spironolactone has been researched along with Altitude Hypoxia in 17 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Altitude Hypoxia: Low ambient oxygen tension associated with ALTITUDE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetazolamide was more effective than spironolactone in preventing AMS (OR = 0." | 2.76 | Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group). ( Alexander, HD; Basnyat, B; Farrar, J; Gertsch, J; Halverson, S; Holck, PS; Joshi, A; Karambay, J; Khanal, S; Morrissey, C; Powell, S; Pun, M; Shankar, R; Steif, M; Stone, A; Szawarski, P; Thompson, BH, 2011) |
| " The regime used was spironolactone in a dosage of 25 mg three times a day for two days preceding and during the periods spent at altitudes above 3,000 m." | 1.26 | Spironolactone and acute mountain sickness. ( Carter, PH; Champion, WL; Currie, TT; Fong, G; Francis, JK; McDonald, IH; Newing, RK; Nunn, IN; Sisson, RN; Sussex, M; Zacharin, RF, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonzalez Garay, A | 1 |
| Molano Franco, D | 1 |
| Nieto Estrada, VH | 1 |
| MartÃ-Carvajal, AJ | 1 |
| Arevalo-Rodriguez, I | 1 |
| Basnyat, B | 1 |
| Holck, PS | 1 |
| Pun, M | 1 |
| Halverson, S | 1 |
| Szawarski, P | 1 |
| Gertsch, J | 1 |
| Steif, M | 1 |
| Powell, S | 1 |
| Khanal, S | 1 |
| Joshi, A | 1 |
| Shankar, R | 1 |
| Karambay, J | 1 |
| Alexander, HD | 1 |
| Stone, A | 1 |
| Morrissey, C | 1 |
| Thompson, BH | 1 |
| Farrar, J | 1 |
| Jain, SC | 2 |
| Singh, MV | 2 |
| Rawal, SB | 2 |
| Turnbull, G | 1 |
| Rutter, LD | 1 |
| Meyers, DH | 1 |
| Coote, JH | 1 |
| Schnur, W | 1 |
| Ramsay, LE | 1 |
| McFarlane, AC | 2 |
| Brookfield, DS | 1 |
| Liston, WA | 1 |
| Brown, GV | 1 |
| Currie, TT | 2 |
| Snell, JA | 1 |
| Cordner, EP | 1 |
| Carter, PH | 1 |
| Champion, WL | 1 |
| Fong, G | 1 |
| Francis, JK | 1 |
| McDonald, IH | 1 |
| Newing, RK | 1 |
| Nunn, IN | 1 |
| Sisson, RN | 1 |
| Sussex, M | 1 |
| Zacharin, RF | 1 |
| Sharma, VM | 1 |
| Tyagi, AK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Double-Blind Control Trial Evaluating the Utility of Continuous Positive Airway Pressure (CPAP) in the Treatment of High Altitude Pulmonary Edema (HAPE)[NCT04186598] | 264 participants (Anticipated) | Interventional | 2020-01-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for spironolactone and Altitude Hypoxia
| Article | Year |
|---|---|
Interventions for preventing high altitude illness: Part 2. Less commonly-used drugs.
Topics: Acetazolamide; Altitude Sickness; Cathartics; Citric Acid; Diuretics; Humans; Organometallic Compoun | 2018 |
Medicine and mechanisms in altitude sickness. Recommendations.
Topics: Acetazolamide; Altitude Sickness; Carbonic Anhydrase Inhibitors; Dexamethasone; Glucocorticoids; Hum | 1995 |
4 trials available for spironolactone and Altitude Hypoxia
| Article | Year |
|---|---|
Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group).
Topics: Acetazolamide; Adult; Altitude Sickness; Double-Blind Method; Female; Headache; Humans; Male; Mounta | 2011 |
Spironolactone prophylaxis in mountain sickness.
Topics: Altitude Sickness; Female; Humans; Hypoxia; Male; Mountaineering; Spironolactone | 1980 |
Spironolactone in acute mountain sickness.
Topics: Adolescent; Adult; Altitude Sickness; Child; Clinical Trials as Topic; Humans; Hypoxia; Mountaineeri | 1977 |
Use of spironolactone in the prevention of acute mountain sickness on Kilimanjaro.
Topics: Acute Disease; Adolescent; Adult; Altitude Sickness; Child; Double-Blind Method; Humans; Hypoxia; Mo | 1977 |
11 other studies available for spironolactone and Altitude Hypoxia
| Article | Year |
|---|---|
The effects of acetazolamide and spironolactone on the body water distribution of rabbits during acute exposure to simulated altitude.
Topics: Acetazolamide; Altitude Sickness; Animals; Body Water; Hypoxia; Male; Rabbits; Spironolactone | 1984 |
Spironolactone prophylaxis in mountain sickness.
Topics: Altitude Sickness; Humans; Hypoxia; Mountaineering; Spironolactone | 1980 |
Spironolactone prophylaxis of mountain sickness.
Topics: Altitude Sickness; Humans; Hypoxia; Male; Mountaineering; Spironolactone | 1980 |
Preventing acute mountain sickness.
Topics: Acute Disease; Altitude Sickness; Diuretics; Humans; Spironolactone | 2001 |
Prophylaxis of acute mountain sickness.
Topics: Acetazolamide; Acute Disease; Altitude Sickness; Humans; Hypoxia; Mountaineering; Nepal; Spironolact | 1977 |
Spironolactone and acute mountain sickness.
Topics: Aldosterone; Altitude Sickness; Humans; Hypoxia; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Acute Disease; Altitude Sickness; Humans; Hypoxia; Mountaineering; Plasma Volume; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Adult; Altitude Sickness; Female; Humans; Hypoxia; Male; Middle Aged; Mountaineering; Spironolactone | 1977 |
Spironolactone and acute mountain sickness.
Topics: Acute Disease; Adult; Altitude Sickness; Aspirin; Female; Furosemide; Humans; Hypoxia; Male; Middle | 1976 |
Spironolactone and acute moutain sickness.
Topics: Acute Disease; Altitude Sickness; Humans; Hypoxia; Mountaineering; Spironolactone | 1976 |
Amelioration of acute mountain sickness: comparative study of acetazolamide and spironolactone.
Topics: Acetazolamide; Adult; Altitude Sickness; Humans; Hypoxia; Male; Spironolactone | 1986 |