spironolactone has been researched along with Adrenal Hyperplasia, Congenital in 19 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the diuretic spironolactone cross reacts with 17alpha-hydroxyprogesterone (17OHP) in an enzyme linked immunosorbent assay (ELISA) kit used for the mass screening of congenital adrenal hyperplasia." | 7.70 | Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia. ( Arai, J; Ichihara, N; Kobayashi, K; Terai, I; Yamano, K, 1999) |
| "To determine if the diuretic spironolactone cross reacts with 17alpha-hydroxyprogesterone (17OHP) in an enzyme linked immunosorbent assay (ELISA) kit used for the mass screening of congenital adrenal hyperplasia." | 3.70 | Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia. ( Arai, J; Ichihara, N; Kobayashi, K; Terai, I; Yamano, K, 1999) |
| "Hirsutism is the excessive growth of terminal hair in a typical male pattern in a female." | 2.61 | Hirsutism in Women. ( Bain, J; Matheson, E, 2019) |
| "Primary hyperaldosteronism (PHA) is characterized by an increased Aldosterone synthesis which is independent of the Renin-Angiotensin-Aldosterone-System (RAAS)." | 2.48 | [Primay hyperaldosteronism--diagnostic and treatment]. ( Beuschlein, F; Potthoff, SA; Vonend, O, 2012) |
| "Hirsutism is defined as excess hair growth in androgen-dependent areas of the body in women." | 2.46 | Hirsutism: Diagnosis and management. ( Brodell, LA; Mercurio, MG, 2010) |
| "The prevalence of primary hyperaldosteronism is 5-10% of all hypertensive patients, and clearly above the estimated prevalence in the past." | 2.43 | [Modern pharmacological aspects of hyperaldosteronism therapy]. ( Quinkler, M; Reincke, M, 2006) |
| "Among 154 cases of primary aldosteronism seen in the General Clinical Research Center at San Francisco General Hospital, twelve patients did not fulfill established characteristics of an aldosterone producing adenoma (APA) or idiopathic hyperaldosteronism (IHA)." | 2.38 | Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma. ( Biglieri, EG; Irony, I; Kater, CE; Shackleton, CH, 1990) |
| "A 19 yr-old female patient with the diagnosis of late onset adrenal hyperplasia was treated since age 15 with different glucocorticoid preparations and dosage schedules plus spironolactone." | 1.28 | [Adrenal hyperplasia of late onset: optimization of therapy by measuring the circadian variation of serum 17-OH-progesterone]. ( Contreras, P; Rojas, A; Vega, I, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Azarchi, S | 1 |
| Bienenfeld, A | 1 |
| Lo Sicco, K | 1 |
| Marchbein, S | 1 |
| Shapiro, J | 1 |
| Nagler, AR | 1 |
| Matheson, E | 1 |
| Bain, J | 1 |
| Brodell, LA | 1 |
| Mercurio, MG | 2 |
| Potthoff, SA | 1 |
| Beuschlein, F | 1 |
| Vonend, O | 1 |
| Schroeder, BM | 1 |
| Okamoto, T | 1 |
| Minami, K | 1 |
| Narumi, S | 1 |
| Hasegawa, T | 1 |
| Quinkler, M | 1 |
| Reincke, M | 1 |
| Braithwaite, SS | 1 |
| Jabamoni, R | 1 |
| De Pedrini, P | 1 |
| Suraci, C | 1 |
| Costa, C | 1 |
| Raj, SG | 1 |
| Talbert, LM | 1 |
| Schalekamp, MA | 1 |
| Wenting, GJ | 1 |
| Man in 't Veld, AJ | 1 |
| Merke, DP | 1 |
| Cutler, GB | 1 |
| Terai, I | 1 |
| Yamano, K | 1 |
| Ichihara, N | 1 |
| Arai, J | 1 |
| Kobayashi, K | 1 |
| Saruta, T | 1 |
| Irony, I | 1 |
| Kater, CE | 1 |
| Biglieri, EG | 1 |
| Shackleton, CH | 1 |
| Contreras, P | 1 |
| Rojas, A | 1 |
| Vega, I | 1 |
| Morris, DV | 1 |
12 reviews available for spironolactone and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Androgens in women: Hormone-modulating therapies for skin disease.
Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Adrenal Hyperplasia, Congenital; Alopecia; Androgen Ant | 2019 |
Hirsutism in Women.
Topics: Adrenal Hyperplasia, Congenital; Androgen Antagonists; Antineoplastic Agents, Hormonal; Contraceptiv | 2019 |
Hirsutism: Diagnosis and management.
Topics: 5-alpha Reductase Inhibitors; Adrenal Hyperplasia, Congenital; Causality; Contraceptives, Oral; Diag | 2010 |
[Primay hyperaldosteronism--diagnostic and treatment].
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Adenoma; A | 2012 |
[11Beta-hydroxylase deficiency].
Topics: Adrenal Hyperplasia, Congenital; Dexamethasone; Diagnosis, Differential; Fetal Therapies; Glucocorti | 2006 |
[Modern pharmacological aspects of hyperaldosteronism therapy].
Topics: Adrenal Hyperplasia, Congenital; Adrenalectomy; Adrenocortical Adenoma; Angiotensin II Type 1 Recept | 2006 |
Hirsutism.
Topics: 17-Ketosteroids; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Androgen Antagonists; And | 1983 |
Polycystic ovarian disease.
Topics: Adrenal Hyperplasia, Congenital; Androgens; Chorionic Gonadotropin; Cimetidine; Clomiphene; Contrace | 1984 |
Pathogenesis of mineralocorticoid hypertension.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Aldosterone; Animals; Bloo | 1981 |
Hirsutism: diagnosis and management.
Topics: Adrenal Hyperplasia, Congenital; Androgens; Contraceptives, Oral; Eflornithine; Enzyme Inhibitors; F | 2001 |
Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma.
Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal | 1990 |
Hirsutism.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Androgens; Cimetidine | 1985 |
7 other studies available for spironolactone and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
ACOG releases guidelines on diagnosis and management of polycystic ovary syndrome.
Topics: Adrenal Hyperplasia, Congenital; Contraceptives, Oral; Diabetes Mellitus, Type 2; Female; Humans; Mi | 2003 |
Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency.
Topics: Adrenal Hyperplasia, Congenital; Anesthesia, Epidural; Anesthetics, Inhalation; Anesthetics, Intrave | 2003 |
[Therapy of female hirsutism: current status and new findings].
Topics: Adrenal Cortex Hormones; Adrenal Hyperplasia, Congenital; Androgen Antagonists; Androgens; Bromocrip | 1983 |
New approaches to the treatment of congenital adrenal hyperplasia.
Topics: Adrenal Hyperplasia, Congenital; Age Determination by Skeleton; Androgen Antagonists; Child; Cyprote | 1997 |
Influence of spironolactone on neonatal screening for congenital adrenal hyperplasia.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Diuretics; Enzyme-Linked Immunosorben | 1999 |
[Aldosteronism and the related diseases].
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Calcium Channel Blockers; Female; Humans; Hypera | 1992 |
[Adrenal hyperplasia of late onset: optimization of therapy by measuring the circadian variation of serum 17-OH-progesterone].
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adult; Circadian Rhythm; Dexamethason | 1989 |