spironolactone and Alveolar Bone Atrophy studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Research Excerpts

Excerpt	Relevance	Reference
"In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor."	5.33	The effect of spironolactone on experimental periodontitis in rats. ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005)
"In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor."	1.33	The effect of spironolactone on experimental periodontitis in rats. ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

spironolactone and Alveolar Bone Atrophy

Research Excerpts

Research

Studies (1)

Authors

Other Studies

Authors	Studies
Grauballe, MC	1
Bentzen, BH	1
Björnsson, M	1
Moe, D	1
Jonassen, TE	1
Bendtzen, K	1
Stoltze, K	1
Holmstrup, P	1