spironolactone has been researched along with Aortic Aneurysm, Abdominal in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA)." | 7.73 | Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. ( Cassis, LA; Daugherty, A; Helton, MJ; Howatt, DA; King, VL, 2005) |
| "Serum potassium concentration should be measured immediately before operation to detect hyperkalemia in heart failure patients treated with spironolactone." | 7.71 | Life-threatening hyperkalemia: a complication of spironolactone for heart failure in a patient with renal insufficiency. ( Carpenter, JP; Cheung, AT; Hu, Y, 2002) |
| "We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA)." | 3.73 | Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. ( Cassis, LA; Daugherty, A; Helton, MJ; Howatt, DA; King, VL, 2005) |
| "Serum potassium concentration should be measured immediately before operation to detect hyperkalemia in heart failure patients treated with spironolactone." | 3.71 | Life-threatening hyperkalemia: a complication of spironolactone for heart failure in a patient with renal insufficiency. ( Carpenter, JP; Cheung, AT; Hu, Y, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, S | 1 |
| Xie, Z | 1 |
| Daugherty, A | 2 |
| Cassis, LA | 2 |
| Pearson, KJ | 1 |
| Gong, MC | 1 |
| Guo, Z | 1 |
| Helton, MJ | 1 |
| Howatt, DA | 1 |
| King, VL | 1 |
| Hu, Y | 1 |
| Carpenter, JP | 1 |
| Cheung, AT | 1 |
3 other studies available for spironolactone and Aortic Aneurysm, Abdominal
| Article | Year |
|---|---|
Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.
Topics: Aldosterone; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anim | 2013 |
Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Topics: Aldosterone; Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Arteriosclerosi | 2005 |
Life-threatening hyperkalemia: a complication of spironolactone for heart failure in a patient with renal insufficiency.
Topics: Aged; Aortic Aneurysm, Abdominal; Blood Gas Analysis; Heart Failure; Humans; Hyperkalemia; Intraoper | 2002 |