spironolactone has been researched along with Adrenal Gland Hypofunction in 14 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Five patients with primary aldosteronism due to adenoma were followed during spironolactone treatment, for 35-55 days after the drug had been stopped, and finally, after surgery." | 3.65 | Volume-pressure relationships during development of mineralocorticoid hypertension in man. ( Derkx, FH; Man in 't Veld, AJ; Schalekamp, DH; Verhoeven, RP; Wenting, GH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, K | 1 |
| Ou, X | 1 |
| Huang, X | 1 |
| Lan, Q | 1 |
| Vogt, S | 1 |
| Winkler, E | 1 |
| Hermsen, D | 1 |
| Schott, M | 1 |
| Schinner, S | 1 |
| Scherbaum, WA | 1 |
| Willenberg, HS | 1 |
| STEINMAN, AM | 1 |
| STUDER, H | 1 |
| GAUTIER, E | 1 |
| SCHMID, A | 1 |
| LAMBERG, BA | 1 |
| TORSTI, P | 1 |
| Puentes, F | 1 |
| Jackson, TW | 1 |
| Isales, CM | 1 |
| Skrabal, F | 1 |
| Rampini, S | 1 |
| Furrer, J | 1 |
| Keller, HP | 1 |
| Bucher, H | 1 |
| Zachmann, M | 1 |
| Wenting, GH | 1 |
| Man in 't Veld, AJ | 1 |
| Verhoeven, RP | 1 |
| Derkx, FH | 1 |
| Schalekamp, DH | 1 |
| Melby, JC | 1 |
| McGiff, JC | 1 |
| Muzzarelli, RE | 1 |
| Duffy, PA | 1 |
| Gonzalez, Y | 1 |
| Pierce, CE | 1 |
| Frawley, TF | 1 |
| Vallotton, MB | 1 |
| Scholer, D | 1 |
| Muller, AF | 1 |
| Dunihue, FW | 1 |
| Bauer, HJ | 1 |
1 review available for spironolactone and Adrenal Gland Hypofunction
| Article | Year |
|---|---|
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldoster | 1971 |
13 other studies available for spironolactone and Adrenal Gland Hypofunction
| Article | Year |
|---|---|
Adrenocortical hypofunction with simultaneous primary aldosteronism: A case report.
Topics: Adrenal Insufficiency; Aged; Aldosterone; Cushing Syndrome; Female; Humans; Hydrocortisone; Hyperald | 2019 |
Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone.
Topics: Adrenal Insufficiency; Adrenomedullin; Adult; Anti-Inflammatory Agents; Biomarkers; Dexamethasone; D | 2012 |
Mechanism of action and use of aldosterone-blocking steroids in edema.
Topics: Addison Disease; Adrenal Insufficiency; Aldosterone; Edema; Humans; Hypoadrenocorticism, Familial; S | 1962 |
[THE EFFECT OF MINERALOCORTICOIDS ON THE DILUTION AND CONCENTRATION MECHANISMS OF THE KIDNEY].
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Humans; Hypoadrenoco | 1964 |
THE DEPENDENCE OF CALCIUM EXCRETION ON ADRENAL STEROIDS. STUDIES WITH CHLOROTHIAZIDE IN PATIENTS WITH IMPAIRED ADRENAL FUNCTION.
Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Blo | 1964 |
A patient with concurrent primary hyperaldosteronism and adrenal insufficiency.
Topics: Adrenal Insufficiency; Aged; Humans; Hyperaldosteronism; Male; Mineralocorticoid Receptor Antagonist | 2004 |
[An adrenal function test for general practice. Diagnosis of adrenal cortex insufficiency and primary and secondary hyperaldosteronism].
Topics: Adrenal Cortex Function Tests; Adrenal Insufficiency; Cosyntropin; Humans; Hyperaldosteronism; Hyper | 1981 |
Congenital pseudohypoaldosteronism: case report and review. Effect of indomethacin during sodium chloride depletion.
Topics: Adrenal Insufficiency; Aldosterone; Body Weight; Chlorides; Desoxycorticosterone; Diagnosis, Differe | 1978 |
Volume-pressure relationships during development of mineralocorticoid hypertension in man.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Insufficiency; Blood Pressure; Blood Volume; Electrolytes; | 1977 |
Interrelationships of renin and aldosterone in a patient with hypoaldosteronism.
Topics: Adrenal Insufficiency; Aged; Aldosterone; Angiotensin II; Diet; Diet, Sodium-Restricted; Female; Hum | 1970 |
[The renin-angiotensin-aldosterone system. Disorders and methods of clinical research].
Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Aldosterone; Angiotensin II; Dexamethasone; Electrol | 1970 |
Reversal of the reduced juxtaglomerular cell granularity (GCI) in old rats.
Topics: Adrenal Insufficiency; Adrenalectomy; Aging; Animals; Cortisone; Female; Juxtaglomerular Apparatus; | 1971 |
[Periodic paralyses].
Topics: Adrenal Insufficiency; Adult; Humans; Hyperaldosteronism; Hyperthyroidism; Hypokalemia; Male; Muscle | 1967 |