Compounds > spironolactone
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spironolactone and Adrenal Gland Diseases

spironolactone has been researched along with Adrenal Gland Diseases in 26 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Adrenal Gland Diseases: Pathological processes of the ADRENAL GLANDS.

Research Excerpts

ExcerptRelevanceReference
"Sixty-four patients with primary aldosteronism were included in the study."1.33Diurnal blood pressure pattern in patients with primary aldosteronism. ( Elenkova, A; Kalinov, K; Nachev, E; Orbetzova, M; Schigarminova, R; Stoynev, A; Yaneva, M; Zacharieva, S, 2006)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199022 (84.62)18.7374
1990's3 (11.54)18.2507
2000's1 (3.85)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SLATON, PE1
BIGLIERI, EG1
Zacharieva, S1
Orbetzova, M1
Elenkova, A1
Stoynev, A1
Yaneva, M1
Schigarminova, R1
Kalinov, K1
Nachev, E1
Davis, WW1
Newsome, HH1
Wright, LD1
Hammond, WG1
Easton, J1
Bartter, FC1
Malchoff, CD1
Malchoff, DM1
Reardon, G1
Hofmockel, G1
Heimbach, D1
Bussen, D1
Reincke, M1
Frohmüller, HG1
Drozdova, ES1
Kaesemeyer, WH1
Prisant, LM1
Carr, AA1
Ferriss, JB2
Brown, JJ2
Fraser, R2
Kay, AW1
Neville, AM1
O'Muircheartaigh, IG1
Robertson, JI2
Symington, T1
Lever, AF2
Somogyi, A4
Kovacs, K4
Solymoss, B1
Kuntzman, R1
Conney, AH1
Lurie, AO2
Goodman, AD1
Vagnucci, AH1
Hartroft, PM1
Horton, R1
Beevers, DG1
Kaplan, NN1
Bordás, E1
Bretter, E1
Lazar, G2
Szabo, S2
Husztik, E1
Distler, A1
Just, HJ1
Philipp, T1
Fournier, A1
Hofmann, LM1
Sagartz, JW1
Albeaux-Fernet, M1
Bellot, L1
Canet, L1
Deribreux, J1
Gelinet, M1
Ross, EJ1

Reviews

3 reviews available for spironolactone and Adrenal Gland Diseases

ArticleYear
Aldosterone: review of its physiology and diagnostic aspects of primary aldosteronism.
    Metabolism: clinical and experimental, 1973, Volume: 22, Issue:12

    Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone;

1973
The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess.
    American heart journal, 1973, Volume: 86, Issue:3

    Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Antihypertensive Agents; Carc

1973
Adrenal causes of hypertension.
    Archives of internal medicine, 1974, Volume: 133, Issue:6

    Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Carci

1974

Other Studies

23 other studies available for spironolactone and Adrenal Gland Diseases

ArticleYear
HYPERTENSION AND HYPERALDOSTERONISM OF RENAL AND ADRENAL ORIGIN.
    The American journal of medicine, 1965, Volume: 38

    Topics: Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Blood; Child; Diagnosis,

1965
Diurnal blood pressure pattern in patients with primary aldosteronism.
    Journal of endocrinological investigation, 2006, Volume: 29, Issue:1

    Topics: Adenoma; Adrenal Gland Diseases; Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circa

2006
Bilateral adrenal hyperplasia as a cause of primary aldosteronism with hypertension, hypokalemia and suppressed renin activity.
    The American journal of medicine, 1967, Volume: 42, Issue:4

    Topics: 17-Hydroxycorticosteroids; Adrenal Gland Diseases; Adrenal Glands; Aldosterone; Blood Urea Nitrogen;

1967
Glucocorticoid resistance.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Adrenal Gland Diseases; Amiloride; Child; Dexamethasone; Drug Resistance; Flutamide; Glucocorticoids

1994
[Surgical interventions of the adrenal gland. Diagnosis and results of treatment].
    Der Urologe. Ausg. A, 1994, Volume: 33, Issue:6

    Topics: Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Adenoma;

1994
[Disorder of the mineralocorticoid function of the adrenals in the acute period of myocardial infarct and the ways for its correction].
    Sovetskaia meditsina, 1979, Issue:1

    Topics: Acute Disease; Adrenal Gland Diseases; Adult; Aged; Aldosterone; Chronic Disease; Coronary Disease;

1979
Verapamil and nifedipine in combination for the treatment of hypertrophy heart disease.
    American journal of hypertension, 1991, Volume: 4, Issue:10 Pt 1

    Topics: Adrenal Gland Diseases; Blood Pressure; Cardiovascular Diseases; Drug Therapy, Combination; Humans;

1991
Hypertension with aldosterone excess and low plasma-renin: preoperative distinction between patients with and without adrenocortical tumour.
    Lancet (London, England), 1970, Nov-14, Volume: 2, Issue:7681

    Topics: Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Age Fac

1970
Suppression of 7,12-dimethylbenz( )anthracene-produced adrenal necrosis by steroids capable of inducing aryl hydrocarbon hydroxylase.
    Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1971, Nov-22, Volume: 10, Issue:22

    Topics: Adrenal Gland Diseases; Androstanes; Animals; Benz(a)Anthracenes; Benzopyrenes; Betamethasone; Dexam

1971
Spironolactone and steroid assay.
    Lancet (London, England), 1969, Aug-09, Volume: 2, Issue:7615

    Topics: Adrenal Gland Diseases; Humans; Hydrocortisone; Spironolactone

1969
Pathogenesis of Bartter's syndrome.
    The New England journal of medicine, 1969, Dec-25, Volume: 281, Issue:26

    Topics: Adrenal Gland Diseases; Adrenocorticotropic Hormone; Albumins; Aldosterone; Alkalosis; Angiotensin I

1969
[Effect of spironolactone in experimental myocardial necrosis].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Sep-01, Volume: 27, Issue:17

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Female; Heart Diseases; Hyperplasia; Male; Myocardi

1972
The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1972, Volume: 159, Issue:1

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Chemical and Drug Induced Liver Injury; Ethylestren

1972
Effect of hypophysectomy and catatoxic steroids on thioacetamide-induced adrenal lesions in rats.
    Endokrinologie, 1973, Volume: 61, Issue:1

    Topics: Acetamides; Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Dexamethasone; Ethyles

1973
[Research on the pathogenesis of hypertension in primary hyperaldosteronism].
    Minerva medica, 1973, Aug-18, Volume: 64, Issue:58

    Topics: Adrenal Gland Diseases; Animals; Hemodynamics; Hyperaldosteronism; Hyperplasia; Hypertension; Spiron

1973
[Primary hyperaldosteronism: differentiation between adenoma and primary hyperplasia of the adrenal glands and operative indications].
    La Presse medicale, 1971, Dec-18, Volume: 79, Issue:54

    Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Dexamethasone; Diagnosis, Dif

1971
Plasma cortisol assay. Interference by spironolactone.
    JAMA, 1970, Mar-16, Volume: 211, Issue:11

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Diseases; Fluorometry; Humans; Hydrocortis

1970
Effects of hydrochlorothiazide, spironolactone and metyrapone on electrolyte excretion and zona glomerulosa width in the sodium depleted rat.
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 185, Issue:1

    Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenal Medulla; Animals; Diet, Sodium-Restricted; Hydrochlo

1970
[Inhibitors of adreno-cortical hormone synthesis].
    L'Annee endocrinologique, 1970, Volume: 22

    Topics: Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Glands; Dichlorodiphenyldichloroethane; Hum

1970
Inhibition by spironolactone of 7-hydroxymethyl-12-methylbenz(a)anthracene-induced adrenal necrosis in rats.
    Endokrinologie, 1970, Volume: 56, Issue:2

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Female; Necrosis; Rats; Spirono

1970
Effect of various steroids on the adrenal necrosis induced by 7,12-dimethylbenz(a)anthracene in rats.
    Revue canadienne de biologie, 1970, Volume: 29, Issue:2

    Topics: Adrenal Gland Diseases; Adrenal Glands; Anabolic Agents; Animals; Benz(a)Anthracenes; Desoxycorticos

1970
Prevention by spironolactone of 7,12-dimethylbenz(a)anthracene-induced adrenal necrosis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 131, Issue:4

    Topics: Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Female; Hemorrhage; Necrosis; Rats; Spironolact

1969
Conn's syndrome due to adrenal hyperplasia with hypertrophy of zona glomerulosa, relieved by unilateral adrenalectomy.
    The American journal of medicine, 1965, Volume: 39, Issue:6

    Topics: Adrenal Gland Diseases; Adrenalectomy; Adult; Alkalosis; Humans; Hydrocortisone; Hyperaldosteronism;

1965