spironolactone has been researched along with Adrenocortical Hyperfunction in 15 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Adrenocortical Hyperfunction: Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Plasma 18-hydroxycorticosterone (180HB) concentration was measured in 23 patients with primary aldosteronism." | 7.66 | The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism. ( Biglieri, EG; Schambelan, M, 1979) |
| "In untreated patients with primary aldosteronism caused either by adrenal adenoma or hyperplasia plasma aldosterone and cortisol concentrations fluctuated in unison and dexamethasone reduced both hormones markedly." | 5.26 | Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration. ( Ganguly, A; Luetscher, JA; Weinberger, MH, 1982) |
| "Twenty patients suffering from primary hyperaldosteronism were studied." | 5.26 | [The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism]. ( Benguigui, L; Corvol, P; Houde, M; Menard, J; Milliez, P; Tonnelier, M, 1977) |
| " Hypertension, hypokalaemia, hyperaldosteronism and renin suppression were corrected by unilateral adrenalectomy in 3/5 patients and by spironolactone treatment in 2/5." | 3.67 | Primary aldosteronism is comprised of primary adrenal hyperplasia and adenoma. ( Arteaga, EE; Biglieri, EG; Kater, CE, 1984) |
| "Plasma 18-hydroxycorticosterone (180HB) concentration was measured in 23 patients with primary aldosteronism." | 3.66 | The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism. ( Biglieri, EG; Schambelan, M, 1979) |
| "In untreated patients with primary aldosteronism caused either by adrenal adenoma or hyperplasia plasma aldosterone and cortisol concentrations fluctuated in unison and dexamethasone reduced both hormones markedly." | 1.26 | Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration. ( Ganguly, A; Luetscher, JA; Weinberger, MH, 1982) |
| "Twenty patients suffering from primary hyperaldosteronism were studied." | 1.26 | [The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism]. ( Benguigui, L; Corvol, P; Houde, M; Menard, J; Milliez, P; Tonnelier, M, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riester, A | 1 |
| Reincke, M | 1 |
| Beuschlein, F | 1 |
| GEOKAS, MC | 1 |
| CHUN, JY | 1 |
| DINAN, JJ | 1 |
| BECK, IT | 1 |
| Ganguly, A | 1 |
| Luetscher, JA | 1 |
| Weinberger, MH | 1 |
| Biglieri, EG | 2 |
| Kater, CE | 1 |
| Arteaga, EE | 1 |
| Aron, DC | 1 |
| Tyrrell, JB | 1 |
| Fitzgerald, PA | 1 |
| Findling, JW | 1 |
| Forsham, PH | 1 |
| Garagezova, AR | 1 |
| Kalinin, AP | 1 |
| Luk'ianchikov, VS | 1 |
| Schambelan, M | 1 |
| Corvol, P | 1 |
| Houde, M | 1 |
| Benguigui, L | 1 |
| Tonnelier, M | 1 |
| Menard, J | 1 |
| Milliez, P | 1 |
| Schrub, JC | 1 |
| Courtois, H | 1 |
| Morris, DV | 1 |
| Richards, P | 1 |
| Kremer, D | 1 |
| Beevers, DG | 1 |
| Brown, JJ | 1 |
| Davies, DL | 1 |
| Ferriss, JB | 1 |
| Fraser, R | 1 |
| Lever, AF | 1 |
| Robertson, JI | 1 |
| Kaplan, NN | 1 |
| Mannix, H | 1 |
| Liddle, GW | 1 |
| Carey, RM | 1 |
| Douglas, JG | 1 |
5 reviews available for spironolactone and Adrenocortical Hyperfunction
| Article | Year |
|---|---|
[Primary hyperaldosteronism: boundaries of diagnostics and therapy].
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Adrenocortical Hyperfunction; Aldos | 2014 |
[Diagnosis and treatment of mineral corticism].
Topics: Adrenal Cortex; Adrenal Cortex Function Tests; Adrenalectomy; Adrenocortical Hyperfunction; Antihype | 2000 |
Hirsutism.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Androgens; Cimetidine | 1985 |
Adrenal causes of hypertension.
Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Carci | 1974 |
Current management of primary hyperaldosteronism.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Angiography; Humans; Hyperaldosteron | 1974 |
10 other studies available for spironolactone and Adrenocortical Hyperfunction
| Article | Year |
|---|---|
ISLET-CELL CARCINOMA (ZOLLINGER-ELLISON SYNDROME) WITH FULMINATING ADRENOCORTICAL HYPERFUNCTION AND HYPOKALEMIA.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenalectomy; Adrenocortical Hyper | 1965 |
Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldoste | 1982 |
Primary aldosteronism is comprised of primary adrenal hyperplasia and adenoma.
Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Ag | 1984 |
Cushing's syndrome: problems in diagnosis.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult; | 1981 |
The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism.
Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aldosteron | 1979 |
[The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism].
Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Adult; Aldosterone; Blo | 1977 |
[Letter: Idiopathic hemochromatosis and Cushing's disease].
Topics: Adrenocortical Hyperfunction; Adult; Cushing Syndrome; Female; Hemochromatosis; Humans; Mitotane; Sp | 1975 |
Clinical investigation of the effects of adrenal corticosteroid excess on the colon.
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adult; Aldosterone; Colon; C | 1969 |
Spironolactone and amiloride in the treatment of low renin hyperaldosteronism and related syndromes.
Topics: Adrenocortical Hyperfunction; Amiloride; Angiotensin II; Body Water; Corticosterone; Diuretics; Extr | 1973 |
Role of the adrenal cortex in hypertension.
Topics: Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Humans; Hyperaldosteronism; Hypertensio | 1973 |