spironolactone has been researched along with Anoxemia in 22 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated the efficacy of MR antagonism by spironolactone in two experimental PH models; mouse chronic hypoxia-induced PH (prevention model) and rat monocrotaline-induced PH (prevention and treatment models)." | 3.79 | Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension. ( Fanburg, BL; Hill, NS; Jaffe, IZ; Preston, IR; Sagliani, KD; Warburton, RR, 2013) |
| " The regime used was spironolactone in a dosage of 25 mg three times a day for two days preceding and during the periods spent at altitudes above 3,000 m." | 1.26 | Spironolactone and acute mountain sickness. ( Carter, PH; Champion, WL; Currie, TT; Fong, G; Francis, JK; McDonald, IH; Newing, RK; Nunn, IN; Sisson, RN; Sussex, M; Zacharin, RF, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (81.82) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Grimmer, B | 1 |
| Krauszman, A | 1 |
| Hu, X | 1 |
| Kabir, G | 1 |
| Connelly, KA | 1 |
| Li, M | 1 |
| Grune, J | 1 |
| Madry, C | 1 |
| Isakson, BE | 1 |
| Kuebler, WM | 1 |
| Preston, IR | 1 |
| Sagliani, KD | 1 |
| Warburton, RR | 1 |
| Hill, NS | 1 |
| Fanburg, BL | 1 |
| Jaffe, IZ | 1 |
| Yim, HE | 1 |
| Kim, JH | 1 |
| Yoo, KH | 1 |
| Bae, IS | 1 |
| Hong, YS | 1 |
| Lee, JW | 1 |
| RAAB, W | 1 |
| Christian, N | 1 |
| Bol, A | 1 |
| De Bast, M | 1 |
| Labar, D | 1 |
| Lee, J | 1 |
| Mahy, P | 1 |
| Grégoire, V | 1 |
| Jain, SC | 2 |
| Singh, MV | 2 |
| Rawal, SB | 2 |
| Turnbull, G | 1 |
| Rutter, LD | 1 |
| Meyers, DH | 1 |
| Ramsay, LE | 1 |
| Löllgen, H | 1 |
| Löllgen-Horres, I | 1 |
| von Nieding, G | 1 |
| McFarlane, AC | 2 |
| Brookfield, DS | 1 |
| Liston, WA | 1 |
| Brown, GV | 1 |
| Currie, TT | 2 |
| Snell, JA | 1 |
| Cordner, EP | 1 |
| Carter, PH | 1 |
| Champion, WL | 1 |
| Fong, G | 1 |
| Francis, JK | 1 |
| McDonald, IH | 1 |
| Newing, RK | 1 |
| Nunn, IN | 1 |
| Sisson, RN | 1 |
| Sussex, M | 1 |
| Zacharin, RF | 1 |
| Larsen, RF | 1 |
| Rock, PB | 1 |
| Fulco, CS | 1 |
| Edelman, B | 1 |
| Young, AJ | 1 |
| Cymerman, A | 1 |
| Sharma, VM | 1 |
| Tyagi, AK | 1 |
| Coraboeuf, E | 1 |
| Deroubaix, E | 1 |
| Sutton, J | 1 |
| Lazarus, L | 1 |
1 review available for spironolactone and Anoxemia
| Article | Year |
|---|---|
NEUROGENIC MULTIFOCAL DESTRUCTION OF MYOCARDIAL TISSUE (PATHOGENIC MECHANISM AND ITS PREVENTION).
Topics: Adrenal Cortex Hormones; Catecholamines; Epinephrine; Heart Diseases; Hypoxia; Myocardial Infarction | 1963 |
4 trials available for spironolactone and Anoxemia
| Article | Year |
|---|---|
Spironolactone prophylaxis in mountain sickness.
Topics: Altitude Sickness; Female; Humans; Hypoxia; Male; Mountaineering; Spironolactone | 1980 |
Spironolactone in acute mountain sickness.
Topics: Adolescent; Adult; Altitude Sickness; Child; Clinical Trials as Topic; Humans; Hypoxia; Mountaineeri | 1977 |
Use of spironolactone in the prevention of acute mountain sickness on Kilimanjaro.
Topics: Acute Disease; Adolescent; Adult; Altitude Sickness; Child; Double-Blind Method; Humans; Hypoxia; Mo | 1977 |
Effect of spironolactone on acute mountain sickness.
Topics: Acute Disease; Adult; Double-Blind Method; Humans; Hypoxia; Male; Placebos; Random Allocation; Spiro | 1986 |
17 other studies available for spironolactone and Anoxemia
| Article | Year |
|---|---|
Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction.
Topics: Adenosine Triphosphate; Animals; Calcium; Connexins; HeLa Cells; Humans; Hypertension, Pulmonary; Hy | 2022 |
Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension.
Topics: Aldosterone; Animals; Arterial Pressure; Body Weight; Cardiac Output; Cell Proliferation; Fibrosis; | 2013 |
Spironolactone and enalapril differentially up-regulate the expression of VEGF and heme oxygenase-1 in the neonatal rat kidney.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Blotting, Western; Enalapril; G | 2011 |
Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model.
Topics: Animals; Area Under Curve; Hypoxia; Liver; Male; Mice; Mice, Inbred C3H; Neoplasms; Nitroimidazoles; | 2007 |
The effects of acetazolamide and spironolactone on the body water distribution of rabbits during acute exposure to simulated altitude.
Topics: Acetazolamide; Altitude Sickness; Animals; Body Water; Hypoxia; Male; Rabbits; Spironolactone | 1984 |
Spironolactone prophylaxis in mountain sickness.
Topics: Altitude Sickness; Humans; Hypoxia; Mountaineering; Spironolactone | 1980 |
Spironolactone prophylaxis of mountain sickness.
Topics: Altitude Sickness; Humans; Hypoxia; Male; Mountaineering; Spironolactone | 1980 |
Prophylaxis of acute mountain sickness.
Topics: Acetazolamide; Acute Disease; Altitude Sickness; Humans; Hypoxia; Mountaineering; Nepal; Spironolact | 1977 |
[Therapy of chronic non-specific respiratory tract diseases. 2. Therapy of infection, oxygen therapy, supplementary therapy].
Topics: Adrenocorticotropic Hormone; Bacterial Infections; Bronchitis; Cortisone; Digitalis Glycosides; Huma | 1976 |
Spironolactone and acute mountain sickness.
Topics: Aldosterone; Altitude Sickness; Humans; Hypoxia; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Acute Disease; Altitude Sickness; Humans; Hypoxia; Mountaineering; Plasma Volume; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Adult; Altitude Sickness; Female; Humans; Hypoxia; Male; Middle Aged; Mountaineering; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Acute Disease; Adult; Altitude Sickness; Aspirin; Female; Furosemide; Humans; Hypoxia; Male; Middle | 1976 |
Spironolactone and acute moutain sickness.
Topics: Acute Disease; Altitude Sickness; Humans; Hypoxia; Mountaineering; Spironolactone | 1976 |
Amelioration of acute mountain sickness: comparative study of acetazolamide and spironolactone.
Topics: Acetazolamide; Adult; Altitude Sickness; Humans; Hypoxia; Male; Spironolactone | 1986 |
Effect of a spirolactone derivative, sodium canrenoate, on mechanical and electrical activities of isolated rat myocardium.
Topics: Acetylcholine; Action Potentials; Adrenal Glands; Adrenalectomy; Animals; Carboxylic Acids; Coronary | 1974 |
Mountain sickness in the Australian alps.
Topics: Adolescent; Adult; Aged; Altitude; Aspirin; Australia; Child; Female; Humans; Hypoxia; Male; Menstru | 1973 |