spironolactone has been researched along with Adjuvant Arthritis in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with spironolactone, pregnenolone-16_-carbonitrile or triamcinolone reduced only slightly SGPT and triglycerides, but restored the reduced resistance to drugs, and the impairment of the liver drug metabolism in vitro." | 1.28 | Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents. ( Kourounakis, PN; Rekka, E, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kourounakis, PN | 1 |
| Rekka, E | 1 |
1 other study available for spironolactone and Adjuvant Arthritis
| Article | Year |
|---|---|
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
Topics: Alanine Transaminase; Animals; Arthritis, Experimental; Chemical and Drug Induced Liver Injury; Fema | 1991 |