spironolactone has been researched along with Aggression in 7 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently we demonstrated that corticosterone exerts an acute facilitatory effect on aggression in male rats." | 7.70 | The active phase-related increase in corticosterone and aggression are linked. ( de Kloet, RE; Haller, J; Kruk, MR; Millar, S; van de Schraaf, J, 2000) |
| "Recently we demonstrated that corticosterone exerts an acute facilitatory effect on aggression in male rats." | 3.70 | The active phase-related increase in corticosterone and aggression are linked. ( de Kloet, RE; Haller, J; Kruk, MR; Millar, S; van de Schraaf, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruiz-Aizpurua, L | 1 |
| Buwalda, B | 1 |
| De Boer, SF | 1 |
| Kruk, MR | 3 |
| Haller, J | 3 |
| Meelis, W | 1 |
| de Kloet, ER | 1 |
| Schjolden, J | 1 |
| Basic, D | 1 |
| Winberg, S | 1 |
| Calfa, G | 1 |
| Bussolino, D | 1 |
| Molina, VA | 1 |
| Millar, S | 2 |
| van de Schraaf, J | 1 |
| de Kloet, RE | 1 |
| Laue, L | 1 |
| Kenigsberg, D | 1 |
| Pescovitz, OH | 1 |
| Hench, KD | 1 |
| Barnes, KM | 1 |
| Loriaux, DL | 1 |
| Cutler, GB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Spironolactone and Testolactone Treatment of Boys With Familial Isosexual Precocious Puberty[NCT00001202] | Phase 2 | 80 participants | Interventional | 1985-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for spironolactone and Aggression
| Article | Year |
|---|---|
Acute and lasting effects of single mineralocorticoid antagonism on offensive aggressive behaviour in rats.
Topics: Aggression; Animals; Male; Mineralocorticoid Receptor Antagonists; Rats; Spironolactone; Territorial | 2013 |
Mineralocorticoid receptor blockade during a rat's first violent encounter inhibits its subsequent propensity for violence.
Topics: Aggression; Animals; Electric Stimulation; Hypothalamus; Male; Mineralocorticoid Receptor Antagonist | 2013 |
Aggression in rainbow trout is inhibited by both MR and GR antagonists.
Topics: Aggression; Animals; Anti-Inflammatory Agents; Behavior, Animal; Drug Combinations; Enzyme Assays; H | 2009 |
Involvement of the lateral septum and the ventral Hippocampus in the emotional sequelae induced by social defeat: role of glucocorticoid receptors.
Topics: Aggression; Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Dominance-Subordina | 2007 |
Mineralocorticoid receptor blockade inhibits aggressive behaviour in male rats.
Topics: Aggression; Animals; Female; Male; Mineralocorticoid Receptor Antagonists; Rats; Rats, Wistar; Spiro | 1998 |
The active phase-related increase in corticosterone and aggression are linked.
Topics: Aggression; Animals; Behavior, Animal; Circadian Rhythm; Corticosterone; Darkness; Kinetics; Light; | 2000 |
Treatment of familial male precocious puberty with spironolactone and testolactone.
Topics: Aggression; Body Height; Child; Child, Preschool; Depression, Chemical; Drug Administration Schedule | 1989 |