spironolactone has been researched along with Androgenization in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Such effects depend not only on increased androgen production by the ovary or adrenal gland but also on the bioavailability of androgen to peripheral tissues." | 2.37 | Anti-androgens in gynaecological practice. ( Franks, S; Reed, MJ, 1988) |
| " A dose-response study measured the effects of SPL on anal fin ray elongation, an androgen-dependent secondary sex trait, and expression of the vitellogenin gene, an estrogen-dependent trait, in female western mosquitofish, Gambusia affinis." | 1.37 | Endocrine-disrupting effects of spironolactone in female western mosquitofish, Gambusia affinis. ( Angus, RA; Howell, WM; Raut, SA, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raut, SA | 1 |
| Howell, WM | 1 |
| Angus, RA | 1 |
| Rajput, R | 1 |
| Bhansali, A | 1 |
| Singh, R | 1 |
| Reed, MJ | 1 |
| Franks, S | 1 |
| Melby, JC | 1 |
2 reviews available for spironolactone and Androgenization
| Article | Year |
|---|---|
Anti-androgens in gynaecological practice.
Topics: Acne Vulgaris; Androgen Antagonists; Androgens; Cyproterone; Female; Hirsutism; Humans; Spironolacto | 1988 |
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldoster | 1971 |
2 other studies available for spironolactone and Androgenization
| Article | Year |
|---|---|
Endocrine-disrupting effects of spironolactone in female western mosquitofish, Gambusia affinis.
Topics: Androgen Antagonists; Androgens; Animal Fins; Animals; Cyprinodontiformes; Dose-Response Relationshi | 2011 |
Ovarian hyperthecosis and response to antiandrogens: An uncommon presentation of a common disorder.
Topics: Adolescent; Androgen Antagonists; Contraceptives, Oral, Hormonal; Female; Humans; Polycystic Ovary S | 2008 |