spironolactone has been researched along with Arthritis in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Arthritis: Acute or chronic inflammation of JOINTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy." | 5.32 | Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. ( Bendtzen, K; Hansen, PR; Rieneck, K, 2003) |
| "Dark red nodules that drained an opaque amber liquid developed on the extensor surfaces of both legs in a 69-year-old woman receiving furosemide and spironolactone for congestive heart failure." | 3.65 | Panniculitis of the legs with urate crystal deposition. ( Niemi, KM, 1977) |
| "Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy." | 1.32 | Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. ( Bendtzen, K; Hansen, PR; Rieneck, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bendtzen, K | 2 |
| Hansen, PR | 2 |
| Rieneck, K | 2 |
| Niemi, KM | 1 |
| Van Arman, CG | 1 |
| Nuss, GW | 1 |
| Risley, EA | 1 |
| Ikeda, T | 1 |
| Aspinall, RL | 1 |
1 review available for spironolactone and Arthritis
| Article | Year |
|---|---|
[Hypertension--diuretics as antihypertensive agents].
Topics: Aged; Antihypertensive Agents; Arthritis; Benzothiadiazines; Blood Pressure; Chlorothiazide; Chlorth | 1970 |
5 other studies available for spironolactone and Arthritis
| Article | Year |
|---|---|
Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid | 2003 |
[Spironolactone inhibits production of proinflammatory cytokines, including tumor necrosis factor-alpha and interferon-gamma and has potential effect in the treatment of arthritis].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid | 2004 |
Panniculitis of the legs with urate crystal deposition.
Topics: Aged; Arthritis; Diagnosis, Differential; Female; Furosemide; Gout; Heart Failure; Humans; Lipase; S | 1977 |
Interactions of aspirin, indomethacin and other drugs in adjuvant-induced arthritis in the rat.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Body Weight; Chlorpromazine; C | 1973 |
Differential effect of spironolactone on the ulcerogenic and anti-inflammatory activities of indomethacin.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Disease Models, Animal; Indomethacin; Intestines; Male | 1970 |