spironolactone has been researched along with Alcoholism in 19 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined." | 5.25 | Spironolactone diuresis in patients with cirrhosis and ascites. ( Eggert, RC, 1970) |
| " A simple clinical method using the urinary Na/K ratio as a guide to spironolactone dosage is outlined." | 1.25 | Spironolactone diuresis in patients with cirrhosis and ascites. ( Eggert, RC, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (94.74) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Farokhnia, M | 1 |
| Rentsch, CT | 1 |
| Chuong, V | 1 |
| McGinn, MA | 1 |
| Elvig, SK | 1 |
| Douglass, EA | 1 |
| Gonzalez, LA | 1 |
| Sanfilippo, JE | 1 |
| Marchette, RCN | 1 |
| Tunstall, BJ | 1 |
| Fiellin, DA | 1 |
| Koob, GF | 1 |
| Justice, AC | 1 |
| Leggio, L | 1 |
| Vendruscolo, LF | 1 |
| GARVOCK, WB | 1 |
| EZRIN, C | 1 |
| TAYLOR, R | 1 |
| GIRARD, M | 1 |
| GEFFROY, Y | 1 |
| DESHAYES, P | 1 |
| FABLET, J | 1 |
| CAYRON, G | 1 |
| CACHIN, M | 1 |
| LEVY, C | 1 |
| VARAY, A | 1 |
| BERTHELOT, J | 1 |
| BLONDON, J | 1 |
| BLERY, M | 1 |
| DUPUY, R | 1 |
| VALLIN, J | 1 |
| BOUTELLIER, D | 1 |
| LODS, JC | 1 |
| Sabesin, SM | 1 |
| Hays, RA | 1 |
| Trewby, PN | 1 |
| Aron, DC | 1 |
| Tyrrell, JB | 1 |
| Fitzgerald, PA | 1 |
| Findling, JW | 1 |
| Forsham, PH | 1 |
| Bossone, CM | 1 |
| Mahood, JM | 1 |
| Savoye, B | 1 |
| Gayet, C | 1 |
| Eggert, RC | 1 |
| Vesin, P | 1 |
| Fraisse, H | 1 |
| Perret, M | 1 |
| Etaix, JP | 1 |
| Robert, M | 1 |
| Portmann, B | 1 |
| Steigmann, F | 1 |
| Mejicano, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Spironolactone in Alcohol Use Disorder (SAUD): A Double-Blind, Placebo-Controlled, Ascending Dose, Phase 1b Study[NCT05807139] | Phase 1 | 20 participants (Anticipated) | Interventional | 2024-01-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spironolactone and Alcoholism
| Article | Year |
|---|---|
Drug-induced peptic ulcer and upper gastrointestinal bleeding.
Topics: Adrenal Cortex Hormones; Alcoholism; Animals; Aspirin; Diuretics; Emepronium; Female; Gastrointestin | 1980 |
18 other studies available for spironolactone and Alcoholism
| Article | Year |
|---|---|
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies.
Topics: Alcohol Drinking; Alcoholism; Animals; Cohort Studies; Ethanol; Female; Humans; Male; Mice; Rats; Ro | 2022 |
Therapeutic conference on diuretics.
Topics: Alcoholism; Ascites; Chlorothiazide; Diuretics; Organomercury Compounds; Prednisone; Spironolactone | 1961 |
[THE TREATMENT OF ALCOHOLIC CIRRHOSIS].
Topics: Adrenal Cortex Hormones; Alcoholism; Arginine; Diet; Diet Therapy; Diuretics; Folic Acid; Glutamates | 1963 |
[OUR EXPERIENCE WITH SPIROLACTONE IN THE TREATMENT OF DECOMPENSATED CIRRHOSIS].
Topics: Alcoholism; Ascites; Liver Cirrhosis; Spironolactone | 1963 |
[INDICATIONS FOR SPIROLACTONE IN ASCITIC CIRRHOSIS].
Topics: Alcoholism; Ascites; Chlorothiazide; Liver Cirrhosis; Prednisone; Spironolactone | 1963 |
[THERAPEUTIC INCIDENCES IN ASCITIC NUTRITIONAL CIRRHOSIS WITH JAUNDICE].
Topics: Adrenal Cortex Hormones; Alcoholism; Anti-Bacterial Agents; Ascites; Chlorothiazide; Diagnosis, Diff | 1963 |
[INDICATIONS FOR THE TREATMENT OF ASCITIC CIRRHOSIS ACCORDING TO ITS CLINICAL FORMS].
Topics: Alcoholism; Ascites; Benzothiadiazines; Diet, Reducing; Diet, Sodium-Restricted; Diuretics; Liver Ci | 1963 |
Fever, diaphoresis, and jaundice in an alcoholic.
Topics: Adult; Alcoholism; Fever; Hepatitis, Alcoholic; Humans; Hyperhidrosis; Jaundice; Male; Spironolacton | 1984 |
Cushing's syndrome: problems in diagnosis.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult; | 1981 |
The liver: a pharmacologic perspective.
Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec | 1977 |
Alcohol-induced Cushingoid syndrome: a false diagnosis.
Topics: Alcoholism; Cushing Syndrome; Diagnostic Errors; Heart Failure; Humans; Male; Middle Aged; Spironola | 1977 |
Medical grand rounds from the University of Alabama Medical Center.
Topics: Alcoholism; Antacids; Ascites; Biopsy; Blood Transfusion; Collateral Circulation; Esophageal and Gas | 1969 |
[Current treatment of the edematous ascitic syndrome in alcoholic liver cirrhosis].
Topics: Adrenal Cortex Hormones; Alcoholism; Ascites; Diet Therapy; Diuretics; Edema; Humans; Liver Cirrhosi | 1969 |
Spironolactone diuresis in patients with cirrhosis and ascites.
Topics: Alcoholism; Aldosterone; Ascites; Humans; Liver Cirrhosis; Potassium; Sodium; Spironolactone | 1970 |
[Treatment of cirrhotic edemas with triamterene, amiloride and spirolactone. New clinical and biological facts].
Topics: Adult; Alcoholism; Ascites; Diuretics; Edema; Female; Humans; Liver Cirrhosis; Middle Aged; Natriure | 1971 |
[Contribution to the study of the treatment of the ascitic syndrome of cirrhosis by the combination of spironolactone and sulfonamide diuretic. Initial therapy and supportive therapy. Apropos of 55 cases].
Topics: Adult; Aged; Alcoholism; Ascites; Benzothiadiazines; Diuretics; Female; Humans; Liver Cirrhosis; Mal | 1967 |
[Influence of diuretics on the survival of 180 patients with cirrhosis of the liver and ascites].
Topics: Adult; Aged; Alcoholism; Ascites; Chlorothiazide; Chlorthalidone; Diuretics; Ethacrynic Acid; Humans | 1969 |
The impact of diuretics on chronic liver disease.
Topics: Alcoholism; Ascites; Chlorothiazide; Diet Therapy; Diuretics; Ethacrynic Acid; Furosemide; Humans; L | 1969 |