spironolactone has been researched along with Alcohol Drinking in 9 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There was a significant dose-response relationship between spironolactone dosage and change in drinks/week." | 1.62 | Effectiveness of spironolactone dispensation in reducing weekly alcohol use: a retrospective high-dimensional propensity score-matched cohort study. ( Chi, FW; Elson, J; Farokhnia, M; Kline-Simon, AH; Leggio, L; Palzes, VA; Sterling, S; Weisner, C, 2021) |
| "Spironolactone treatment (7 days) was started following 3-day habituation to intragastric vehicle administration." | 1.48 | Marinobufagenin in Urine: A Potential Marker of Predisposition to Ethanol and a Target for Spironolactone. ( Bagrov, AY; Egorov, AY; Kashkin, VA; Shekunova, EV, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Farokhnia, M | 2 |
| Rentsch, CT | 1 |
| Chuong, V | 1 |
| McGinn, MA | 1 |
| Elvig, SK | 1 |
| Douglass, EA | 1 |
| Gonzalez, LA | 1 |
| Sanfilippo, JE | 1 |
| Marchette, RCN | 1 |
| Tunstall, BJ | 1 |
| Fiellin, DA | 1 |
| Koob, GF | 1 |
| Justice, AC | 1 |
| Leggio, L | 2 |
| Vendruscolo, LF | 1 |
| Makhijani, VH | 1 |
| Irukulapati, P | 1 |
| Van Voorhies, K | 1 |
| Fortino, B | 1 |
| Besheer, J | 1 |
| Palzes, VA | 1 |
| Kline-Simon, AH | 1 |
| Elson, J | 1 |
| Sterling, S | 1 |
| Weisner, C | 1 |
| Chi, FW | 1 |
| Kashkin, VA | 1 |
| Shekunova, EV | 1 |
| Egorov, AY | 1 |
| Bagrov, AY | 1 |
| Koenig, HN | 1 |
| Olive, MF | 1 |
| Fahlke, C | 2 |
| Hård, E | 2 |
| Eriksson, CJ | 1 |
| Engel, JA | 1 |
| Hansen, S | 2 |
| de Luis, DA | 1 |
| Aller, R | 1 |
| Boixeda, D | 1 |
| Ruiz Del Arbol, L | 1 |
| De Argila, CM | 1 |
| Miyazaki, T | 1 |
| Araki, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Spironolactone in Alcohol Use Disorder (SAUD): A Double-Blind, Placebo-Controlled, Ascending Dose, Phase 1b Study[NCT05807139] | Phase 1 | 20 participants (Anticipated) | Interventional | 2024-01-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spironolactone and Alcohol Drinking
| Article | Year |
|---|---|
[Abnormal steroid hormone metabolism during administration of various drugs].
Topics: Alcohol Drinking; Animals; Barbiturates; Estradiol; Humans; Hydrocortisone; Hypertension; Male; Meta | 1979 |
8 other studies available for spironolactone and Alcohol Drinking
| Article | Year |
|---|---|
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies.
Topics: Alcohol Drinking; Alcoholism; Animals; Cohort Studies; Ethanol; Female; Humans; Male; Mice; Rats; Ro | 2022 |
Central amygdala mineralocorticoid receptors modulate alcohol self-administration.
Topics: Alcohol Drinking; Animals; Central Amygdaloid Nucleus; Central Nervous System Depressants; Dose-Resp | 2020 |
Effectiveness of spironolactone dispensation in reducing weekly alcohol use: a retrospective high-dimensional propensity score-matched cohort study.
Topics: Adult; Alcohol Drinking; Cohort Studies; Female; Humans; Male; Middle Aged; Propensity Score; Retros | 2021 |
Marinobufagenin in Urine: A Potential Marker of Predisposition to Ethanol and a Target for Spironolactone.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Biomarkers; Blood Pressure; Bufanolides; Ethanol; Male; | 2018 |
The glucocorticoid receptor antagonist mifepristone reduces ethanol intake in rats under limited access conditions.
Topics: Alcohol Drinking; Animals; Choice Behavior; Dose-Response Relationship, Drug; Drinking; Drinking Beh | 2004 |
Consequence of long-term exposure to corticosterone or dexamethasone on ethanol consumption in the adrenalectomized rat, and the effect of type I and type II corticosteroid receptor antagonists.
Topics: Adrenalectomy; Alcohol Drinking; Animals; Body Weight; Corticosterone; Dexamethasone; Drinking; Drug | 1995 |
Facilitation of ethanol consumption by intracerebroventricular infusions of corticosterone.
Topics: Adrenalectomy; Alcohol Drinking; Animals; Corticosterone; Drinking; Injections, Intraventricular; Ma | 1996 |
Spontaneous bacterial peritonitis caused by Citrobacter diversus: case report.
Topics: Aged; Alcohol Drinking; Ascites; Cefotaxime; Cephalosporins; Citrobacter; Diagnosis, Differential; D | 1997 |