spironolactone has been researched along with Arthritis, Rheumatoid in 7 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day." | 7.74 | Hydroxychloroquine-induced hyperpigmentation: the staining pattern. ( Ferringer, T; Lountzis, NI; Puri, PK; Tyler, W, 2008) |
| "The frequency of left ventricular hypertrophy (LVH) dropped by 10% (χ²=3." | 6.94 | EFFICACY OF SPIRONOLACTONE IN ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH RESISTANT HYPERTENSION IN COMBINATION WITH RHEUMATOID ARTHRITIS. ( Hai, O; Karmazin, Y; Karmazina, O; Kondratiuk, V; Stakhova, A, 2020) |
| "Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy." | 5.32 | Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. ( Bendtzen, K; Hansen, PR; Rieneck, K, 2003) |
| "We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day." | 3.74 | Hydroxychloroquine-induced hyperpigmentation: the staining pattern. ( Ferringer, T; Lountzis, NI; Puri, PK; Tyler, W, 2008) |
| "The frequency of left ventricular hypertrophy (LVH) dropped by 10% (χ²=3." | 2.94 | EFFICACY OF SPIRONOLACTONE IN ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH RESISTANT HYPERTENSION IN COMBINATION WITH RHEUMATOID ARTHRITIS. ( Hai, O; Karmazin, Y; Karmazina, O; Kondratiuk, V; Stakhova, A, 2020) |
| "Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy." | 1.32 | Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. ( Bendtzen, K; Hansen, PR; Rieneck, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Kondratiuk, V | 1 |
| Stakhova, A | 1 |
| Hai, O | 1 |
| Karmazina, O | 1 |
| Karmazin, Y | 1 |
| Puri, PK | 1 |
| Lountzis, NI | 1 |
| Tyler, W | 1 |
| Ferringer, T | 1 |
| Wada, Y | 1 |
| Kobayashi, D | 1 |
| Murakami, S | 1 |
| Oda, M | 1 |
| Hanawa, H | 1 |
| Kuroda, T | 1 |
| Nakano, M | 1 |
| Narita, I | 1 |
| Bendtzen, K | 2 |
| Hansen, PR | 2 |
| Rieneck, K | 2 |
| Glasson, P | 1 |
| Gaillard, R | 1 |
| Riondel, A | 1 |
| Vallotton, MB | 1 |
| Nuki, G | 1 |
| Boddy, K | 1 |
| Kennedy, AC | 1 |
| King, P | 1 |
| Duncan, AM | 1 |
| Buchanan, WW | 1 |
1 trial available for spironolactone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
EFFICACY OF SPIRONOLACTONE IN ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH RESISTANT HYPERTENSION IN COMBINATION WITH RHEUMATOID ARTHRITIS.
Topics: Aged; Antihypertensive Agents; Arthritis, Rheumatoid; Echocardiography; Female; Humans; Hypertension | 2020 |
6 other studies available for spironolactone and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Hydroxychloroquine-induced hyperpigmentation: the staining pattern.
Topics: Aged; Antacids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents | 2008 |
Cardiac AA amyloidosis in a patient with rheumatoid arthritis and systemic sclerosis: the therapeutic potential of biological reagents.
Topics: Aged; Amyloidosis; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Benzimidazo | 2011 |
Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid | 2003 |
[Spironolactone inhibits production of proinflammatory cytokines, including tumor necrosis factor-alpha and interferon-gamma and has potential effect in the treatment of arthritis].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid | 2004 |
Role of renal prostaglandins and relationship to renin, aldosterone, and antidiuretic hormone during salt depletion in man.
Topics: Adult; Aged; Aldosterone; Arginine Vasopressin; Arthritis, Rheumatoid; Diet, Sodium-Restricted; Fema | 1979 |
Potassium metabolism in patients with rheumatoid arthritis. Effects of treatment with depot tetracosactrin, spironolactone, and oral supplements of potassium chloride.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Pressure; Electrocardiography; Erythrocytes; Female; Human | 1975 |