spironolactone has been researched along with Agranulocytosis in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of agranulocytosis secondary to spironolactone in a patient with cryptogenic liver disease." | 7.69 | Spironolactone-induced agranulocytosis. ( Pérgola, PE; Sang, JL; Talbert, RL; Whitling, AM, 1997) |
| "Agranulocytosis associated with spironolactone administration is described in a 57-year-old man." | 7.67 | Spironolactone-induced agranulocytosis. ( Friesen, EG; Jivraj, KT; Johnston, RG; Konopad, EM; Noseworthy, TW; Shustack, AS, 1987) |
| "Spironolactone was prescribed for diuresis beginning on the third day." | 6.42 | Spironolactone-induced agranulocytosis: a case report. ( Hsiao, SH; Hsu, MY; Lin, YJ; Wu, TJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsiao, SH | 1 |
| Lin, YJ | 1 |
| Hsu, MY | 1 |
| Wu, TJ | 1 |
| Stricker, BH | 1 |
| Oei, TT | 1 |
| Whitling, AM | 1 |
| Pérgola, PE | 1 |
| Sang, JL | 1 |
| Talbert, RL | 1 |
| Hui, CH | 1 |
| Das, PK | 1 |
| Horvath, N | 1 |
| Jivraj, KT | 1 |
| Noseworthy, TW | 1 |
| Friesen, EG | 1 |
| Shustack, AS | 1 |
| Konopad, EM | 1 |
| Johnston, RG | 1 |
| Schmidt, P | 1 |
1 review available for spironolactone and Agranulocytosis
| Article | Year |
|---|---|
Spironolactone-induced agranulocytosis: a case report.
Topics: Adult; Agranulocytosis; Female; Humans; Spironolactone | 2003 |
5 other studies available for spironolactone and Agranulocytosis
| Article | Year |
|---|---|
Agranulocytosis caused by spironolactone.
Topics: Aged; Agranulocytosis; Female; Humans; Leukocyte Count; Spironolactone | 1984 |
Spironolactone-induced agranulocytosis.
Topics: Agranulocytosis; Bone Marrow; Diuretics; Female; Granulocytes; Humans; Leukocyte Count; Middle Aged; | 1997 |
Spironolactone and agranulocytosis.
Topics: Aged; Agranulocytosis; Diuretics; Humans; Male; Spironolactone | 2000 |
Spironolactone-induced agranulocytosis.
Topics: Agranulocytosis; Humans; Leukocyte Count; Male; Middle Aged; Spironolactone | 1987 |
[Diuresis and diuretics].
Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder | 1971 |