spironolactone has been researched along with Arthritis, Juvenile in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Arthritis, Juvenile: Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy." | 5.32 | Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. ( Bendtzen, K; Hansen, PR; Rieneck, K, 2003) |
| "A rare case of childhood pulmonary haemosiderosis with juvenile idiopathic arthritis is discussed, with particular reference to treatment with hydroxychloroquine and sildenafil for pulmonary hypertension which occurs secondary to this disease." | 3.74 | Pulmonary haemosiderosis with juvenile idiopathic arthritis in a Malaysian child. ( Noor, AS; Quah, BS; Rasool, AH; Roberton, D; Wong, AR, 2007) |
| "Spironolactone therapy was generally well tolerated, although treatment had to be stopped in two adults on concomitant methotrexate therapy." | 1.32 | Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. ( Bendtzen, K; Hansen, PR; Rieneck, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, AR | 1 |
| Noor, AS | 1 |
| Rasool, AH | 1 |
| Quah, BS | 1 |
| Roberton, D | 1 |
| Bendtzen, K | 2 |
| Hansen, PR | 2 |
| Rieneck, K | 2 |
3 other studies available for spironolactone and Arthritis, Juvenile
| Article | Year |
|---|---|
Pulmonary haemosiderosis with juvenile idiopathic arthritis in a Malaysian child.
Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Juvenile; Female; Hemosideros | 2007 |
Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid | 2003 |
[Spironolactone inhibits production of proinflammatory cytokines, including tumor necrosis factor-alpha and interferon-gamma and has potential effect in the treatment of arthritis].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid | 2004 |