (n = 20) or repeated large volume paracentesis (LVP) and infusion of low molecular weight dextran (n = 20)."	5.07	Large volume paracentesis and intravenous dextran to treat tense ascites. ( Acharya, SK; Balwinder, S; Nijhawan, S; Padhee, AK; Tandon, BN, 1992)
"In a randomized prospective study the efficacy and side effects of xipamide versus the combination spironolactone/furosemide in the treatment of cirrhotic ascites were studied."	5.06	Prediction of diuretic mobilization of cirrhotic ascites by pretreatment fractional sodium excretion. ( Gerok, W; Goerg, KJ; Knauf, H; Leser, HG; Mutschler, E; Schölmerich, J; Wenk, E, 1990)
"Two groups of patients with water retention due to ascites in cirrhosis of the liver were treated with antialdosterone diuretics (42 cases with K-canrenoate and 48 cases with spironolactone) for prolonged periods of time (an average of more than 5 months)."	5.06	[Controlled study of the effect of long-term administration of canrenoate potassium in cirrhotic ascites]. ( Traina, M; Vizzini, GB, 1986)
"Plasma levels of canrenone and androgen receptor-active materials (ARM) were determined during long-term oral K-canrenoate or spironolactone therapy in cirrhotics with chronic recurrent ascites."	5.06	Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy. ( Andriulli, A; Armanini, D; Arrigoni, A; Buzzetti, G; Gindro, T; Karbowiak, I, 1989)
"To compare the efficacy of three commonly used diuretic regimens in the treatment of ascites, we randomized 90 patients to three treatment groups: Sequential Spironolactone (spironolactone followed by furosemide if necessary), Combination (spironolactone and furosemide in combination), and Furosemide (furosemide given alone)."	5.05	Diuresis in the ascitic patient: a randomized controlled trial of three regimens. ( Fogel, MR; Gregory, PB; Knauer, CM; Miller, RG; Neal, EA; Sawhney, VK, 1981)
"Tolvaptan is a new drug used for treating ascites induced by liver cirrhosis, and it is covered by health insurance in Japan."	3.81	Re-response to tolvaptan after furosemide dose reduction in a patient with refractory ascites. ( Goto, A; Matsumoto, M; Nakamura, M; Sakaida, I; Terai, S, 2015)
"Twenty-seven patients with nonazotemic liver cirrhosis and ascites were initially treated with spironolactone, 200 mg/day."	3.70	Predictive factors influencing the therapeutic response to diuretic treatment of ascites in nonazotemic cirrhotic patients. ( Banić, M; Kujundzić, M; Ljubicić, N; Vrkljan, M, 1998)
"In cirrhotic patients low-dose captopril seems to be efficient in the treatment of ascites resistant to diuretics without causing major side effects."	3.67	[Effect of captopril therapy on sodium and water excretion in patients with liver cirrhosis and ascites]. ( Brunkhorst, R; Koch, K; Kühn, K; Schmidt, FW; Wrenger, E, 1989)
"The effect of spironolactone on the urinary excretion of prostaglandins was studied in patients with liver cirrhosis and ascites."	3.67	Effect of spironolactone on renal prostaglandin excretion in patients with liver cirrhosis and ascites. ( Guarner, F; Medina, JF; Milazzo, A; Prieto, J; Quiroga, J, 1986)
"We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics."	3.67	Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986)
"Ten patients with ascites due to chronic liver disease were treated with spironolactone as the sole diuretic in doses of 300 to 600 mg daily."	3.66	Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. ( Campra, JL; Reynolds, TB, 1978)
"Twenty patients with cirrhosis and ascites but no renal failure were given piretanide, a new loop diuretic, in order to investigate its efficacy and to relate the diuretic response with the pretreatment plasma aldosterone concentration."	3.66	Use of piretanide, a new loop diuretic, in cirrhosis with ascites: relationship between the diuretic response and the plasma aldosterone level. ( Arroyo, V; Bosch, J; Cabrera, J; Casamitjana, R; Rivera, F; Rodés, J, 1980)
" Patients with edema, ascites, or both had significantly greater elevation of plasma aldosterone levels compared to nonedematous patients; these patients also demonstrated a substantial degree of hepatic dysfunction as evidenced by lower serum albumin levels and higher bilirubin and alkaline phosphatase levels."	3.66	Hyperaldosteronism associated with liver metastases. ( Citrin, DL; Crowley, J; Pandya, KJ; Whitehead, R, 1980)
"Thirteen of 15 patients with malignant ascites achieved an excellent response to spironolactone, with an increase in urinary sodium excretion rates from less than 35 mEq/d before treatment to between 50 and 245 mEq/d after treatment."	3.66	Control of malignant ascites with spironolactone. ( Greenway, B; Johnson, PJ; Williams, R, 1982)
"Potassium excretion was enhanced by spironolactone and it was inhibited by amiloride in a patient with ascites."	3.65	Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis. ( Juhos, E; Radó, JP, 1976)
"In 8 out of 20 patients with chronic liver disease ascites was controlled with metolazone, 10 required additional amiloride or spironolactone to achieve control, and 2 were resistant to all diuretic therapy."	3.65	Use of metolazone in the treatment of ascites due to liver disease. ( Hillenbrand, P; Sherlock, S, 1971)
""Refractory" ascites was drained off by combinations of antialdosterone (spironolactone, canrenone) and pseudoantialdosterone (triamterene, amiloride) drugs inducing as high sodium excretion as 100 mEq per day in two patients with liver cirrhosis kept on a 9 mEq Na diet."	3.65	Reversal of the suppressed potassium excretion during treatment with combinations of antikaliuretic drugs (spironolactone, canrenone, triamterene, amiloride) in patients with liver cirrhosis. ( Juhos, E; Radó, JP; Sawinsky, I, 1976)
"In eight patients with cirrhosis and stable ascites controlled on chlorothiazide and spironolactone, a small particle preparation of spironolactone (Aldactone A) was as effective, at one quarter the dosage, as conventional spironolactone (Aldactone)."	3.64	A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites. ( GARSENSTEIN, M; RYDER, JA; SHALDON, S, 1963)
" To develop an effective but safe regimen for treatment of cirrhotic ascites, a two-part crossover study was done."	2.64	An optimal diuretic regimen for cirrhotic ascites. A controlled trial evaluating safety and efficacy of spironolactone and furosemide. ( Fuller, RK; Gobezie, GC; Khambatta, PB, 1977)
"Pregnancy is rare in women with decompensated chronic liver disease."	2.47	Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature. ( Hussain, R; Kamani, L; Kumar, M; Siddique, S, 2011)
"Esophagogastric varices have the greatest clinical impact, with a risk of bleeding as high as 30% within 2 years of medium or large varices developing."	2.43	Current management of the complications of portal hypertension: variceal bleeding and ascites. ( Calès, P; Dib, N; Oberti, F, 2006)
"Spironolactone has long been a standard for the treatment of cirrhotic ascites because it directly antagonizes aldosterone."	2.38	Medical treatment of ascites in cirrhosis. ( Gerbes, AL, 1993)
"Coexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV."	1.46	Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma. ( Goya, T; Kato, M; Kohjima, M; Kotoh, K; Masumoto, A; Miyazaki, M; Motomura, K; Senjyu, T; Tanaka, K; Yada, M, 2017)
"Ascites, variceal bleeding, hepatic encephalopathy, and hepatorenal syndrome are among the complications you are likely to encounter when caring for a patient with cirrhosis."	1.42	Cirrhosis complications: keeping them under control. ( Eliacin, I; Kashan, S; Minor, SE; Whisenant, EB, 2015)
" Minimum effective dosage is recommented to reduce side-effects."	1.35	[Ascites]. ( Maier, KP, 2008)
"Portopulmonary hypertension is characterized by a chronic liver disease associated with a mean pulmonary artery pressure >25 mmHg at rest, an increased pulmonary vascular resistance and a capillary pulmonary pressure <15 mmHg with portal hypertension."	1.34	[Portopulmonary hypertension due to schistosomiasis in two Malagasy patients]. ( Rajaona, HR; Rajaonarivelo, P; Ramanampamonjy, RM; Razafimahefa, SH, 2007)
"Budd-Chiari and celiac sprue association is a rare condition."	1.32	Budd-Chiari syndrome in a young patient with celiac sprue: a case report. ( Beşişik, F; Cakaloğlu, Y; Cevikbaş, U; Danalioğlu, A; Demir, K; Güngör Güllüoğlu, M; Okten, A; Poturoğlu, S, 2003)
"Ascites in liver cirrhosis is a symptom of advanced liver disease, and liver transplantation should always be considered in eligible patients."	1.31	[Therapeutic program for ascites. Recommendations from the Swedish Society of Gastroenterology and Gastrointestinal Endoscopy]. ( Lööf, L; Prytz, H; Söderlund, C; Wallerstedt, S, 2001)
"The intent of this study was to identify pharmacokinetic and pharmacodynamic characteristics for spironolactone (SP) and its metabolites (canrenone, 6 beta-hydroxy-7 alpha-thiomethylspirolactone, 7 alpha-thiomethylspirolactone) in cirrhotics under steady state conditions."	1.28	Spironolactone pharmacokinetics and pharmacodynamics in patients with cirrhotic ascites. ( Bartle, WR; DeAngelis, C; Pappas, C; Sungaila, I; Uetrecht, J; Vidins, E; Walker, SE, 1992)
" Mean plasma half-life of muzolimine in these patients with liver cirrhosis was 7."	1.26	[Pharmacodynamic and pharmacokinetic studies of muzolimine in patients with hepatogeneous ascites (author's transl)]. ( Dýcka, J; Loew, D; Pfleiderer, T; Ritter, W, 1980)
" A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined."	1.25	Spironolactone diuresis in patients with cirrhosis and ascites. ( Eggert, RC, 1970)

Timeframe	Studies, this research(%)	All Research%
pre-1990	167 (74.89)	18.7374
1990's	24 (10.76)	18.2507
2000's	14 (6.28)	29.6817
2010's	17 (7.62)	24.3611
2020's	1 (0.45)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Study for the Prevention of Ascites (SPA): Comparison of Fixed Doses of SR121463B Versus Placebo in the Reduction of Recurrence of Cirrhotic Ascites[NCT00501384]	Phase 2	151 participants (Actual)	Interventional	2004-04-30	Completed
Peritoneal Dialysis Catheters for the Treatment of Refractory Ascites Management: A Randomized Un-Blinded Pilot Study[NCT02975726]		2 participants (Actual)	Interventional	2017-01-31	Completed
Phase 4 Study on the Comparison Between Combined Versus Sequential Diuretic Treatment of Moderate Ascites in Nonazotemic Patients With Cirrhosis[NCT00741663]	Phase 4	100 participants (Anticipated)	Interventional	2005-04-30	Completed
Potential Role of Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Ascites in Cirrhotic Patients[NCT05999773]		40 participants (Anticipated)	Observational	2023-07-15	Recruiting
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.[NCT00356226]		64 participants	Interventional	2000-10-31	Completed
Comparison of Success Rate and Complication Between Conventional Angiocatheter Versus New Anchoring Device (KARAHOC) Used for Paracentesis in Cirrhotic Patients With Ascites[NCT05578573]		80 participants (Anticipated)	Interventional	2022-01-17	Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Management of ascites in cirrhotic patients. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2017, Volume: 114, Issue:1 Topics: Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Ascites; Benzazepines; Diuretics; Humans; Ja	2017
Ascites: diagnosis and management. The Medical clinics of North America, 2009, Volume: 93, Issue:4 Topics: Ascites; Ascitic Fluid; Cardiac Output; Diet, Sodium-Restricted; Disease Progression; Diuretics; Dru	2009
Management of refractory ascites. American journal of therapeutics, 2012, Volume: 19, Issue:2 Topics: Albumins; Ascites; Clonidine; Diuretics; Humans; Liver Cirrhosis; Liver Transplantation; Paracentesi	2012
Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature. European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:7 Topics: Adult; Antiviral Agents; Ascites; Blood Transfusion; Esophageal and Gastric Varices; Female; Hepatit	2011
Current management of the complications of portal hypertension: variceal bleeding and ascites. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, May-09, Volume: 174, Issue:10 Topics: Algorithms; Anti-Bacterial Agents; Ascites; Collateral Circulation; Diuretics; Endoscopy, Gastrointe	2006
[Refractory ascites: concept and therapeutic possibilities]. Medicina clinica, 1983, Jan-15, Volume: 80, Issue:1 Topics: Ascites; Ascitic Fluid; Diet, Sodium-Restricted; Furosemide; Infusions, Parenteral; Peritoneovenous	1983
Medical treatment of ascites in cirrhosis. Journal of hepatology, 1993, Volume: 17 Suppl 2 Topics: Ascites; Furosemide; Humans; Liver Cirrhosis; Spironolactone	1993
[Hyperaldosteronism, spironolactone and liver cirrhosis]. Gastroenterologia y hepatologia, 1997, Volume: 20, Issue:3 Topics: Ascites; Humans; Hyperaldosteronism; Liver Cirrhosis; Renin-Angiotensin System; Spironolactone	1997
Strategies in the treatment of ascites. Hepato-gastroenterology, 1991, Volume: 38, Issue:5 Topics: Ascites; Diet, Sodium-Restricted; Drainage; Humans; Liver Diseases; Peritoneovenous Shunt; Plasma Su	1991
Management of the patient with ascites. Postgraduate medicine, 1987, Volume: 82, Issue:5 Topics: Ascites; Bacterial Infections; Bed Rest; Diagnosis, Differential; Diuretics; Furosemide; Humans; Liv	1987
A clinical view of recent advances in ascites. Journal of clinical gastroenterology, 1986, Volume: 8, Issue:1 Topics: Animals; Ascites; Ascitic Fluid; Bacterial Infections; Blood Volume; Body Water; Extracellular Space	1986
The rational management of ascites. Progress in liver diseases, 1972, Volume: 4 Topics: Albumins; Aldosterone; Animals; Ascites; Ascitic Fluid; Diet, Sodium-Restricted; Diuretics; Dogs; Dr	1972
[New clinical application of spironolactone]. Nihon rinsho. Japanese journal of clinical medicine, 1974, Nov-10, Volume: 32, Issue:11 Topics: Adrenal Glands; Adult; Antihypertensive Agents; Ascites; Brain Edema; Diuretics; Edema; Female; Huma	1974
[Steroid spirolactones--antagonists of mineralocorticoids]. Ceskoslovenska farmacie, 1969, Volume: 18, Issue:4 Topics: Adrenalectomy; Animals; Ascites; Chemistry Techniques, Analytical; Desoxycorticosterone; Dogs; Feces	1969
Diuretics. II. Clinical considerations. Drugs, 1971, Volume: 1, Issue:2 Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I	1971

Article	Year
Comparative study of spironolactone and eplerenone in management of ascites in patients of cirrhosis of liver. European journal of gastroenterology & hepatology, 2020, Volume: 32, Issue:4 Topics: Adult; Aged; Ascites; Diet, Sodium-Restricted; Eplerenone; Female; Humans; Liver Cirrhosis; Male; Mi	2020
[Influence of non-sodium restricted diet with diuretics on plasma rennin, renal blood flow and in patients with cirrhotic ascites]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2013, Volume: 27, Issue:1 Topics: Ascites; Chymosin; Diet, Sodium-Restricted; Diuretics; Female; Furosemide; Hepatitis B; Humans; Live	2013
High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis. Clinical and investigative medicine. Medecine clinique et experimentale, 2016, Dec-01, Volume: 39, Issue:6 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Albumins; Ascites; Bilirubin; Creatinine; End	2016
Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia--a randomized, double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 2010, Volume: 31, Issue:8 Topics: Aged; Antidiuretic Hormone Receptor Antagonists; Ascites; Body Weight; Diuretics; Double-Blind Metho	2010
Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis. Journal of hepatology, 2010, Volume: 53, Issue:2 Topics: Aged; Antidiuretic Hormone Receptor Antagonists; Ascites; Combined Modality Therapy; Creatinine; Diu	2010
Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. Journal of hepatology, 2003, Volume: 39, Issue:2 Topics: Aged; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis; Ma	2003
Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. Journal of hepatology, 2003, Volume: 39, Issue:2 Topics: Aged; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis; Ma	2003
Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. Journal of hepatology, 2003, Volume: 39, Issue:2 Topics: Aged; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis; Ma	2003
Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. Journal of hepatology, 2003, Volume: 39, Issue:2 Topics: Aged; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis; Ma	2003
Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites. Gastroenterologie clinique et biologique, 2005, Volume: 29, Issue:11 Topics: Adrenergic alpha-Agonists; Ascites; Clonidine; Diuretics; Drug Resistance; Drug Therapy, Combination	2005
The effects of treatment with octreotide, diuretics, or both on portal hemodynamics in nonazotemic cirrhotic patients with ascites. Journal of clinical gastroenterology, 2006, Volume: 40, Issue:4 Topics: Adult; Aged; Aldosterone; Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Gastroi	2006
Oral V2 receptor antagonist (RWJ-351647) in patients with cirrhosis and ascites: a randomized, double-blind, placebo-controlled, single ascending dose study. Alimentary pharmacology & therapeutics, 2006, Sep-15, Volume: 24, Issue:6 Topics: Administration, Oral; Adult; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Ascite	2006
Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system. Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:4 Topics: Angiotensins; Ascites; Clonidine; Diuretics; Drug Therapy, Combination; Female; Furosemide; Heart Ra	2006
Randomized comparative study of efficacy of furosemide versus spironolactone in nonazotemic cirrhosis with ascites. Relationship between the diuretic response and the activity of the renin-aldosterone system. Gastroenterology, 1983, Volume: 84, Issue:5 Pt 1 Topics: Ascites; Clinical Trials as Topic; Diuresis; Dose-Response Relationship, Drug; Furosemide; Humans; L	1983
Comparison of six treatments of ascites in patients with liver cirrhosis. A clinical trial. Hepato-gastroenterology, 1983, Volume: 30, Issue:1 Topics: Amiloride; Ascites; Blood Chemical Analysis; Clinical Trials as Topic; Diet, Sodium-Restricted; Diur	1983
Use of diuretics in the treatment of cirrhotic ascites. Gastroenterology, 1983, Volume: 84, Issue:5 Pt 1 Topics: Ascites; Bumetanide; Diuresis; Diuretics; Dose-Response Relationship, Drug; Furosemide; Humans; Kidn	1983
Diuresis in the ascitic patient: a randomized controlled trial of three regimens. Journal of clinical gastroenterology, 1981, Volume: 3 Suppl 1 Topics: Ascites; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Female; Furosemide; Hepat	1981
Treatment of patients with IVCS and gross oedema and ascites with diuretic combination and ACE-inhibitors: relation to baseline PRA and PAC. The Netherlands journal of medicine, 1995, Volume: 46, Issue:2 Topics: Adult; Aged; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Ascites; Captopril; Diuretics; D	1995
Renal sodium handling and neurohumoral systems in patients with cirrhosis in sitting posture: effects of spironolactone and water immersion. The Clinical investigator, 1993, Volume: 71, Issue:11 Topics: Adult; Aged; Ascites; Hemodynamics; Humans; Immersion; Kidney Tubules; Liver Cirrhosis; Middle Aged;	1993
Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide. Cardiology, 1994, Volume: 84 Suppl 2 Topics: Ascites; Diuretics; Drug Administration Schedule; Drug Therapy, Combination; Female; Furosemide; Hum	1994
A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis. Alimentary pharmacology & therapeutics, 1994, Volume: 8, Issue:4 Topics: Administration, Oral; Adult; Aged; Ascites; Body Weight; Cross-Over Studies; Diuretics; Dose-Respons	1994
Diuretics vs. paracentesis followed by diuretics in cirrhosis: effect on ascites opsonic activity and immunoglobulin and complement concentrations. Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:2 Topics: Adult; Aged; Ascites; Ascitic Fluid; Blood Cell Count; Chemotherapy, Adjuvant; Complement C3; Comple	1994
Torasemide versus furosemide in cirrhosis: a long-term, double-blind, randomized clinical study. The Clinical investigator, 1993, Volume: 71, Issue:7 Topics: Ascites; Diuretics; Double-Blind Method; Drug Therapy, Combination; Furosemide; Humans; Liver Cirrho	1993
The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Ascites; Atrial Natriuretic Factor;	1996
Diuretic requirements after therapeutic paracentesis in non-azotemic patients with cirrhosis. A randomized double-blind trial of spironolactone versus placebo. Journal of hepatology, 1997, Volume: 26, Issue:3 Topics: Aldosterone; Ascites; Combined Modality Therapy; Diuretics; Dose-Response Relationship, Drug; Double	1997
Therapeutic effects of diuretics and paracentesis on lung function in patients with non-alcoholic cirrhosis and tense ascites. Journal of hepatology, 1997, Volume: 26, Issue:4 Topics: Aged; Ascites; Diuretics; Furosemide; Humans; Liver Cirrhosis; Lung; Male; Middle Aged; Paracentesis	1997
Comparison between theophylline and spironolactone in the management of cirrhotic ascites: a randomized controlled study. Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:4 Topics: Adenosine; Aged; Ascites; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Mineralocorticoid Rece	1998
An optimal diuretic regimen for cirrhotic ascites. A controlled trial evaluating safety and efficacy of spironolactone and furosemide. JAMA, 1977, Mar-07, Volume: 237, Issue:10 Topics: Ascites; Body Weight; Clinical Trials as Topic; Diuretics; Furosemide; Humans; Liver Cirrhosis; Plas	1977
[Clinical evaluation of the use of diuretics in the ascitic phase of hepatic cirrhosis]. La Clinica terapeutica, 1977, Dec-31, Volume: 83, Issue:6 Topics: Acute Disease; Adult; Aged; Amiloride; Ascites; Clinical Trials as Topic; Diuretics; Drug Evaluation	1977
[Use of demeclotetracycline in the treatment of hyponatremia in cirrhotic ascitis]. La Nouvelle presse medicale, 1977, Jan-15, Volume: 6, Issue:21 Topics: Adult; Aged; Ascites; Clinical Trials as Topic; Demeclocycline; Drug Therapy, Combination; Edema; Fe	1977
Large volume paracentesis and intravenous dextran to treat tense ascites. Journal of clinical gastroenterology, 1992, Volume: 14, Issue:1 Topics: Adult; Ascites; Combined Modality Therapy; Dextrans; Drainage; Drug Administration Schedule; Female;	1992
[Treatment of ascites in patients with liver cirrhosis without neither hyponatremia nor renal insufficiency. Results of a randomized study comparing diuretics and punctures compensated by albumin]. Gastroenterologie clinique et biologique, 1992, Volume: 16, Issue:10 Topics: Aged; Albumins; Ascites; Combined Modality Therapy; Drug Therapy, Combination; Female; Furosemide; H	1992
Short-term course of corticosteroids in the treatment of resistant ascites complicating schistosomal liver disease. The American journal of gastroenterology, 1991, Volume: 86, Issue:1 Topics: Adolescent; Adult; Aged; Ascites; Chronic Disease; Diuresis; Drug Therapy, Combination; Female; Furo	1991
Prediction of diuretic mobilization of cirrhotic ascites by pretreatment fractional sodium excretion. Klinische Wochenschrift, 1990, Jun-05, Volume: 68, Issue:11 Topics: Adult; Aged; Ascites; Creatinine; Diuretics; Drug Therapy, Combination; Female; Furosemide; Glomerul	1990
Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy. Digestion, 1989, Volume: 44, Issue:3 Topics: Adult; Aged; Ascites; Canrenoic Acid; Canrenone; Chronic Disease; Clinical Trials as Topic; Double-B	1989
Paracentesis versus diuretics in the treatment of cirrhotics with tense ascites. Lancet (London, England), 1985, Mar-16, Volume: 1, Issue:8429 Topics: Ascites; Clinical Trials as Topic; Diuretics; Female; Follow-Up Studies; Furosemide; Humans; Liver C	1985
Gynaecomastia after spironolactone and potassium canrenoate. Lancet (London, England), 1986, Mar-15, Volume: 1, Issue:8481 Topics: Ascites; Canrenoic Acid; Gynecomastia; Humans; Liver Cirrhosis; Male; Pregnadienes; Prospective Stud	1986
Bumetanide, spironolactone and a combination of the two, in the treatment of ascites due to liver disease. A prospective, controlled, randomized trial. Digestion, 1988, Volume: 41, Issue:2 Topics: Administration, Oral; Adult; Ascites; Bumetanide; Clinical Trials as Topic; Diuretics; Double-Blind	1988
The use of diuretics in preventing ascites recurrence. The British journal of clinical practice, 1988, Volume: 42, Issue:3 Topics: Adult; Aged; Ascites; Canrenoic Acid; Follow-Up Studies; Humans; Liver Cirrhosis; Male; Middle Aged;	1988
Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites. Results of a randomized study. Gastroenterology, 1987, Volume: 93, Issue:2 Topics: Albumins; Ascites; Clinical Trials as Topic; Diuretics; Drainage; Female; Follow-Up Studies; Furosem	1987
More on the comparison of paracentesis versus diuretics in the treatment of patients with tense ascites. Gastroenterology, 1988, Volume: 95, Issue:1 Topics: Ascites; Drug Therapy, Combination; Furosemide; Humans; Punctures; Spironolactone	1988
[Controlled study of the effect of long-term administration of canrenoate potassium in cirrhotic ascites]. Minerva medica, 1986, Jan-28, Volume: 77, Issue:3-4 Topics: Adult; Aged; Ascites; Canrenoic Acid; Clinical Trials as Topic; Drug Evaluation; Female; Gynecomasti	1986
Comparative efficacy of spironolactone and hydrochlorothiazide (separately and in combination) in cirrhotic edema. The Journal of the Association of Physicians of India, 1967, Volume: 15, Issue:12 Topics: Ascites; Clinical Trials as Topic; Drug Synergism; Humans; Hydrochlorothiazide; Liver Cirrhosis; Spi	1967
Amiloride (MK-870), a new antikaluretic diuretic. Comparison to other antikaluretic diuretics in patients with liver disease and ascites. Gastroenterology, 1970, Volume: 59, Issue:6 Topics: Acid-Base Equilibrium; Amidines; Ascites; Autopsy; Carcinoma; Diuretics; Ethacrynic Acid; Humans; Hy	1970

Article	Year
Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma. World journal of gastroenterology, 2017, Aug-07, Volume: 23, Issue:29 Topics: Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Ascites; Benzazepines; Body Weig	2017
Cell-free and Concentrated Ascites Reinfusion Therapy for Refractory Ascites in Cirrhosis in Post-marketing Surveillance and the Role of Tolvaptan. Internal medicine (Tokyo, Japan), 2019, Nov-01, Volume: 58, Issue:21 Topics: Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Ascites; Ascitic Fluid; Diuretic	2019
83-year-old man with abdominal swelling and lower extremity edema. Mayo Clinic proceedings, 2013, Volume: 88, Issue:10 Topics: Abdominal Cavity; Aged, 80 and over; Anti-Infective Agents; Ascites; Cefotaxime; Diagnosis, Differen	2013
Ascites in patients with cirrhosis. Canadian family physician Medecin de famille canadien, 2013, Volume: 59, Issue:12 Topics: Abdominal Pain; Aged; Analgesics, Opioid; Ascites; Catheters, Indwelling; Diet, Sodium-Restricted; D	2013
Investigation of cardiomyopathy in children with cirrhotic and noncirrhotic portal hypertension. Journal of pediatric gastroenterology and nutrition, 2015, Volume: 60, Issue:2 Topics: Adolescent; Antihypertensive Agents; Ascites; Blood Pressure; Cardiomyopathies; Case-Control Studies	2015
Re-response to tolvaptan after furosemide dose reduction in a patient with refractory ascites. Clinical journal of gastroenterology, 2015, Volume: 8, Issue:1 Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Benzazepines; Diuretics; Drug Administration Sch	2015
Cirrhosis complications: keeping them under control. The Journal of family practice, 2015, Volume: 64, Issue:6 Topics: Antihypertensive Agents; Ascites; Diuretics; Furosemide; Hemorrhage; Hepatic Encephalopathy; Humans;	2015
[Ascites]. Praxis, 2008, Jul-09, Volume: 97, Issue:14 Topics: Algorithms; Ascites; Diagnosis, Differential; Diet, Sodium-Restricted; Hepatorenal Syndrome; Humans;	2008
Liver: diuretic agents for ascites: joining forces from the start? Nature reviews. Gastroenterology & hepatology, 2010, Volume: 7, Issue:6 Topics: Ascites; Canrenoic Acid; Drug Therapy, Combination; Furosemide; Humans; Liver Cirrhosis; Mineralocor	2010
May vaptans contribute to the treatment of refractory ascites? Journal of hepatology, 2010, Volume: 53, Issue:2 Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Combined Modality Therapy; Diuretics; Dose-Respo	2010
Refractory ascites: can it be defined only by the response to furosemide and spironolactone? Liver international : official journal of the International Association for the Study of the Liver, 2010, Volume: 30, Issue:9 Topics: Ascites; Diuretics; Furosemide; Glomerular Filtration Rate; Hepatorenal Syndrome; Humans; Liver Cirr	2010
The use of a steroidal spirolactone in the treatment of ascites in hepatic cirrhosis. Lancet (London, England), 1958, Nov-22, Volume: 2, Issue:7056 Topics: Aldosterone; Ascites; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolacton	1958
[First results obtained with the use of the spirolactone SC-9420 (aldactone) in the treatment of ascites caused by liver cirrhosis]. La Riforma medica, 1960, Dec-24, Volume: 74 Topics: Ascites; Humans; Lactones; Liver Cirrhosis; Spironolactone	1960
[Trials of treatment of cirrhotic ascites with a spirolactone. Apropos of 7 cases]. Lyon medical, 1961, May-14, Volume: 93 Topics: Aldosterone; Ascites; Diuretics; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Organic Ch	1961
Spironolactone (Aldactone) therapy for ascites due to cirrhosis of the liver. Canadian Medical Association journal, 1961, Sep-09, Volume: 85 Topics: Aldosterone; Ascites; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolacton	1961
Aldactone: a physiologically new approach to the age-old problem of ascites. Research in the service of medicine, 1960, Volume: 52 Topics: Ascites; Diuretics; Humans; Spironolactone	1960
[Spirolactones in the treatment of ascitogenic hepatic cirrhosis. Clinical and biological effects]. Minerva medica, 1962, Jun-23, Volume: 53 Topics: Aldosterone; Ascites; Diuretics; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Sp	1962
[Spirolactone (Aldactone) in ascites caused by liver cirrhosis]. Nederlands tijdschrift voor geneeskunde, 1962, Jul-21, Volume: 106 Topics: Aldosterone; Ascites; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Spironolactone	1962
[Treatment of the hydrosaline retention in hepatic cirrhosis with spironolactone]. Revista medica de Chile, 1961, Volume: 89 Topics: Aldosterone; Ascites; Diuretics; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Sp	1961
[On the treatment of decompensated liver cirrhosis with spirolactone]. Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete, 1962, Volume: 43 Topics: Ascites; Chlorothiazide; Humans; Hypokalemia; Liver Cirrhosis; Spironolactone	1962
Significance of aldosterone antagonism in the treatment of edema and ascites. The American journal of medicine, 1962, Volume: 33 Topics: Aldosterone; Antihypertensive Agents; Ascites; Chlorothiazide; Diuretics; Edema; Humans; Hydrochloro	1962
Therapeutic conference on diuretics. Applied therapeutics, 1961, Volume: 3 Topics: Alcoholism; Ascites; Chlorothiazide; Diuretics; Organomercury Compounds; Prednisone; Spironolactone	1961
[On the use of spironolactone-polysorbate 80]. Minerva medica, 1963, Mar-24, Volume: 54 Topics: Ascites; Heart Failure; Humans; Polysorbates; Spironolactone	1963
Treatment of ascites in hepatic cirrhosis with the combined use of aldactone and chlorothiazide. Chinese medical journal (Peking, China : 1932), 1962, Volume: 81 Topics: Ascites; Chlorothiazide; Liver Cirrhosis; Spironolactone	1962
[Treatment with spirolactone in persistent ascites in patients with cirrhosis]. Medicina interna, 1962, Volume: 14 Topics: Ascites; Liver Cirrhosis; Spironolactone	1962
"Intractable" ascites in cirrhosis: its management by a multiple diuretic approach. The American journal of the medical sciences, 1963, Volume: 245 Topics: Ascites; Bendroflumethiazide; Disease Management; Diuretics; Humans; Hydrochlorothiazide; Hydroxypro	1963
Aldosterone antagonist (spironolactone) as an adjunct in the management of ascites in cirrhosis of the liver. Singapore medical journal, 1962, Volume: 3 Topics: Antihypertensive Agents; Ascites; Disease Management; Humans; Liver Cirrhosis; Mineralocorticoid Rec	1962
A comparison of the use of Aldactone and Aldactone A in the treatment of hepatic ascites. Gut, 1963, Volume: 4 Topics: Ascites; Chlorothiazide; Liver Cirrhosis; Spironolactone	1963
[Clinical applications of spironolactone]. Minerva medica, 1963, Mar-24, Volume: 54 Topics: Ascites; Heart Failure; Humans; Hyperaldosteronism; Spironolactone	1963
[Diuretic effect of spironolactone (Sc-9420) in patients with cirrhosis of the liver with ascites]. Revista medica de Chile, 1961, Volume: 89 Topics: Aldosterone; Ascites; Diuretics; Humans; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; Sp	1961
MANAGEMENT OF ASCITES. Archives of internal medicine, 1963, Volume: 112 Topics: Ascites; Benzothiadiazines; Disease Management; Diuresis; Humans; Liver Cirrhosis; Methylprednisolon	1963
[THE SIGNIFICANCE OF DYSREGULATION CAUSED BY DIURETICS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS]. Wiener klinische Wochenschrift, 1963, Sep-20, Volume: 75 Topics: Ascites; Diuretics; Humans; Liver Cirrhosis; Spironolactone; Toxicology; Water-Electrolyte Balance	1963
[ADMINISTRATION OF ALDACTONE (SPIRONOLACTONE) IN THE TREATMENT OF DROPSY AND ASCITES]. Suvremenna meditsina, 1963, Volume: 14 Topics: Ascites; Edema; Spironolactone	1963
THE STUDY OF THE EFFECT OF SPIROLACTONES ON ASCITES AND INTRASPLENIC PRESSURE IN BILHARZIAL LIVER CIRRHOSIS. The Journal of the Egyptian Medical Association, 1963, Volume: 46 Topics: Animals; Ascites; Benzothiadiazines; Blood Pressure; Blood Pressure Determination; Hypokalemia; Live	1963
SPIRONOLACTONE IN ASCITES OF HEPATIC CIRRHOSIS: PRELIMINARY OBSERVATIONS. Bulletin of the Calcutta School of Tropical Medicine, 1963, Volume: 11 Topics: Ascites; Ephedrine; Humans; Hydrochlorothiazide; Liver Cirrhosis; Spironolactone	1963
SPIRONOLACTONE IN REFRACTORY ASCITES IN HEPATIC CIRRHOSIS. The Journal of the Association of Physicians of India, 1963, Volume: 11 Topics: Acetazolamide; Ascites; Chlorothiazide; Diuretics; Humans; Liver Cirrhosis; Liver Function Tests; Or	1963
THE USE OF SPIRONOLACTONE AND LARGE DOSES OF STEROIDS IN THE TREATMENT OF ASCITES OF LIVER DISEASE. Southern medical journal, 1963, Volume: 56 Topics: Adrenal Cortex Hormones; Ascites; Chlorothiazide; Diuresis; Hepatic Encephalopathy; Humans; Hyponatr	1963
[TREATMENT OF ASCITES IN HEPATIC CIRRHOSIS. 2]. Prensa medica argentina, 1963, Jun-21, Volume: 50 Topics: Ascites; Dexamethasone; Diet, Sodium-Restricted; Hydrochlorothiazide; Liver Cirrhosis; Prognosis; Sp	1963
[OUR EXPERIENCE WITH SPIROLACTONE IN THE TREATMENT OF DECOMPENSATED CIRRHOSIS]. Gazette medicale de France, 1963, Nov-10, Volume: 70 Topics: Alcoholism; Ascites; Liver Cirrhosis; Spironolactone	1963
[INDICATIONS FOR SPIROLACTONE IN ASCITIC CIRRHOSIS]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Alcoholism; Ascites; Chlorothiazide; Liver Cirrhosis; Prednisone; Spironolactone	1963
[THERAPEUTIC INCIDENCES IN ASCITIC NUTRITIONAL CIRRHOSIS WITH JAUNDICE]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Adrenal Cortex Hormones; Alcoholism; Anti-Bacterial Agents; Ascites; Chlorothiazide; Diagnosis, Diff	1963
[OUR EXPERIENCE IN THE TREATMENT OF ASCITIC CIRRHOSIS WITH DIURETICS]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Ascites; Chlortetracycline; Diuretics; Humans; Liver Cirrhosis; Prednisone; Spironolactone	1963
[LIMITS OF TREATMENT OF CIRRHOSIS WITH DIURETICS (SALDIURETICS AND ALDOSTERONE ANTAGONISTS)]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Ascites; Diuretics; Humans; Hyperkalemia; Hyponatremia; Liver Cirrhosis; Mineralocorticoid Receptor	1963
[EFFECTS OF DIURETICS ON CARDIAC OUTPUT IN LIVER CIRRHOSIS]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Ascites; Cardiac Output; Chlorothiazide; Diuretics; Heart Function Tests; Humans; Liver Cirrhosis; S	1963
[WATER RETENTION IN CIRRHOTICS. PHYSIOPATHOLOGICAL DATA AND THERAPEUTIC RESULTS]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Ascites; Edema; Heart Failure; Humans; Hypokalemia; Hyponatremia; Liver Cirrhosis; Mineralocorticoid	1963
[TREATMENT OF LIVER CIRRHOSIS ACCOMPANIED BY ASCITES AND EDEMA]. Ugeskrift for laeger, 1963, Nov-22, Volume: 125 Topics: Anticoagulants; Ascites; Diet, Sodium-Restricted; Diuretics; Edema; Humans; Hydroflumethiazide; Live	1963
[INDICATIONS FOR THE TREATMENT OF ASCITIC CIRRHOSIS ACCORDING TO ITS CLINICAL FORMS]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1963, Nov-29, Volume: 114 Topics: Alcoholism; Ascites; Benzothiadiazines; Diet, Reducing; Diet, Sodium-Restricted; Diuretics; Liver Ci	1963
[CLINICAL REMARKS ON THE TREATMENT OF THE ASCITES OF CIRRHOTICS BY SPIRONOLACTONE]. La Presse medicale, 1963, Dec-14, Volume: 71 Topics: Ascites; Humans; Liver Cirrhosis; Spironolactone	1963
[RESULTS ACHIEVED WITH PROGESTERONE AND ALDACTONE IN PATIENTS WITH EDEMA AND ASCITES REFRACTORY TO MERCURIAL AND ORAL DIURETICS OF THE SULFONAMIDE GROUP]. Turk Tip Cemiyeti mecmuasi, 1963, Volume: 29 Topics: Ascites; Chlorothiazide; Diuretics; Edema; Humans; Organomercury Compounds; Progesterone; Spironolac	1963
[CLINICAL RESEARCH ON A NEW DIURETIC: TRIAMTERENE]. Minerva medica, 1963, Oct-20, Volume: 54 Topics: Ascites; Diabetes Insipidus; Diuretics; Edema; Humans; Hydrochlorothiazide; Hyperaldosteronism; Live	1963
[HOW TO TREAT CIRRHOTIC ASCITES IN 1963]. Revue medicale de Liege, 1963, Dec-15, Volume: 18 Topics: Ascites; Benzothiadiazines; Diet, Sodium-Restricted; Drainage; Humans; Liver Cirrhosis; Mannitol; Mi	1963
"REFRACTORY" ASCITES OF CIRRHOSIS: NEWER THERAPEUTIC PROCEDURES. Connecticut medicine, 1964, Volume: 28 Topics: Ascites; Bendroflumethiazide; Humans; Hydrochlorothiazide; Liver Cirrhosis; Prednisone; Spironolacto	1964
[RESULTS OF EXPERIMENTATION WITH A MICRONIZED ALDACTONE (8013 MCB) AND SULFONAMIDE DIURETIC (8093 CB) COMBINATION IN THE TREATMENT OF EDEMA]. Annales medicales de Nancy, 1963, Volume: 2 Topics: Ascites; Benzothiadiazines; Diuretics; Edema; Heart Failure; Humans; Liver Cirrhosis; Spironolactone	1963
[THE ALDOSTERONE ANTAGONISTS IN THE TREATMENT OF CIRRHOTIC ASCITIS]. Revista espanola de las enfermedades del aparato digestivo y de la nutricion, 1963, Volume: 22 Topics: Adrenal Cortex Hormones; Ascites; Diuresis; Hernia, Umbilical; Humans; Hyperaldosteronism; Liver Cir	1963
[CONTRIBUTION TO THE STUDY OF THE ACTION OF TRIAMTERENE IN THE TREATMENT OF ALCOHOLIC CIRRHOSIS WITH ASCITES. (APROPOS OF 24 CASES)]. Journal de medecine de Lyon, 1964, Jan-20, Volume: 45 Topics: Ascites; Body Fluids; Diuretics; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Potassium; Pterins; Sp	1964
[TRIAL OF TRIAMTERENE IN THE TREATMENT OF CIRRHOTIC AND NEOPLASTIC EDEMA. APROPOS OF 58 CASES]. Journal de medecine de Lyon, 1964, Jan-20, Volume: 45 Topics: Abdominal Neoplasms; Ascites; Benzothiadiazines; Body Fluids; Diuretics; Edema; Liver Cirrhosis; Pot	1964
[NATRIURETIC DRUGS]. Revista medica de Chile, 1963, Volume: 91 Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Di	1963
[ASSOCIATION OF INTRAVENOUS ALBUMIN WITH DIURETICS IN SEVERE ASCITIC CIRRHOSIS]. Schweizerische medizinische Wochenschrift, 1964, Feb-22, Volume: 94 Topics: Albumins; Ascites; Diuretics; Humans; Infusions, Parenteral; Liver Cirrhosis; Serum Albumin; Spirono	1964
[ON THE DIURETIC EFFECT OF THE ADRENOSTATIC DRUG METHOPYRAPONE]. Deutsche medizinische Wochenschrift (1946), 1964, Jun-05, Volume: 89 Topics: Ascites; Dexamethasone; Diuretics; Edema; Heart Failure; Ketones; Liver Cirrhosis; Metyrapone; Miner	1964
[ON THE DIURETIC EFFECT OF THE ADRENOSTATIC DRUG METHOPYRAPONE]. Deutsche medizinische Wochenschrift (1946), 1964, Jun-12, Volume: 89 Topics: Ascites; Dexamethasone; Diuretics; Edema; Heart Failure; Ketones; Liver Cirrhosis; Metyrapone; Miner	1964
[PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF SECONDARY ALDOSTERONISM AND ITS TREATMENT]. Folia clinica internacional, 1964, Volume: 14 Topics: Adrenocorticotropic Hormone; Aldosterone; Ascites; Body Fluids; Classification; Dexamethasone; Extra	1964
[THE CURRENT TREATMENT OF CIRRHOTIC ASCITES]. La Presse medicale, 1964, Jun-13, Volume: 72 Topics: Adrenal Cortex Hormones; Ascites; Diet; Diet Therapy; Diuretics; Drainage; Humans; Liver Cirrhosis;	1964
CIRRHOSIS--FLUID RETENTION AND ASCITES. Modern treatment, 1964, Volume: 1 Topics: Ascites; Chlorothiazide; Diet; Diet Therapy; Diuretics; Edema; Humans; Hypertension; Hypertension, P	1964
[OBSERVATIONS ON THE CLINICAL USE OF TRIAMTERENE IN TREATMENT OF THE ASCITES OF HEPATIC CIRRHOSIS]. La Clinica terapeutica, 1964, Jun-15, Volume: 29 Topics: Ascites; Diuretics; Humans; Hydrochlorothiazide; Liver Cirrhosis; Pterins; Spironolactone; Triamtere	1964
[AUTOPERFUSION OF ASCITIC FLUID AND DIURETIC TREATMENT IN PREPARATION FOR SURGERY IN CIRRHOTIC PATIENTS]. Minerva medica, 1964, Jun-13, Volume: 55 Topics: Ascites; Ascitic Fluid; Diet, Sodium-Restricted; Diuretics; Humans; Hydrochlorothiazide; Liver Cirrh	1964
[ON THE SUBJECT OF DIURESIS WITH METOPIRONE (SU-4885)]. Minerva medica, 1964, Jul-28, Volume: 55 Topics: Acetazolamide; Ascites; Chlorthalidone; Diuresis; Diuretics; Humans; Ketones; Liver Cirrhosis; Metyr	1964
A CLINICAL COMPARISON OF CHLOROTHIAZIDE AND MDI 193 IN PATITENTS WITH HEPATIC CIRRHOSIS AND CONTROLLED ASCITES. Lancet (London, England), 1964, Jun-20, Volume: 1, Issue:7347 Topics: Ascites; Benzothiadiazines; Biomedical Research; Chlorothiazide; Diuretics; Liver Cirrhosis; Spirono	1964
[ON MODIFICATIONS OF PLASMA AND URINARY ELECTROLYTES IN ASCITOGENIC HEPATIC CIRRHOSIS IN TREATMENT WITH TRIAMTERENE ALONE AND ASSOCIATED WITH HYDROCHLOROTHIAZIDE AND WITH SPIRONOLACTONE]. Minerva medica, 1964, Sep-15, Volume: 55 Topics: Ascites; Biomedical Research; Chlorides; Electrolytes; Geriatrics; Humans; Hydrochlorothiazide; Live	1964
[DIURETIC THERAPY OF THE ASCITIC FORM OF LIVER CIRRHOSIS WITH ANGIOTENSIN II AND THE MECHANISM OF ITS ACTION]. Sbornik lekarsky, 1964, Volume: 66 Topics: Angiotensin II; Angiotensins; Ascites; Diuresis; Diuretics; Drug Therapy; Humans; Kidney Glomerulus;	1964
INTRACTABLE ASCITES. The American journal of gastroenterology, 1964, Volume: 42 Topics: Adrenal Cortex Hormones; Albumins; Ascites; Diet, Sodium-Restricted; Diuretics; Hyperaldosteronism;	1964
FETAL ASCITES--LIVER GIANT-CELL TRANSFORMATION. REPORT OF A CASE WITH RECOVERY. American journal of diseases of children (1960), 1964, Volume: 108 Topics: Ascites; Biopsy; Drainage; Exchange Transfusion, Whole Blood; Fetal Diseases; Humans; Hydrochlorothi	1964
[STUDY OF THE ASSOCIATION OF A SALT DIURETIC AND A SPIRONOLACTONE. APROPOS OF 50 OBSERVATIONS]. Lyon medical, 1964, Nov-22, Volume: 212 Topics: Abdominal Neoplasms; Ascites; Benzothiadiazines; Biomedical Research; Diuretics; Edema; Heart Diseas	1964
METABOLIC STUDIES WITH THE DIURETIC TRIAMTERENE IN PATIENTS WITH CIRRHOSIS AND ASCITES. The New England journal of medicine, 1964, Dec-10, Volume: 271 Topics: Ammonia; Ascites; Blood; Carbon Dioxide; Chlorides; Creatine; Creatinine; Diuresis; Diuretics; Drug	1964
Hyperaldo-steronism in liver disease. The treatment of refractory ascites by adrenalectomy and by the administration of spirolactones. Gastroenterology, 1960, Volume: 38 Topics: Adrenalectomy; Aldosterone; Ascites; Humans; Lactones; Liver Diseases; Spironolactone	1960
Resistant ascites treated by combined diuretic therapy (spironolactone, mannitol, and chlorothiazide). Lancet (London, England), 1960, Mar-19, Volume: 1, Issue:7125 Topics: Aldosterone; Ascites; Chlorothiazide; Diuretics; Mannitol; Mineralocorticoid Receptor Antagonists; S	1960
[Treatment of the ascites and edema of cirrhotics by spironolactone]. Algerie medicale, 1962, Volume: 66 Topics: Aldosterone; Ascites; Diuretics; Edema; Edetic Acid; Mineralocorticoid Receptor Antagonists; Spirono	1962
[Spirolactone treatment of liver cirrhosis with edema and ascites]. Nordisk medicin, 1962, Jan-04, Volume: 67 Topics: Aldosterone; Ascites; Edema; Edetic Acid; Liver Cirrhosis; Mineralocorticoid Receptor Antagonists; O	1962
[On the therapy of edemas caused by liver disease. Changes of water-salt metabolism and of the urinary corticosteroid picture in cirrhotics treated with prednisone, spirolactone and methopyrone]. Minerva medica, 1961, Dec-26, Volume: 52 Topics: Adrenal Cortex Hormones; Ascites; Edema; Humans; Liver Cirrhosis; Liver Diseases; Prednisone; Spiron	1961
Budd-Chiari syndrome in a young patient with celiac sprue: a case report. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2003, Volume: 14, Issue:4 Topics: Ascites; Budd-Chiari Syndrome; Celiac Disease; Diet, Gluten-Free; Diuretics; Duodenum; Endoscopy, Di	2003
[Portopulmonary hypertension due to schistosomiasis in two Malagasy patients]. Bulletin de la Societe de pathologie exotique (1990), 2007, Volume: 100, Issue:1 Topics: Adolescent; Adult; Anthelmintics; Ascites; Combined Modality Therapy; Diet, Sodium-Restricted; Dyspn	2007
Eplerenone relieves spironolactone-induced painful gynaecomastia in patients with decompensated hepatitis B-related cirrhosis. Scandinavian journal of gastroenterology, 2007, Volume: 42, Issue:12 Topics: Ascites; Eplerenone; Gynecomastia; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Mineralocorticoid	2007
Combination of clonidine and diuretic in cirrhotic ascites with activated sympathetic nervous system: Would it be a magical bullet? Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:1 Topics: Ascites; Clonidine; Diuretics; Humans; Liver Cirrhosis; Spironolactone; Sympathetic Nervous System;	2008
[Management of ascites in the cirrhotic patient using a 6-chloro-pyrazinamine derivative. I. Metabolic studies]. Gaceta medica de Mexico, 1966, Volume: 96, Issue:12 Topics: Ascites; Diuresis; Ethacrynic Acid; Humans; Liver Cirrhosis; Pyrazinamide; Spironolactone	1966
[Saluretics in liver diseases]. Munchener medizinische Wochenschrift (1950), 1966, Dec-23, Volume: 108, Issue:51 Topics: Ammonium Chloride; Ascites; Capillary Permeability; Diuretics; Humans; Hypertension, Portal; Hypopro	1966
Diuretics. The New England journal of medicine, 1967, Apr-27, Volume: 276, Issue:17 Topics: Aldosterone; Ascites; Chlorothiazide; Diuretics; Edema; Ethacrynic Acid; Furosemide; Humans; Organom	1967
Comparison of oral isosorbide and intravenous mannitol as adjuncts to the diuresis of patients with cirrhosis of the liver. The American journal of the medical sciences, 1967, Volume: 254, Issue:3 Topics: Adult; Ascites; Humans; Hydrochlorothiazide; Injections, Intravenous; Isosorbide Dinitrate; Liver Ci	1967
[Therapy of ascites by peritoneo-venous shunt]. Deutsche medizinische Wochenschrift (1946), 1984, Jun-15, Volume: 109, Issue:24 Topics: Ascites; Diet, Sodium-Restricted; Equipment Failure; Furosemide; Hemorrhage; Humans; Life Expectancy	1984
[Disorders of water and electrolyte equilibrium in liver diseases. Part 3: therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1982, May-14, Volume: 124, Issue:19 Topics: Ascites; Benzothiadiazines; Canrenoic Acid; Diuretics; Humans; Hyperaldosteronism; Liver Diseases; S	1982
Control of malignant ascites with spironolactone. The British journal of surgery, 1982, Volume: 69, Issue:8 Topics: Abdominal Neoplasms; Aldosterone; Ascites; Breast Neoplasms; Female; Humans; Male; Renin; Sodium; Sp	1982
[Study on the effect and tolerance of Acelate as an aldosterone antagonist]. Die Medizinische Welt, 1982, Jun-04, Volume: 33, Issue:22 Topics: Ascites; Edema; Female; Heart Diseases; Humans; Hypertension; Male; Middle Aged; Spironolactone	1982
[Physiopathology and therapy of the ascites in liver cirrhosis]. Giornale di clinica medica, 1982, Volume: 63, Issue:10 Topics: Aldosterone; Ascites; Diet, Sodium-Restricted; Humans; Kidney Failure, Chronic; Liver Cirrhosis; Sod	1982
Hyperaldosteronism associated with liver metastases. JAMA, 1980, Jul-11, Volume: 244, Issue:2 Topics: Aldosterone; Alkaline Phosphatase; Ascites; Bilirubin; Edema; Female; Humans; Hyperaldosteronism; Li	1980
Use of piretanide, a new loop diuretic, in cirrhosis with ascites: relationship between the diuretic response and the plasma aldosterone level. Gut, 1980, Volume: 21, Issue:10 Topics: Adult; Aged; Aldosterone; Ascites; Diuretics; Drug Therapy, Combination; Female; Humans; Liver Cirrh	1980
[Pharmacodynamic and pharmacokinetic studies of muzolimine in patients with hepatogeneous ascites (author's transl)]. Zeitschrift fur Gastroenterologie, 1980, Volume: 18, Issue:10 Topics: Ascites; Chlorides; Female; Half-Life; Humans; Male; Muzolimine; Potassium; Pyrazoles; Sodium; Spiro	1980
Drug therapy of ascites. American family physician, 1981, Volume: 23, Issue:1 Topics: Ascites; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hydrochlorothiazide; Sodium Chloride Sympor	1981
Spontaneous bacterial peritonitis caused by Citrobacter diversus: case report. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1997, Volume: 24, Issue:1 Topics: Aged; Alcohol Drinking; Ascites; Cefotaxime; Cephalosporins; Citrobacter; Diagnosis, Differential; D	1997
[Treatment of refractory ascites with clonidine and spironolactone]. Gastroenterologie clinique et biologique, 1997, Volume: 21, Issue:6-7 Topics: Adrenergic alpha-Agonists; Adult; Aged; Ascites; Clonidine; Drug Therapy, Combination; Female; Human	1997
Predictive factors influencing the therapeutic response to diuretic treatment of ascites in nonazotemic cirrhotic patients. Scandinavian journal of gastroenterology, 1998, Volume: 33, Issue:4 Topics: Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis, Alcoholi	1998
[Biological factors influencing response to diuretics in patients with cirrhosis and ascites]. Gastroenterologie clinique et biologique, 2001, Volume: 25, Issue:3 Topics: Aldosterone; Ascites; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Humans; Hyperkalemi	2001
[Therapeutic program for ascites. Recommendations from the Swedish Society of Gastroenterology and Gastrointestinal Endoscopy]. Lakartidningen, 2001, Dec-05, Volume: 98, Issue:49 Topics: Ascites; Contraindications; Diuretics; Furosemide; Humans; Liver Cirrhosis; Paracentesis; Peritoneov	2001
Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. The American journal of digestive diseases, 1978, Volume: 23, Issue:11 Topics: Adult; Ascites; Blood Urea Nitrogen; Creatinine; Drug Evaluation; Female; Hepatitis, Alcoholic; Huma	1978
Gastric ulceration induced by spironolactone. Lancet (London, England), 1977, Feb-26, Volume: 1, Issue:8009 Topics: Ascites; Female; Hematemesis; Humans; Middle Aged; Peptic Ulcer Hemorrhage; Spironolactone; Stomach	1977
Spironolactone and metabolic acidosis. Annals of internal medicine, 1979, Volume: 91, Issue:2 Topics: Acidosis; Aged; Ascites; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Spironolactone	1979
[Plasma aldosterone and electrolytes in primary and secondard aldosteronism (author's transl)]. Medizinische Klinik, 1979, Sep-14, Volume: 74, Issue:37 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aldosterone; Ascites; Electrolytes; Female; Humans; Hypera	1979
[Controlled clinical study of the effect of combined administration of ethacrynic acid and spironolactone in ascitic liver cirrhosis]. La Clinica terapeutica, 1979, Jul-31, Volume: 90, Issue:2 Topics: Ascites; Drug Evaluation; Drug Synergism; Ethacrynic Acid; Humans; Liver Cirrhosis; Spironolactone	1979
Management of hepatic ascites. British medical journal, 1978, Jan-14, Volume: 1, Issue:6105 Topics: Ascites; Diuresis; Drainage; Humans; Hypokalemia; Liver Diseases; Spironolactone	1978
Fatal hyperkalemia and hyperchloremic acidosis. Association with spironolactone in the absence of renal impairment. JAMA, 1978, Sep-29, Volume: 240, Issue:14 Topics: Acidosis; Ascites; Chlorine; Humans; Hyperkalemia; Male; Middle Aged; Mineralocorticoid Receptor Ant	1978
[Aldosterone and renin in liver cirrhosis with ascites]. Schweizerische medizinische Wochenschrift, 1977, Dec-03, Volume: 107, Issue:48 Topics: Aldosterone; Ascites; Furosemide; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Renin; Spiron	1977
Opposite effects of spironolactone and amiloride on potassium excretion in a patient with ascites due to liver cirrhosis. Endokrinologie, 1976, Volume: 67, Issue:3 Topics: Amiloride; Ascites; Drug Interactions; Female; Humans; Liver Cirrhosis; Middle Aged; Potassium; Pyra	1976
Reversal of the suppressed potassium excretion during treatment with combinations of antikaliuretic drugs (spironolactone, canrenone, triamterene, amiloride) in patients with liver cirrhosis. International journal of clinical pharmacology and biopharmacy, 1976, Volume: 14, Issue:3 Topics: Amiloride; Ascites; Canrenone; Diuresis; Diuretics; Drug Synergism; Drug Therapy, Combination; Human	1976
[Ovarian hyperstimulation syndrome. Notes on the physiopathology and treatment apropos of 3 cases]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1975, Volume: 4, Issue:2 Topics: Adult; Ascites; Capillary Permeability; Chorionic Gonadotropin; Female; Gonadotropins, Pituitary; Hu	1975
Diuresis increases ascitic fluid opsonic activity in patients who survive spontaneous bacterial peritonitis. Journal of hepatology, 1992, Volume: 14, Issue:2-3 Topics: Amiloride; Ascites; Bacterial Infections; Complement C3; Complement C4; Diuresis; Humans; Liver Cirr	1992
Spironolactone pharmacokinetics and pharmacodynamics in patients with cirrhotic ascites. Gastroenterology, 1992, Volume: 102, Issue:5 Topics: Adult; Aged; Ascites; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Sodium; Spironolactone	1992
A pathophysiological interpretation of unresponsiveness to spironolactone in a stepped-care approach to the diuretic treatment of ascites in nonazotemic cirrhotic patients. Hepatology (Baltimore, Md.), 1991, Volume: 14, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Ascites; Diuretics; Drug Resistance; Electrolytes; Fema	1991
Spironolactone and canrenoate: different antialdosteronic diuretic agents. Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:5 Topics: Ascites; Canrenoic Acid; Canrenone; Humans; Liver Cirrhosis; Recurrence; Spironolactone	1991
[Effect of captopril therapy on sodium and water excretion in patients with liver cirrhosis and ascites]. Klinische Wochenschrift, 1989, Aug-01, Volume: 67, Issue:15 Topics: Adult; Aged; Ascites; Blood Pressure; Captopril; Diuresis; Diuretics; Dose-Response Relationship, Dr	1989
Ascites in cirrhosis: pathophysiology and management. British journal of hospital medicine, 1988, Volume: 40, Issue:4 Topics: Ascites; Diagnosis, Differential; Humans; Inhalation; Liver Cirrhosis; Peritonitis; Spironolactone;	1988
[Has treatment of ascites changed?]. Zeitschrift fur Gastroenterologie, 1988, Volume: 26, Issue:5 Topics: Ascites; Drainage; Drug Therapy, Combination; Furosemide; Humans; Spironolactone	1988
Effect of spironolactone on renal prostaglandin excretion in patients with liver cirrhosis and ascites. Journal of hepatology, 1986, Volume: 3, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Aged, 80 and over; Ascites; Body Weight; Dinoprostone; Fe	1986
Refractory ascites: definition and mechanism. Minerva medica, 1987, May-31, Volume: 78, Issue:10 Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascites; Diet, Sodium-Restricted; Diuretics; Drainage; Drug	1987
Rapid diuresis in patients with ascites from chronic liver disease: the importance of peripheral edema. Gastroenterology, 1986, Volume: 90, Issue:6 Topics: Amiloride; Ascites; Body Weight; Chronic Disease; Diuresis; Edema; Electrolytes; Furosemide; Humans;	1986
[Therapy of ascites in the cirrhosis patient]. La Clinica terapeutica, 1986, May-31, Volume: 117, Issue:4 Topics: Albumins; Ascites; Diet, Sodium-Restricted; Diuretics; Follow-Up Studies; Humans; Liver Cirrhosis; P	1986
Ascites in cirrhosis. Annals of internal medicine, 1987, Volume: 106, Issue:1 Topics: Ascites; Humans; Liver Cirrhosis; Spironolactone	1987
Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. Nephron, 1986, Volume: 44, Issue:4 Topics: Adult; Ascites; Body Weight; Creatinine; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypon	1986
Amiloride ('MK 870') in patients with ascites due to cirrhosis of the liver. Lancet (London, England), 1968, Jan-20, Volume: 1, Issue:7534 Topics: Adult; Ascites; Bicarbonates; Creatinine; Diuretics; Ethacrynic Acid; Furosemide; Guanidines; Humans	1968
Measurement of rectal electrical potential difference as an instant screening-test for hyperaldosteronism. Lancet (London, England), 1970, Sep-26, Volume: 2, Issue:7674 Topics: Adenoma; Adrenal Gland Neoplasms; Ascites; Electrodes; Electrodiagnosis; Feces; Fludrocortisone; Hum	1970
[Disorders of water-electrolyte metabolism associated with decompensated cirrhosis. The danger of various therapeutic drugs]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, May-14, Volume: 44, Issue:23 Topics: Acute Kidney Injury; Adult; Aged; Ascites; Blood Transfusion; Blood Urea Nitrogen; Blood Volume Dete	1968
[Treatment of resistant ascites in cirrhotic patients]. L'union medicale du Canada, 1974, Volume: 103, Issue:12 Topics: Aged; Ascites; Body Weight; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Potassium; Sodium; S	1974
The effect of spironolactone and canrenone on the digoxin radioimmunoassay. Research communications in chemical pathology and pharmacology, 1974, Volume: 9, Issue:4 Topics: Animals; Antigen-Antibody Complex; Ascites; Charcoal; Digoxin; Half-Life; Humans; Immune Sera; Ketos	1974
[Budd-Chiari syndrome after taking contraceptive drugs]. Deutsche medizinische Wochenschrift (1946), 1972, Nov-03, Volume: 97, Issue:44 Topics: Adult; Ascites; Budd-Chiari Syndrome; Contraceptives, Oral; Coumarins; Ethinyl Estradiol; Female; He	1972
Hypoproteinemia, splenomegaly, ascites and disseminated histoplasmosis. The American journal of medicine, 1973, Volume: 54, Issue:1 Topics: Amphotericin B; Ascites; Furosemide; Histoplasmosis; Hodgkin Disease; Humans; Hypoproteinemia; Male;	1973
[Use of F. X. Bsteh's ascite button filter]. Zentralblatt fur Chirurgie, 1973, Jan-12, Volume: 98, Issue:2 Topics: Ascites; Diuretics; Humans; Male; Methods; Spironolactone; Surgical Instruments	1973
[Pregnancy in liver cirrhosis. Internal medicine and gynecological aspects]. Medizinische Klinik, 1973, Apr-20, Volume: 68, Issue:16 Topics: Adult; Ascites; Colon; Diet, Sodium-Restricted; Diuretics; Esophageal and Gastric Varices; Esophagea	1973
Letter: Ascites and oedema in liver disease. British medical journal, 1973, Oct-27, Volume: 4, Issue:5886 Topics: Ascites; Edema; Humans; Kidney; Liver Diseases; Spironolactone	1973
[Diuretic treatment of hepatic cirrhosis: use of distal diuretics]. Revista clinica espanola, 1974, Jan-15, Volume: 132, Issue:1 Topics: Administration, Oral; Ascites; Drug Evaluation; Humans; Liver Cirrhosis; Spironolactone	1974
[Pathogenesis and therapy of ascites in liver cirrhosis]. Der Internist, 1966, Volume: 7, Issue:1 Topics: Acid-Base Equilibrium; Alkalosis; Ascites; Deficiency Diseases; Diet; Diuresis; Diuretics; Furosemid	1966
Hyperkalemic intermittent paralysis associated with spironolactone in a patient with cardiac cirrhosis. American heart journal, 1968, Volume: 76, Issue:3 Topics: Acetazolamide; Adult; Aldosterone; Ascites; Female; Furosemide; Heart Failure; Heart Valve Diseases;	1968
High doses of spironolactone in the treatment of liver cirrhosis with ascites. The British journal of clinical practice, 1972, Volume: 26, Issue:1 Topics: Adult; Aged; Ascites; Furosemide; Humans; Liver Cirrhosis; Male; Middle Aged; Prednisolone; Spironol	1972
[Joint study on the effectiveness of diuretic measures in hydropic diseases. IV. Statistical analysis of the relationship of the data collected]. Klinische Wochenschrift, 1971, Sep-15, Volume: 49, Issue:18 Topics: Ascites; Biometry; Body Weight; Diet Therapy; Diuresis; Diuretics; Edema; Factor Analysis, Statistic	1971
Use of metolazone in the treatment of ascites due to liver disease. British medical journal, 1971, Oct-30, Volume: 4, Issue:5782 Topics: Adult; Ascites; Chlorides; Chronic Disease; Diuretics; Female; Hepatic Encephalopathy; Humans; Hypok	1971
The complications of diuretic therapy in patients with cirrhosis. Annals of the New York Academy of Sciences, 1966, Nov-22, Volume: 139, Issue:2 Topics: Alkalosis; Ascites; Blood Urea Nitrogen; Chlorothiazide; Ethacrynic Acid; Furosemide; Hepatic Enceph	1966
Medical grand rounds from the University of Alabama Medical Center. Southern medical journal, 1969, Volume: 62, Issue:3 Topics: Alcoholism; Antacids; Ascites; Biopsy; Blood Transfusion; Collateral Circulation; Esophageal and Gas	1969
[Current treatment of the edematous ascitic syndrome in alcoholic liver cirrhosis]. Journal de medecine de Lyon, 1969, Dec-20, Volume: 50, Issue:177 Topics: Adrenal Cortex Hormones; Alcoholism; Ascites; Diet Therapy; Diuretics; Edema; Humans; Liver Cirrhosi	1969
Spironolactone diuresis in patients with cirrhosis and ascites. British medical journal, 1970, Nov-14, Volume: 4, Issue:5732 Topics: Alcoholism; Aldosterone; Ascites; Humans; Liver Cirrhosis; Potassium; Sodium; Spironolactone	1970
[Effect of aldactone on potassium storage in patients with ascitic cirrhosis]. Annales de medecine interne, 1970, Volume: 121, Issue:2 Topics: Adult; Ascites; Diuresis; Humans; Liver Cirrhosis; Male; Middle Aged; Potassium; Sodium; Spironolact	1970
The effect of spironolactone on sodium transport in the absence of aldosterone. Clinical science, 1970, Volume: 39, Issue:6 Topics: Aldosterone; Animals; Ascites; Biological Transport; Carcinoma; Depression, Chemical; Erythrocytes;	1970
[Ascites in pregnancy in liver cirrhosis]. Zeitschrift fur Geburtshilfe und Gynakologie, 1970, Volume: 172, Issue:2 Topics: Ascites; Diet, Sodium-Restricted; Female; Fetal Death; Humans; Hypertension, Portal; Infant, Newborn	1970
[Clinical study of the use of "Spirolang" 50]. Minerva medica, 1971, Feb-28, Volume: 62, Issue:17 Topics: Adult; Aged; Ascites; Chronic Disease; Digitalis Glycosides; Diuresis; Electrolytes; Ethacrynic Acid	1971
[Treatment of cirrhotic edemas with triamterene, amiloride and spirolactone. New clinical and biological facts]. Schweizerische medizinische Wochenschrift, 1971, Mar-20, Volume: 101, Issue:11 Topics: Adult; Alcoholism; Ascites; Diuretics; Edema; Female; Humans; Liver Cirrhosis; Middle Aged; Natriure	1971
[Anti-aldosterone therapy in cirrhosis of the liver with ascites]. Sovetskaia meditsina, 1967, Volume: 30, Issue:2 Topics: Ascites; Humans; Hyperaldosteronism; Liver Cirrhosis; Spironolactone	1967
[Contribution to the study of the treatment of the ascitic syndrome of cirrhosis by the combination of spironolactone and sulfonamide diuretic. Initial therapy and supportive therapy. Apropos of 55 cases]. Journal de medecine de Lyon, 1967, Feb-05, Volume: 48, Issue:114 Topics: Adult; Aged; Alcoholism; Ascites; Benzothiadiazines; Diuretics; Female; Humans; Liver Cirrhosis; Mal	1967
Amiloride. A potassium-sparing natriuretic agent. Circulation, 1968, Volume: 37, Issue:1 Topics: Acetazolamide; Aldosterone; Ammonia; Ascites; Bicarbonates; Blood Pressure; Chlorides; Chlorothiazid	1968
Hyperkalemic changes during spironolactone therapy for cirrhosis and ascites, with special reference to hyperkalemic intermittent paralysis. Journal of the American Geriatrics Society, 1968, Volume: 16, Issue:8 Topics: Ascites; Diuretics; Female; Humans; Hyperkalemia; Kidney Function Tests; Kidney Tubules; Liver Cirrh	1968
[Use of Aldactone in a patient with ascitic form of liver cirrhosis]. Pediatriia akusherstvo i ginekologiia, 1968, Volume: 3 Topics: Adolescent; Ascites; Humans; Liver Cirrhosis; Male; Spironolactone	1968
[Clinical and biochemical study of the therapeutic effect of the diuretic triamterene in ascitogenic cirrhosis]. Medicina interna, 1968, Volume: 20, Issue:5 Topics: Adrenal Cortex Hormones; Ascites; Diuresis; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhos	1968
[Influence of diuretics on the survival of 180 patients with cirrhosis of the liver and ascites]. Schweizerische medizinische Wochenschrift, 1969, Feb-08, Volume: 99, Issue:6 Topics: Adult; Aged; Alcoholism; Ascites; Chlorothiazide; Chlorthalidone; Diuretics; Ethacrynic Acid; Humans	1969
The impact of diuretics on chronic liver disease. The American journal of gastroenterology, 1969, Volume: 52, Issue:1 Topics: Alcoholism; Ascites; Chlorothiazide; Diet Therapy; Diuretics; Ethacrynic Acid; Furosemide; Humans; L	1969
[Portal hypertension in chronic liver diseases and its therapy]. Medizinische Monatsschrift, 1969, Volume: 23, Issue:2 Topics: Ascites; Chronic Disease; Esophageal and Gastric Varices; Humans; Hypertension, Portal; Liver Cirrho	1969
Clinical experience with Dytac. Minerva medica, 1963, Oct-10, Volume: 54, Issue:81 Suppl Topics: Ascites; Bendroflumethiazide; Edema; Humans; Natriuresis; Spironolactone; Triamterene	1963
[Effects of triamterene in combination with other diuretics in liver cirrhosis]. Minerva medica, 1963, Oct-10, Volume: 54, Issue:81 Suppl Topics: Ascites; Bendroflumethiazide; Chlorothiazide; Humans; Hydrochlorothiazide; Liver Cirrhosis; Spironol	1963
[Value of the association of a certain dose of spironolactone with a sulfamide diuretic in the treatment of ascitic cirrhosis]. Semaine therapeutique, 1964, Volume: 40, Issue:1 Topics: Adult; Aged; Ascites; Benzothiadiazines; Humans; Liver Cirrhosis; Middle Aged; Spironolactone; Sulfo	1964
[Prolonged treatment of ascitic cirrhosis by the combination of a saldiuretic and a spironolactone]. Lyon medical, 1966, Jan-02, Volume: 215, Issue:1 Topics: Aged; Ascites; Diuretics; Humans; Liver Cirrhosis; Male; Middle Aged; Spironolactone	1966
Renal failure with cirrhosis. Observations on the role of diuretics. Annals of internal medicine, 1966, Volume: 64, Issue:6 Topics: Acute Kidney Injury; Aminohippuric Acids; Ascites; Blood; Blood Volume; Creatine; Diuretics; Ethacry	1966
Medical management of ascites in hepatic cirrhosis. Chinese medical journal (Peking, China : 1932), 1966, Volume: 85, Issue:5 Topics: Adolescent; Adult; Aminophylline; Anabolic Agents; Ascites; China; Diet, Sodium-Restricted; Female;	1966
Newer diuretics in the treatment of cardiac or hepatic disease in elderly patients. Journal of the American Geriatrics Society, 1966, Volume: 14, Issue:12 Topics: Ascites; Benzothiadiazines; Blood Glucose; Blood Urea Nitrogen; Body Weight; Cardiovascular Diseases	1966
[The combination of corticoids, spironolactone, salidiuretics and mannitol according to a particular schema of treatment of ascitic cirrhosis]. Schweizerische medizinische Wochenschrift, 1966, May-21, Volume: 96, Issue:20 Topics: Adrenal Cortex Hormones; Ascites; Diuretics; Humans; Liver Cirrhosis; Mannitol; Spironolactone; Tria	1966
[Treatment of ascites in hepatic cirrhosis]. Revista espanola de las enfermedades del aparato digestivo, 1966, Volume: 25, Issue:9 Topics: Acetazolamide; Adult; Aged; Ascites; Benzothiadiazines; Furosemide; Humans; Liver Cirrhosis; Male; M	1966

spironolactone and Ascites

Research Excerpts

Research

Studies (223)

Authors

Clinical Trials (6)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Sehgal, R	1
Singh, H	1
Singh, IP	1
Miyazaki, M	1
Yada, M	1
Tanaka, K	1
Senjyu, T	1
Goya, T	1
Motomura, K	1
Kohjima, M	1
Kato, M	2
Masumoto, A	1
Kotoh, K	1
Iwasa, M	1
Ishihara, T	1
Isoai, A	1
Kobayashi, R	1
Torii, N	1
Soneda, N	1
Takei, Y	1
Zhu, YF	1
Gu, XB	1
Zhu, HY	1
Yang, XJ	1
Wang, D	1
Yu, P	1
Saffouri, GB	1
Wittich, CM	1
Perri, GA	1
Celtik, C	1
Durmaz, O	1
Oner, N	1
Yavuz, T	1
Gökce, S	1
Aydogan, A	1
Nisli, K	1
Emiroglu, HH	1
Ömeroglu, RE	1
Sökücü, S	1
Goto, A	1
Terai, S	1
Nakamura, M	1
Matsumoto, M	1
Sakaida, I	1
Minor, SE	1
Eliacin, I	1
Kashan, S	1
Whisenant, EB	1
Yakar, T	1
Demir, M	1
Dogan, O	1
Parlakgumus, A	1
Ozer, B	1
Serin, E	1
Kurosaki, M	1
Nakanishi, H	1
Izumi, N	1
Maier, KP	1
Hou, W	1
Sanyal, AJ	1
Ginès, P	7
Wong, F	3
Watson, H	2
Terg, R	1
Bruha, R	1
Zarski, JP	1
Dudley, F	1
Horsmans, Y	1
Angeli, P	2
Gow, P	1
Minini, P	1
Bernardi, M	2
Salerno, F	1
Cazzaniga, M	1
Accordino, S	1
Kalambokis, G	2
Tsianos, EV	2
Singhal, S	1
Baikati, KK	1
Jabbour, II	1
Anand, S	1
Kumar, M	1
Kamani, L	1
Hussain, R	1
Siddique, S	1
Santos, J	1
Planas, R	5
Pardo, A	2
Durández, R	1
Cabré, E	1
Morillas, RM	1
Granada, ML	1
Jiménez, JA	1
Quintero, E	3
Gassull, MA	1
KERR, DN	1
READ, AE	1
HASLAM, RM	1
SHERLOCK, S	5
DE FILIPPIS, V	1
MARSICO, F	1
PEDICINI, S	1
LEVRAT, M	1
BRETTE, R	2
FRANCOIS, B	1
TISSOT, A	1
MESTRALLET, G	2
LOCKWOOD, CH	1
VEITH, I	1
BONINI, A	1
van DOMMELEN, C	1
LE POOLE, A	1
VAANDRAGER, H	1
SCHOPMAN, W	1
WADMAN, SK	1
VELASCO, M	1
GAZMURI, R	1
KATZ, R	1
NEUMAYR, A	1
THUMB, N	1
TRETENHAHN, W	1
GANTT, CL	1
ECKLUND, RE	1
GARVOCK, WB	1
EZRIN, C	1
TAYLOR, R	1
GRAZIANI, G	1
MOLE, R	1
HSIEN, L	1
MIN-KUEI, T	1
CHIA-SHUN, C	1
CH'UNG-CHU, L	1
CHUN, Y	1
SHIH-YAO, L	1
FU-YUAN, F	1
SUNG-TS'E, L	1
RUNCAN, V	1
RACOVEANU, C	1
GEIB, R	1
POPESCU, T	1
STEIGMANN, F	4
SISON, A	1
DUBIN, A	3
TOH, CC	1
KHOO, OT	1
SHALDON, S	3
RYDER, JA	1
GARSENSTEIN, M	1
SALA, G	2
D'AMICO, G	1
RIVERA, A	1
SEPULVEDA, B	1
LANDA, L	2
CHAGOYA, L	1
HOWARD, MM	1
LEEVY, CM	1
BRUNNER, E	1
BALABANSKI, LT	1
ELMAHALLAWI, MN	1
SAYED, WA	1
EZZAT, E	1
CARPENTER, CJ	1
MITRA, P	1
SHAH, MJ	1
KHOKHANI, RC	1
VAIDYA, AB	1
SHETH, UK	1
STERNBERG, MS	1
HAGEDORN, CW	1
KALSER, MH	1
PEREZ, V	1
PICCALUGA, A	1
ALVAREZ, A	1
LEW, V	1
RATTI, J	1
GEFFROY, Y	1
DESHAYES, P	1
FABLET, J	1
CAYRON, G	1
CACHIN, M	1
LEVY, C	1
VARAY, A	1
BERTHELOT, J	1
BLONDON, J	1
BLERY, M	1
DUBRISAY, J	1
SCHNEIDER, JJ	1
BOIFFIN, A	1
MAHOUDEAU, D	1
ALBEAUX-FERNET, M	1
ROMANI, JD	1
EVEN, P	1
NICOLLO, F	1
BENHAMOU, JP	1
FAUVERT, R	1
CONTE, M	3
FOUET, P	1
JACOBS, C	1
DIGE-PETERSEN, H	1
DUPUY, R	1
VALLIN, J	1
BOUTELLIER, D	1
LODS, JC	1
MINICONI, P	2
BOURREILLE, J	2
CARAYON, P	2
ULAGAY, I	1
SEZER, R	1
D AMICO, G	1
VITERTARI, L	1
CASTELLUCCIO, A	1
POLLI, E	2
RUYTERS, L	1
ALVAREZ, S	1
TRIANTAFILIDES, T	1
KISSEL, P	1
DUREUX, JB	1
SCHMITT, J	1
GARCIA RAMOSARRIAGA, J	1
FRAISSE, H	2
ETAIX, JP	2
GIRARD, M	2
PLAUCHU, M	1
RONDELET, J	1
ARMASCRUZ, R	1
GOMEZ, R	1
MARDONES, J	1
PLAZADELOSREYES, M	1
VESIN, P	2
TRAVERSO, H	1
HIERHOLZER, K	2
HOFFMEISTER, W	1
VOLWILER, W	1
BORRELLI, PL	1
CAIRELLA, M	1
DEMARTIIS, M	1
LONGO, T	1
FORTI, D	1
CEREDA, UG	1
FRANZINI, P	1
MELLONI, GF	1
BARATTA, C	1
MARANGONI, R	1
MERLO, L	1
ANTOGNETTI, R	1
PAZOUREK, M	1
KUECHEL, O	1
HORKY, K	1
MILNER, LR	1
FLETCHER, CB	1
EAKIN, EL	1
ROTHMAN, PE	1
MOULINIER, B	1
TETE, R	1
COTTON, J	1
GINSBERG, DJ	1
SAAD, A	1
GABUZDA, GJ	1
HENLEY, KS	1
STREETEN, DH	1
POLLARD, HM	1
McLAREN, JR	1
SUDUCA, P	1
LAVOCAT, G	1
ISSAD, H	1
OFSTAD, J	1
SIGSTAD, H	1
PUPITA, F	1
DE MARTINIS, C	1
Danalioğlu, A	1
Poturoğlu, S	1
Güngör Güllüoğlu, M	1
Demir, K	1
Beşişik, F	1
Cakaloğlu, Y	1
Cevikbaş, U	1
Okten, A	1
Lenaerts, A	4
Codden, T	3
Henry, JP	3
Legros, F	1
Ligny, G	4
Economou, M	1
Kosta, P	1
Papadimitriou, K	1
Dib, N	1
Oberti, F	1
Calès, P	1
Thuluvath, PJ	1
Maheshwari, A	1
Yoo, HW	1
Schrier, RW	1
Parikh, C	1
Steare, S	1
Korula, J	1
Meunier, JC	3
Ramanampamonjy, RM	1
Razafimahefa, SH	1
Rajaonarivelo, P	1
Rajaona, HR	1
Mimidis, K	1
Papadopoulos, V	1
Kartalis, G	1
Rai, RR	1
Jain, P	1
Gómez Mont, F	1
Ramírez, C	1
Perches, A	1
Dorner, M	1
Frey, G	1
Earley, LE	1
Gagnon, O	1
Gertman, PM	1
Iber, FL	1
Pérez-Ayuso, RM	1
Arroyo, V	8
Gaya, J	1
Bory, F	3
Rimola, A	3
Rivera, F	2
Rodés, J	3
Descos, L	1
Gauthier, A	1
Levy, VG	2
Michel, H	1
Quinton, A	1
Rueff, B	1
Fermanian, J	1
Fombonne, E	1
Durbec, JP	1
Lissen Otero, E	1
Leal Noval, M	1
Lozano de León-Naranjo, F	1
Sánchez Quijano, A	1
Peláez Domínguez, S	1
Miranda Guisado, ML	1
Relimpio Ferrer, F	1
Andreu Kern, F	1
Schumpelick, V	1
Hrynyschyn, K	1
Kortmann, KB	1
Kuntz, E	1
Boyer, TD	1
Warnock, DG	1
Fogel, MR	1
Sawhney, VK	1
Neal, EA	1
Miller, RG	1
Knauer, CM	1
Gregory, PB	1
Greenway, B	1
Johnson, PJ	1
Williams, R	3
Babej, RM	1
Trevisani, F	1
Santini, C	1
Pini, P	1
Turci, P	1
Pandya, KJ	1
Whitehead, R	1
Crowley, J	1
Citrin, DL	1
Bosch, J	1
Casamitjana, R	1
Cabrera, J	3
Loew, D	1
Dýcka, J	1
Pfleiderer, T	1
Ritter, W	1
Clearfield, H	1
Van Vliet, AA	1
Kröger, R	1
Dubbelman, R	1
Ten Bokkel-Huinink, WW	1
Gerbes, AL	2
Pilz, A	1
Wernze, H	2
Jüngst, D	1
Knauf, H	2
Mutschler, E	2
Applefeld, JJ	1
Kasmer, RJ	1
Hak, LJ	1
Dukes, GE	1
Wermeling, DP	1
McClain, CJ	1
Ljubicić, N	2
Bilić, A	1
Kopjar, B	1
Fiaccadori, F	1
Pedretti, G	1
Pasetti, G	1
Pizzaferri, P	1
Elia, G	1
Nevens, F	1
Lijnen, P	1
VanBilloen, H	1
Fevery, J	1
de Luis, DA	1
Aller, R	1
Boixeda, D	1
Ruiz Del Arbol, L	1
De Argila, CM	1
Fernández-Esparrach, G	1
Guevara, M	2
Sort, P	2
Jiménez, W	2
Lebrec, D	1
Geuvel, A	1
Elewaut, A	1
Adler, M	1
Chang, SC	1
Chang, HI	1
Chen, FJ	1
Shiao, GM	1
Wang, SS	1
Lee, SD	1
Van Cauter, J	2
Moukaiber, H	1
Kujundzić, M	1
Banić, M	1
Vrkljan, M	1
Stanley, AJ	1
Forrest, EH	1
Dabos, KJ	1
MacGilchrist, AJ	1
Hayes, PC	1
Lööf, L	1
Prytz, H	1
Söderlund, C	1
Wallerstedt, S	1
Campra, JL	1
Reynolds, TB	4
Mackay, A	1
Stevenson, RD	1
Fuller, RK	1
Khambatta, PB	1
Gobezie, GC	1
Castagnolo, B	1
De Colibus, V	1
Napolitano, L	1
Aliperta, A	1
Caldarelli, G	1
Abignente, F	1
Delavelle, F	1
Becchio, J	1
Fries, D	1
Nierenberg, DW	1
Albert, JP	1
Wronski, R	1
Jentzen, F	1
Hartmann, F	1
Marra, N	1
Micheli, E	1
Spagnolo, G	1
Feinfeld, DA	1
Carvounis, CP	1
Vetter, H	1
Vetter, W	1
Beckerhoff, R	1
Glänzer, K	1
Furrer, J	1
Hahn, C	1
Kolloch, R	1
Krück, F	1
Kutz, K	1
Siegenthaler, W	1
Witassek, F	1
Radó, JP	4
Juhos, E	2
Sawinsky, I	1
Gayral, MN	1
Millet, D	1
Netter, A	1
Acharya, SK	1
Balwinder, S	1
Padhee, AK	1
Nijhawan, S	1
Tandon, BN	1
Hagège, H	1
Ink, O	1
Ducreux, M	1
Pelletier, G	1
Buffet, C	1
Etienne, JP	1
Runyon, BA	1
Antillon, MR	1
McHutchison, JG	1
Sungaila, I	1
Bartle, WR	1
Walker, SE	1
DeAngelis, C	1
Uetrecht, J	1
Pappas, C	1
Vidins, E	1
Schölmerich, J	2
Gatta, A	1
Caregaro, L	1
Menon, F	1
Sacerdoti, D	1
Merkel, C	1
el-Zayadi, A	1
Mohran, Z	1
Hasseeb, N	1
Nagy, N	1
Dabbous, H	1
Gentilini, P	1
Wenk, E	1
Goerg, KJ	1
Gerok, W	1
Leser, HG	1
Brunkhorst, R	1
Wrenger, E	1
Kühn, K	1
Schmidt, FW	1
Koch, K	1
Andriulli, A	2
Arrigoni, A	2
Gindro, T	2
Karbowiak, I	1
Buzzetti, G	1
Armanini, D	1
Viver, J	2
Bellati, G	1
Idéo, G	1
Sarin, SK	1
Sachdev, G	1
Mishra, SP	1
Sundaram, KR	1
Shrivastwa, A	1
Talukdar, V	1
Broor, SL	1
Verme, G	1
Panos, M	1
Camps, J	1
Bruckstein, AH	1
Veldhuyzen van Zanten, SJ	1
Sauerbruch, T	1
Medina, JF	1
Prieto, J	1
Guarner, F	1
Quiroga, J	1
Milazzo, A	1
Traina, M	1
Vizzini, GB	1
Kandel, G	1
Diamant, NE	1
Badalamenti, S	1
Pockros, PJ	1
Ventrella, F	1
Baldassarre, G	1
Vinciguerra, V	1
Spital, A	1
Decaux, G	1
Mols, P	1
Cauchie, P	1
Flamion, B	1
Delwiche, F	1
Senewiratne, B	2
Edmonds, CJ	1
Richards, P	1
Bodin, F	1
Liguory, C	1
Capelle, P	1
Aronoff, A	1
Nayarai, I	1
Huffman, DH	1
Conn, HO	1
Fukuchi, S	1
Goebell, H	1
Dölle, W	2
Aach, R	1
Kissane, J	1
Bsteh, O	1
Opitz, A	1
Felder, KD	1
Brunswig, D	1
Wilkinson, SP	1
Blendis, LM	1
Escartin Marín, P	1
Arenas Mirave, I	1
Alvarez Bustos, G	1
Arenas de Pablo, A	1
García Plaza, A	1
Munshi, CP	1
Sawkar, LA	1
Vaidya, PM	1
Gulati, OD	1
Linèt, O	1
Anderton, JL	1
Kincaid-Smith, P	1
Marosi, J	2
Takó, J	2
Dévényi, I	1
Papadoyanakis, N	1
Darsinos, J	1
Alexandrou, K	1
Karli, J	1
Horbach, L	1
Michaelis, J	1
Kaufmann, W	1
Dürr, F	1
Neuhaus, GA	1
Praetorius, F	1
Hillenbrand, P	1
Walker, JG	1
Scott, A	1
Savoye, B	1
Gayet, C	1
Eggert, RC	1
Yamada, S	1
Lassale, B	1
Del Corso, A	1
Caroli, J	1
Clarkson, EM	1
Luck, VA	1
Huchzermeyer, H	1
Gentili, G	1
Liberti, R	1
Loginov, AS	1
Berezov, VM	1
Perret, M	1
Bull, MB	1
Laragh, JH	1
Szende, L	1
Zinkevich, SV	1
Păunescu-Podanu, A	1
Demirian, H	1
Ionitã, C	1
Georgescu, D	1
Tarachiu, A	1
Anghel, R	1
Rubingher, L	1
Robert, M	1
Portmann, B	1
Mejicano, R	1
Weinreich, J	1
Weber, JC	1
Pasquier, J	1
Olivier, L	1
Tolot, F	1
Dechavannes, M	1
Fiere, D	1
Lieberman, FL	1
Fu, FY	1
T'ang, MK	1
Cheng, CS	1
Liu, H	1
Lu, ST	1
Oz, R	1
Colucci, CF	1
Arroyo, JL	1
Bueno, J	1
Rivero, A	1
Lucas, I	1
Ortiz de Landazuri, E	1