spironolactone has been researched along with Adverse Drug Event in 19 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results revealed that metformin combined with spironolactone significantly reduced BMI and TT, but that it exerted no significant effects on hirsutism score, or on FSH or LH concentrations." | 9.41 | Metformin combined with spironolactone vs. metformin alone in polycystic ovary syndrome: a meta-analysis. ( Huang, L; Huang, S; Ren, W; Wu, J; Ye, Y; Zeng, H; Zhang, Y; Zhou, L, 2023) |
| "Eplerenone has been demonstrated as being cost effective for the treatment of patients with systolic heart failure (HF) and mild symptoms in several jurisdictions; however, its cost effectiveness is unknown in the context of Alberta, Canada." | 7.83 | Cost Effectiveness of Eplerenone for the Treatment of Systolic Heart Failure with Mild Symptoms in Alberta, Canada. ( Ezekowitz, JA; Kaul, P; Thanh, NX; Tran, DT, 2016) |
| "Our results revealed that metformin combined with spironolactone significantly reduced BMI and TT, but that it exerted no significant effects on hirsutism score, or on FSH or LH concentrations." | 5.41 | Metformin combined with spironolactone vs. metformin alone in polycystic ovary syndrome: a meta-analysis. ( Huang, L; Huang, S; Ren, W; Wu, J; Ye, Y; Zeng, H; Zhang, Y; Zhou, L, 2023) |
| "Eplerenone has been demonstrated as being cost effective for the treatment of patients with systolic heart failure (HF) and mild symptoms in several jurisdictions; however, its cost effectiveness is unknown in the context of Alberta, Canada." | 3.83 | Cost Effectiveness of Eplerenone for the Treatment of Systolic Heart Failure with Mild Symptoms in Alberta, Canada. ( Ezekowitz, JA; Kaul, P; Thanh, NX; Tran, DT, 2016) |
| "Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female." | 2.61 | Hirsutism in Women. ( Bain, J; Matheson, E, 2019) |
| "Medroxyprogesterone acetate (MPA) is a widely used progestin in feminizing hormone therapy." | 1.51 | Medroxyprogesterone Acetate in Gender-Affirming Therapy for Transwomen: Results From a Retrospective Study. ( Forcier, M; Jain, J; Kwan, D, 2019) |
| "Presumptive treatment for hyperkalemia was started based on her initial electrocardiogram." | 1.39 | Life-threatening hyperkalemia: a potentially lethal drug combination. ( Gourineni, VC; Juvet, T; Ravi, S; Zarich, SW, 2013) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " This increase was most likely caused by an increase in use of spironolactone combined with renin-angiotensin-aldosterone system inhibitors." | 1.35 | Increasing exposure to drug-drug interactions between 1992 and 2005 in people aged > or = 55 years. ( Becker, ML; Hofman, A; Stricker, BH; van Gelder, T; Visser, LE, 2008) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Zeng, H | 1 |
| Zhang, Y | 1 |
| Huang, S | 1 |
| Wu, J | 1 |
| Ren, W | 1 |
| Zhou, L | 1 |
| Huang, L | 1 |
| Ye, Y | 1 |
| Martin-Lorenzo, M | 1 |
| Martinez, PJ | 1 |
| Baldan-Martin, M | 1 |
| Ruiz-Hurtado, G | 1 |
| Prado, JC | 1 |
| Segura, J | 1 |
| de la Cuesta, F | 1 |
| Barderas, MG | 1 |
| Vivanco, F | 1 |
| Ruilope, LM | 1 |
| Alvarez-Llamas, G | 1 |
| Dhondt, B | 1 |
| Buelens, S | 1 |
| Van Besien, J | 1 |
| Beysens, M | 1 |
| De Bleser, E | 1 |
| Ost, P | 1 |
| Lumen, N | 1 |
| Jain, J | 1 |
| Kwan, D | 1 |
| Forcier, M | 1 |
| Matheson, E | 1 |
| Bain, J | 1 |
| Salavastru, CM | 1 |
| Fritz, K | 1 |
| Tiplica, GS | 1 |
| Juvet, T | 1 |
| Gourineni, VC | 1 |
| Ravi, S | 1 |
| Zarich, SW | 1 |
| Otero, MJ | 1 |
| Moreno-Gómez, AM | 1 |
| Santos-Ramos, B | 1 |
| Agra, Y | 1 |
| Hsu, WT | 1 |
| Shen, LJ | 1 |
| Lee, CM | 1 |
| Thanh, NX | 1 |
| Ezekowitz, JA | 1 |
| Tran, DT | 1 |
| Kaul, P | 1 |
| Becker, ML | 1 |
| Visser, LE | 1 |
| van Gelder, T | 1 |
| Hofman, A | 1 |
| Stricker, BH | 1 |
| Neumann, F | 1 |
| Daniele, E | 1 |
| De Nardo, D | 1 |
| Lawson, DH | 1 |
| Hutcheon, AW | 1 |
| Jick, H | 1 |
| Bossone, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Transversal, Multicentric Study for Early Detection of Drug Interactions in Older Hospitalized Patients Using on Line Software in Córdoba, Argentina[NCT00850330] | 3,000 participants (Anticipated) | Observational | 2009-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for spironolactone and Adverse Drug Event
| Article | Year |
|---|---|
Metformin combined with spironolactone vs. metformin alone in polycystic ovary syndrome: a meta-analysis.
Topics: Drug-Related Side Effects and Adverse Reactions; Female; Follicle Stimulating Hormone, Human; Hirsut | 2023 |
Hirsutism in Women.
Topics: Adrenal Hyperplasia, Congenital; Androgen Antagonists; Antineoplastic Agents, Hormonal; Contraceptiv | 2019 |
[Report on the incidence and pathogenetic problems of drug-induced gastroduodenal lesions].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Drug-Related Side Effects and Adverse Reactions; Est | 1978 |
16 other studies available for spironolactone and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Citric Acid Metabolism in Resistant Hypertension: Underlying Mechanisms and Metabolic Prediction of Treatment Response.
Topics: Aged; Antihypertensive Agents; Chromatography, Liquid; Citric Acid; Drug Resistance; Drug-Related Si | 2017 |
Abiraterone and spironolactone in prostate cancer: a combination to avoid.
Topics: Abiraterone Acetate; Aged, 80 and over; Antineoplastic Agents; Bone Neoplasms; Contraindications, Dr | 2019 |
Medroxyprogesterone Acetate in Gender-Affirming Therapy for Transwomen: Results From a Retrospective Study.
Topics: Adult; Breast; Drug-Related Side Effects and Adverse Reactions; Estradiol; Estrogens; Female; Hair; | 2019 |
[Spironolactone in dermatological treatment. On and off label indications].
Topics: Chronic Disease; Dermatologic Agents; Dose-Response Relationship, Drug; Drug-Related Side Effects an | 2013 |
Life-threatening hyperkalemia: a potentially lethal drug combination.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Diuretics; Drug-Related Side Effects and Adverse Reaction | 2013 |
Developing a list of high-alert medications for patients with chronic diseases.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Amiodarone; Analgesics, Opioid; Anti-Arrhythmi | 2014 |
Drug-related problems vary with medication category and treatment duration in Taiwanese heart failure outpatients receiving case management.
Topics: Adrenergic beta-Antagonists; Aged; Ambulatory Care; Angiotensin-Converting Enzyme Inhibitors; Case M | 2016 |
Cost Effectiveness of Eplerenone for the Treatment of Systolic Heart Failure with Mild Symptoms in Alberta, Canada.
Topics: Aged; Aged, 80 and over; Alberta; Cost-Benefit Analysis; Drug Costs; Drug-Related Side Effects and A | 2016 |
Increasing exposure to drug-drug interactions between 1992 and 2005 in people aged > or = 55 years.
Topics: Age Factors; Aged; Aged, 80 and over; Cohort Studies; Drug Interactions; Drug-Related Side Effects a | 2008 |
Effects of drugs and chemicals on spermatogenesis.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Male; Organ Size; Rats; Spermatogenesis; S | 1984 |
Life threatening drug reactions amongst medical in-patients.
Topics: Aged; Arrhythmias, Cardiac; Bethanidine; Digoxin; Drug-Related Side Effects and Adverse Reactions; F | 1979 |
The liver: a pharmacologic perspective.
Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec | 1977 |