spironolactone and Adenoma studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Research Excerpts

Excerpt	Relevance	Reference
"Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas."	7.68	Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism. ( Ichikawa, S; Murata, K; Nakamura, T; Ono, Z; Sakamaki, T; Sakamoto, H; Takayama, Y, 1990)
"A case of primary aldosteronism treated with spironolactone therapy has been followed up for 24 years."	7.68	Twenty-four year spironolactone therapy in an aged patient with aldosterone-producing adenoma. ( Hashimoto, T; Ito, Y; Koshida, H; Miyamori, I; Morimoto, S; Morise, T; Takeda, R; Yamazaki, T, 1992)
"Aldosterone-producing adenomas in patients who have not been given spironolactone are more responsive to ACTH than to angiotensin II."	7.67	In vitro responses of aldosterone-producing adenomas to angiotensin II and ACTH after treatment with spironolactone before adrenalectomy. ( Wisgerhof, M, 1984)
"Plasma 18-hydroxycorticosterone (180HB) concentration was measured in 23 patients with primary aldosteronism."	7.66	The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism. ( Biglieri, EG; Schambelan, M, 1979)
"So-called Spironolactone bodies are reported in four adrenal cortical adenomas that were removed from patients with primary hyperaldosteronism, treated preoperatively with spironolactone."	7.66	[Spironolactone bodies. Light and electron microscope study apropos of 4 cases of adrenal adenomas with primary hyperaldosteronism]. ( Abelanet, R; Daudet-Monsac, M; Lellouch-Tubiana, A; Louvel, A; Vacher-Lavenu, MC, 1982)
"The effect of prolonged preoperative treatment with spironolactone has been studied in a series of 67 patients with hypertension, aldosterone excess, and low plasma renin."	7.65	Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess, and low plasma renin. ( Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Haywood, E; Lever, AF; Robertson, JI, 1972)
"Spironolactone bodies were observed in an adrenal cortical adenoma that was removed from a patient with primary hyperaldosteronism (Conn syndrome) treated preoperatively with spironolactone."	7.65	Spironolactone bodies in an adrenal adenoma. ( Cooper, PH; Shrago, SS; Waisman, J, 1975)
"Twenty patients suffering from primary hyperaldosteronism were studied."	5.26	[The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism]. ( Benguigui, L; Corvol, P; Houde, M; Menard, J; Milliez, P; Tonnelier, M, 1977)
"In untreated patients with primary aldosteronism caused either by adrenal adenoma or hyperplasia plasma aldosterone and cortisol concentrations fluctuated in unison and dexamethasone reduced both hormones markedly."	5.26	Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration. ( Ganguly, A; Luetscher, JA; Weinberger, MH, 1982)
"In primary aldosteronism the type of adrenal lesion was correctly identified in 28 of 40 patients (70%) by standard adrenal scintigraphy."	5.26	Adrenal scintigraphy in primary aldosteronism. Spironolactone as a cause of incorrect classification between adenoma and hyperplasia. ( Fischer, M; Vetter, H; Vetter, W; Winterg, B; Zidek, W, 1982)
"Forty-two patients with confirmed primary aldosteronism (21 with aldosterone-producing adenoma treated by unilateral laparoscopic adrenalectomy, 21 treated with spironolactone) were investigated by carotid ultrasound at baseline and 1 and 6 years after the specific treatment."	3.81	Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness. ( Holaj, R; Indra, T; Michalský, D; Novák, K; Petrák, O; Rosa, J; Šomlóová, Z; Štrauch, B; Wichterle, D; Widimský, J; Zelinka, T, 2015)
"When performed with careful regard to confounding factors, measurement of the aldosterone : renin ratio in all hypertensive individuals, followed by fludrocortisone suppression testing to confirm or exclude primary aldosteronism and adrenal venous sampling to determine the subtype, can result in the detection of significant numbers of patients with specifically treatable or potentially curable hypertension."	3.72	High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients. ( Archibald, C; Cowley, DC; Gordon, RD; Gunasekera, TG; Smithers, BM; Stowasser, M; Ward, G, 2003)
" Five of these patients with aldosterone producing adenoma were operated on and four patients with idiopathic hyperaldosteronism were treated with spironolactone."	3.70	Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment. ( Haas, T; Hilgertová, J; Prázný, M; Sindelka, G; Skrha, J; Widimský, J, 2000)
"The study showed that the main determinants of a surgical cure of hypertension in primary aldosteronism were presence of adenoma and preoperative response to spironolactone."	3.69	Factors influencing outcome of surgery for primary aldosteronism. ( Beazley, RM; Celen, O; Melby, JC; O'Brien, MJ, 1996)
"Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas."	3.68	Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism. ( Ichikawa, S; Murata, K; Nakamura, T; Ono, Z; Sakamaki, T; Sakamoto, H; Takayama, Y, 1990)
"A case of primary aldosteronism treated with spironolactone therapy has been followed up for 24 years."	3.68	Twenty-four year spironolactone therapy in an aged patient with aldosterone-producing adenoma. ( Hashimoto, T; Ito, Y; Koshida, H; Miyamori, I; Morimoto, S; Morise, T; Takeda, R; Yamazaki, T, 1992)
"The prognosis of hypertension was evaluated pre-operatively in 40 patients with primary aldosteronism owing to adenoma by examining the severity of hypertension, family history of hypertension, age of the patients, duration of hypertension, plasma renin activity, plasma aldosterone concentration, and efficacy of spironolactone (100 mg per day for 10 days) on blood pressure."	3.67	Pre-operative evaluation of the prognosis of hypertension in primary aldosteronism owing to adenoma. ( Murai, M; Saito, I; Saruta, T; Suzuki, H; Takita, T; Tazaki, H, 1987)
"Aldosterone-producing adenomas in patients who have not been given spironolactone are more responsive to ACTH than to angiotensin II."	3.67	In vitro responses of aldosterone-producing adenomas to angiotensin II and ACTH after treatment with spironolactone before adrenalectomy. ( Wisgerhof, M, 1984)
" Hypertension, hypokalaemia, hyperaldosteronism and renin suppression were corrected by unilateral adrenalectomy in 3/5 patients and by spironolactone treatment in 2/5."	3.67	Primary aldosteronism is comprised of primary adrenal hyperplasia and adenoma. ( Arteaga, EE; Biglieri, EG; Kater, CE, 1984)
" Serum electrolytes became normal after spironolactone but not after dexamethasone."	3.66	Normotensive primary aldosteronism: report of a case. ( Ikeda, F; Imura, H; Kono, T; Oseko, F; Tanimura, H, 1981)
"So-called Spironolactone bodies are reported in four adrenal cortical adenomas that were removed from patients with primary hyperaldosteronism, treated preoperatively with spironolactone."	3.66	[Spironolactone bodies. Light and electron microscope study apropos of 4 cases of adrenal adenomas with primary hyperaldosteronism]. ( Abelanet, R; Daudet-Monsac, M; Lellouch-Tubiana, A; Louvel, A; Vacher-Lavenu, MC, 1982)
"Histological sections taken from aldosterone-producing-adenomas and from non-tumorous adrenal cortex of 18 patients treated for primary aldosteronism by unilateral adrenalectomy were examined for spironolactone inclusion bodies."	3.66	Factors affecting the frequency of occurrence of spironolactone bodies in aldosteronomas and non-tumorous cortex. ( Cohn, D; Gordon, RD; Jackson, RV, 1983)
"Plasma 18-hydroxycorticosterone (180HB) concentration was measured in 23 patients with primary aldosteronism."	3.66	The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism. ( Biglieri, EG; Schambelan, M, 1979)
" Our results show that both before and after a 9-months therapy with spironolactone episodic aldosterone release of an aldosterone producing adrenal adenoma was mediated through ACTH and that endogeneous angiotensin II had no or only little influence."	3.65	Control of plasma aldosterone in a patient with Conn's syndrome before and during spironolactone medication. ( Vetter, H; Vetter, W, 1975)
"Spironolactone bodies were observed in an adrenal cortical adenoma that was removed from a patient with primary hyperaldosteronism (Conn syndrome) treated preoperatively with spironolactone."	3.65	Spironolactone bodies in an adrenal adenoma. ( Cooper, PH; Shrago, SS; Waisman, J, 1975)
" Five patients with primary aldosteronism due to adenoma were followed during spironolactone treatment, for 35-55 days after the drug had been stopped, and finally, after surgery."	3.65	Volume-pressure relationships during development of mineralocorticoid hypertension in man. ( Derkx, FH; Man in 't Veld, AJ; Schalekamp, DH; Verhoeven, RP; Wenting, GH, 1977)
"Effects of spironolactone, canrenone and canrenoate-K on adrenal cytochrome P450 (P450) and corticosteroid biosynthesis were examined by studying difference spectra, P450 reduction and corticoid hydroxylation in mitochondrial preparations isolated from zona fasciculata and zona glomerulosa of bovine adrenals and from adrenal adenoma and hyperplastic adrenal cortex removed from patients with hyperaldosteronism."	3.65	Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. ( Cheng, SC; Harding, BW; Sadee, W; Suzuki, K, 1976)
"The effect of prolonged preoperative treatment with spironolactone has been studied in a series of 67 patients with hypertension, aldosterone excess, and low plasma renin."	3.65	Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess, and low plasma renin. ( Brown, JJ; Davies, DL; Ferriss, JB; Fraser, R; Haywood, E; Lever, AF; Robertson, JI, 1972)
"Primary hyperaldosteronism will be the most common etiology."	2.47	[Primary hyperaldosteronism]. ( Chambaz, IC; Pechère-Bertschi, A, 2011)
"Primary hyperaldosteronism is characterised by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion."	2.45	Rhabdomyolysis due to primary hyperaldosteronism. ( Corrales, PP; López, AH; Martínez, JJ; Meneses, AL; Oliveira, CL; Rodríguez, SA; Romero, FB, 2009)
"Primary aldosteronism is one of the few potentially curable forms of hypertension."	2.44	Primary aldosteronism. ( Auchus, RJ; Nwariaku, FE, 2007)
"Primary aldosteronism (PA) has been regarded for a long time as being a rare cause of arterial hypertension, but its prevalence has recently been reassessed as about 10%."	2.42	[Investigation of hyperaldosteronism in the hypertensive patient. Why? When? How?]. ( Amar, J; Chamontin, B; Herpin, D; Sosner, P, 2003)
"Among 154 cases of primary aldosteronism seen in the General Clinical Research Center at San Francisco General Hospital, twelve patients did not fulfill established characteristics of an aldosterone producing adenoma (APA) or idiopathic hyperaldosteronism (IHA)."	2.38	Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma. ( Biglieri, EG; Irony, I; Kater, CE; Shackleton, CH, 1990)
" Suitable techniques for the investigation of secondary aldosteronism of unknown cause and for primary and secondary hypoaldosteronism are described, as well as the adjustment of dosage for replacement therapy where mineralocorticoid secretion is deficient."	2.37	Disorders of mineralocorticoid activity. ( Drury, PL, 1985)
"Fifty-four patients with primary aldosteronism were enrolled in a prospective study and were followed for a mean of 6."	1.34	Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism. ( Catena, C; Chiuch, A; Colussi, G; Gianfagna, P; Lapenna, R; Nadalini, E; Sechi, LA, 2007)
"Primary hyperaldosteronism due to APA was associated with normal circadian BP variability and the surgical treatment led to highly significant decline in all BP parameters but had no influence on the extent of nocturnal BP variation."	1.33	Diurnal blood pressure pattern in patients with primary aldosteronism. ( Elenkova, A; Kalinov, K; Nachev, E; Orbetzova, M; Schigarminova, R; Stoynev, A; Yaneva, M; Zacharieva, S, 2006)
"Primary aldosteronism (Conn syndrome) is found in < 0."	1.31	[Secondary forms of hypertension. 5. Hypertension caused by Cushing syndrome and Conn's disease]. ( Füessl, HS, 2002)
"Since 1974 primary aldosteronism has been diagnosed in 71 patients in our outpatient clinic."	1.29	Primary aldosteronism: difference in clinical presentation and long-term follow-up between adenoma and bilateral hyperplasia of the adrenal glands. ( Erdmenger, L; Grüne, S; Jeck, T; Mengden, T; Vetter, W; Weisser, B, 1994)
"Twenty-eight patients with primary aldosteronism were treated from 1974 to 1990."	1.28	[Diagnosis and treatment of primary aldosteronism]. ( Wang, GY, 1992)
"Biological primary aldosteronism was found post-operatively in 2 of these 3 patients and also in one whose hypertension was improved."	1.27	[Results of the surgical treatment of Conn's adenomas]. ( Chatellier, G; Corvol, P; Duclos, JM; Ménard, J; Pagny, JY; Plouin, PF, 1987)
"Spironolactone was administered in 6 of these patients, but not in the remaining patient."	1.27	Ultrastructural studies of adrenal adenoma causing primary aldosteronism. ( Kumazawa, J; Kuramoto, H, 1985)
"Spironolactone was indicated preoperatively for all surgical candidates, for non-operated APA patients, and for all IHA patients."	1.26	Primary aldosteronism -- screening, diagnosis and therapy. ( Gregorová, I; Horký, K; Hradec, E; Silinková-Málková, E; Vancura, J, 1981)
"In primary aldosteronism the type of adrenal lesion was correctly identified in 28 of 40 patients (70%) by standard adrenal scintigraphy."	1.26	Adrenal scintigraphy in primary aldosteronism. Spironolactone as a cause of incorrect classification between adenoma and hyperplasia. ( Fischer, M; Vetter, H; Vetter, W; Winterg, B; Zidek, W, 1982)
"In untreated patients with primary aldosteronism caused either by adrenal adenoma or hyperplasia plasma aldosterone and cortisol concentrations fluctuated in unison and dexamethasone reduced both hormones markedly."	1.26	Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration. ( Ganguly, A; Luetscher, JA; Weinberger, MH, 1982)
"Twenty patients suffering from primary hyperaldosteronism were studied."	1.26	[The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism]. ( Benguigui, L; Corvol, P; Houde, M; Menard, J; Milliez, P; Tonnelier, M, 1977)
"An unusual case of primary aldosteronism with bilateral single adenomas is reported."	1.26	Primary aldosteronism with bilateral adrenal adenomas. ( Favre, L; Hauser, H; Jacot-des-Combes, E; Mégevand, R; Morel, P; Riondel, AM; Vallotton, MB, 1980)
"Hyperparathyroidism and hyperaldosteronism coexisted in association with medullary sponge kidneys in a 27-year-old woman with severe hypertension."	1.26	Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension. ( Hellman, DE; Kartchner, M; Komar, N; Mayes, D; Pitt, M, 1980)

Timeframe	Studies, this research(%)	All Research%
pre-1990	80 (72.73)	18.7374
1990's	12 (10.91)	18.2507
2000's	15 (13.64)	29.6817
2010's	2 (1.82)	24.3611
2020's	1 (0.91)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Aldosterone-Renin Ratio to Diagnose Primary Aldosteronism in a Population of Patients With Therapy-Resistant Hypertension: Test Characteristics, Diagnostic Value and Predictive Value for Antihypertensive Treatment. The Dutch ARRAT Study.[NCT00407784]	500 participants	Observational	2007-01-31	Recruiting
Characteristics Predicting Clinically Relevant Reduction of Hypertension Following Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis[NCT04761354]	514 participants (Actual)	Observational	2016-03-26	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Rhabdomyolysis due to primary hyperaldosteronism. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2009, Volume: 56, Issue:8 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Female; Humans; Hyperaldosteronism; Hyperten	2009
[Primary hyperaldosteronism]. Revue medicale suisse, 2011, Sep-14, Volume: 7, Issue:308 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Algorithms; Humans; Hyperaldosteronism; Hypertensi	2011
[Investigation of hyperaldosteronism in the hypertensive patient. Why? When? How?]. Archives des maladies du coeur et des vaisseaux, 2003, Volume: 96, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Age of Onset; Female; Humans; Hyperaldosteronism; Hypertens	2003
Clinical manifestation of aldosteronoma. The Surgical clinics of North America, 2004, Volume: 84, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Diagnosis, Differential; Humans; Hyperaldosteronism	2004
[Clinical characteristics of primary and secondary aldosteronism]. Nihon rinsho. Japanese journal of clinical medicine, 2006, May-28, Volume: Suppl 1 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Diagnosis, Differential; Drug Therapy, Combination; E	2006
[Corticosterone-producing adrenal tumor]. Nihon rinsho. Japanese journal of clinical medicine, 2006, May-28, Volume: Suppl 1 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Corticosterone; Diagnosis, Differential; Humans; Hy	2006
Primary aldosteronism. Current cardiology reports, 2007, Volume: 9, Issue:6 Topics: Adenoma; Heart Failure; Humans; Hyperaldosteronism; Mass Screening; Mineralocorticoid Receptor Antag	2007
Primary hyperaldosteronism. Pharmacology & therapeutics, 1980, Volume: 9, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Amiloride; Diagnosis, Differential; F	1980
Primary aldosteronism--a review. Urological survey, 1980, Volume: 30, Issue:4 Topics: 18-Hydroxycorticosterone; Adenoma; Adolescent; Adrenal Glands; Adult; Aldosterone; Child; Humans; Hy	1980
Pathogenesis of mineralocorticoid hypertension. Clinics in endocrinology and metabolism, 1981, Volume: 10, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adult; Aldosterone; Animals; Bloo	1981
[Primary hyperaldosteronism]. La Revue du praticien, 1998, Apr-01, Volume: 48, Issue:7 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Aldosterone; Algorithms; Amiloride; Di	1998
Abnormal regulation of aldosterone in hypertension. Advances in internal medicine, 1975, Volume: 20 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Circadian Rhythm; Diures	1975
Primary aldosteronism. The Urologic clinics of North America, 1977, Volume: 4, Issue:2 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aldosterone; Humans; Hyperaldosteronism;	1977
[Primary aldosteronism--aldosterone-induced sodium storing hypertension--symptoms and differential diagnosis]. Nihon rinsho. Japanese journal of clinical medicine, 1979, Volume: 37, Issue:2 Topics: Adenoma; Adrenal Cortex Neoplasms; Aldosterone; Alkalosis; Animals; Diagnosis, Differential; Dogs; F	1979
Correctable subsets of primary aldosteronism. Primary adrenal hyperplasia and renin responsive adenoma. American journal of hypertension, 1990, Volume: 3, Issue:7 Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenal	1990
Disorders of mineralocorticoid activity. Clinics in endocrinology and metabolism, 1985, Volume: 14, Issue:1 Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Glands; Adult; Aldosterone; Angiotensin II; Blood Specime	1985
Aldosterone: review of its physiology and diagnostic aspects of primary aldosteronism. Metabolism: clinical and experimental, 1973, Volume: 22, Issue:12 Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone;	1973
Aldosteronism updated. The Journal of urology, 1973, Volume: 110, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Blood Pressure; Dexamethasone; Diagnosis, Differentia	1973
The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess. American heart journal, 1973, Volume: 86, Issue:3 Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Antihypertensive Agents; Carc	1973
Adrenal causes of hypertension. Archives of internal medicine, 1974, Volume: 133, Issue:6 Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adult; Carci	1974
[Present trends in the diagnosis of primary hyperaldosteronism]. Giornale italiano di cardiologia, 1974, Volume: 4, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Desoxycorticosterone; Humans; Hyperaldosteronism; Pot	1974
Current management of primary hyperaldosteronism. Connecticut medicine, 1974, Volume: 38, Issue:12 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Angiography; Humans; Hyperaldosteron	1974
Commentary on incidence of primary aldosteronism: current estimations based on objective data. Archives of internal medicine, 1969, Volume: 123, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Blood Pressure; Desoxycorticosterone;	1969

Article	Year
Unique Case of Cardiomyopathy Secondary to Adrenal Adenoma (Primary-Aldosteronism). The Journal of the Association of Physicians of India, 2023, Volume: 71, Issue:1 Topics: Adenoma; Adrenocortical Adenoma; Aldosterone; Cardiomyopathies; Female; Humans; Hyperaldosteronism;	2023
Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness. Journal of hypertension, 2015, Volume: 33, Issue:4 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Aldosterone; Blood Pressure; Carotid I	2015
[Conn syndrome as cause of stubborn hypertension. Which hypertensives should you screen?]. MMW Fortschritte der Medizin, 2003, Feb-27, Volume: 145, Issue:9 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic beta-Antagonists; Aldosterone; Angiotens	2003
[PRIMARY ALDOSTERONISM (CONN SYNDROME)]. Der Internist, 1964, Volume: 5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Child; Diagnosis, Differential; Humans; Hyperaldost	1964
PRIMARY ALDOSTERONISM AND THE EFFECTS OF TWO MINERALOCORTICOID INHIBITORS--TRIAMTERENE AND SPIRONOLACTONE (ALDACTONE). Canadian Medical Association journal, 1964, May-16, Volume: 90 Topics: Adenoma; Adrenal Gland Neoplasms; Diuretics; Humans; Hyperaldosteronism; Mineralocorticoids; Patholo	1964
[FURTHER OBSERVATIONS ON CONN'S SYNDROME]. Casopis lekaru ceskych, 1964, Jan-31, Volume: 103 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Electrocardiography; Humans; Hyperaldosteronism; Hy	1964
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL ADENOMA IN A THREE-YEAR-OLD CHILD. Acta paediatrica, 1964, Volume: 53 Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Adenoma;	1964
PRIMARY ALDOSTERONISM: OBSERVATIONS IN SIX CASES AND REVIEW OF DIAGNOSTIC PROCEDURES. Medicine, 1964, Volume: 43 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Diabetes Mellitus; Diagnosis, Differen	1964
CATHETERIZATION OF THE LEFT ADRENAL VEIN FOR CONTRAST INJECTION AND STEROID ANALYSIS IN A CASE OF CONN'S SYNDROME. Acta medica Scandinavica, 1964, Volume: 176 Topics: 17-Ketosteroids; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Angiography; Blood;	1964
CONN'S SYNDROME WITH ASSOCIATED PREGNANCY. Proceedings of the Royal Society of Medicine, 1965, Volume: 58 Topics: Adenoma; Adrenal Gland Neoplasms; Blood; Dexamethasone; Diagnosis; Female; Humans; Hyperaldosteronis	1965
High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients. Journal of hypertension, 2003, Volume: 21, Issue:11 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aged; Aldosterone; Female; F	2003
High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients. Journal of hypertension, 2003, Volume: 21, Issue:11 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aged; Aldosterone; Female; F	2003
High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients. Journal of hypertension, 2003, Volume: 21, Issue:11 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aged; Aldosterone; Female; F	2003
High rate of detection of primary aldosteronism, including surgically treatable forms, after 'non-selective' screening of hypertensive patients. Journal of hypertension, 2003, Volume: 21, Issue:11 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aged; Aldosterone; Female; F	2003
Relative glomerular hyperfiltration in primary aldosteronism. Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:5 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aged; Blood Pressure; Female; Glomerular Filtration Rate;	2005
Diurnal blood pressure pattern in patients with primary aldosteronism. Journal of endocrinological investigation, 2006, Volume: 29, Issue:1 Topics: Adenoma; Adrenal Gland Diseases; Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circa	2006
Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in patients with primary aldosteronism. Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aldosterone; Antihypertensive Agents; Female; Follo	2007
Heterotopic adrenocortical adenoma producing primary aldosteronism. The Journal of urology, 1967, Volume: 98, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Diagnosis, Differential; Diet, Sodium-Restricted; Female; H	1967
In vitro responses of aldosterone-producing adenomas to angiotensin II and ACTH after treatment with spironolactone before adrenalectomy. The Journal of laboratory and clinical medicine, 1984, Volume: 104, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Aldosterone; Angiotens	1984
Primary aldosteronism with bilateral adrenal adenomas. Virchows Archiv. A, Pathological anatomy and histology, 1980, Volume: 388, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Aged; Female; Humans; Hyperaldosteronism; Inclusion Bodies; Neopla	1980
Normotensive primary aldosteronism: report of a case. The Journal of clinical endocrinology and metabolism, 1981, Volume: 52, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Angiotensin II	1981
Primary aldosteronism: effects of inhibition of ACTH and potassium administration on plasma aldosterone concentration. Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:9-10 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Aldoste	1982
[Spironolactone bodies. Light and electron microscope study apropos of 4 cases of adrenal adenomas with primary hyperaldosteronism]. Annales de pathologie, 1982, Volume: 2, Issue:4 Topics: Adenoma; Adrenal Cortex Neoplasms; Humans; Hyperaldosteronism; Inclusion Bodies; Microscopy, Electro	1982
Factors affecting the frequency of occurrence of spironolactone bodies in aldosteronomas and non-tumorous cortex. Pathology, 1983, Volume: 15, Issue:3 Topics: Adenoma; Adolescent; Adrenal Cortex; Adrenal Gland Neoplasms; Adult; Female; Humans; Hyperaldosteron	1983
Primary aldosteronism is comprised of primary adrenal hyperplasia and adenoma. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1984, Volume: 2, Issue:3 Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adult; Ag	1984
Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:9-10 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Angiotensin II; Female; Humans; Hypertension;	1982
Primary aldosteronism -- screening, diagnosis and therapy. Cor et vasa, 1981, Volume: 23, Issue:4 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Female; Humans; Hyperaldosteron	1981
Adrenal scintigraphy in primary aldosteronism. Spironolactone as a cause of incorrect classification between adenoma and hyperplasia. European journal of nuclear medicine, 1982, Volume: 7, Issue:5 Topics: 19-Iodocholesterol; Adenoma; Adosterol; Adrenal Gland Neoplasms; Adult; False Positive Reactions; Fe	1982
Spironolactone bodies in aldosteronomas and in the attached adrenals. Enzyme histochemical study of 19 cases of primary aldosteronism and a case of aldosteronism due to bilateral diffuse hyperplasia of the zona glomerulosa. The American journal of pathology, 1981, Volume: 103, Issue:3 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aldosterone; Animals; Female; Histocytochemistry; Humans;	1981
[Apropos of a case of Conn's disease. Use of computerized axial tomography in the differential diagnosis from hyperaldosteronism]. Revista de medicina de la Universidad de Navarra, 1981, Volume: 25, Issue:4 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Desoxycorticosterone; Dexamethasone; Diagnosis, Differentia	1981
[Adrenal aldosterone-producing adenoma: a diagnostic approach]. L'union medicale du Canada, 1980, Volume: 109, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Angiography; Circadian Rhythm; Diagno	1980
Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension. JAMA, 1980, Sep-19, Volume: 244, Issue:12 Topics: Adenoma; Adult; Aldosterone; Blood Pressure; Female; Humans; Hyperaldosteronism; Hyperparathyroidism	1980
Cushing's syndrome: problems in diagnosis. Medicine, 1981, Volume: 60, Issue:1 Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult;	1981
Primary aldosteronism. Current therapy in endocrinology and metabolism, 1994, Volume: 5 Topics: Adenoma; Adrenal Gland Neoplasms; Diagnosis, Differential; Glucocorticoids; Humans; Hyperaldosteroni	1994
Primary aldosteronism: difference in clinical presentation and long-term follow-up between adenoma and bilateral hyperplasia of the adrenal glands. The Clinical investigator, 1994, Volume: 72, Issue:12 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Diagnosis, Differential; Follow-Up St	1994
Aldosterone regulation in primary aldosteronism. European journal of endocrinology, 1994, Volume: 131, Issue:3 Topics: Adenoma; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Humans; Hyperaldosteronism; Spiro	1994
Factors influencing outcome of surgery for primary aldosteronism. Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aged; Blood Pressure; Female	1996
Medical management of aldosterone-producing adenomas. Annals of internal medicine, 1999, Jul-20, Volume: 131, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aged; Aldosterone; Antihypertensive Agents; Blood Pressure;	1999
[Factors for postoperative persistent hypertension in patients with aldosterone-producing adenoma]. Zhonghua wai ke za zhi [Chinese journal of surgery], 1997, Volume: 35, Issue:7 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Age Factors; Aldosterone; Female; Follow-Up Studies; Humans	1997
Medical management of aldosterone-producing adenomas. Annals of internal medicine, 2000, Apr-04, Volume: 132, Issue:7 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Humans; Hypertension; Mineralocorticoid Receptor Anta	2000
Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2000, Volume: 108, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood Glucose; Glucose Clamp Technique; Glucos	2000
Test and teach. Surgically correctable hypertension. Conn's syndrome and spironolactone bodies. Pathology, 2001, Volume: 33, Issue:4 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Aldosterone; Humans; Hyperaldosteronism; Hypertens	2001
[Secondary forms of hypertension. 5. Hypertension caused by Cushing syndrome and Conn's disease]. MMW Fortschritte der Medizin, 2002, Feb-28, Volume: 144, Issue:9 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Algorithms; Cushing Sy	2002
Spironolactone bodies in an adrenal adenoma. Archives of pathology, 1975, Volume: 99, Issue:8 Topics: Adenoma; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Endoplasmic Reticulum; H	1975
[A case of primary aldosteronism associated with spironolactone inclusions (author's transl)]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1975, Jun-10, Volume: 64, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Canrenoic Acid; Female; Humans; Hyperaldosteronism; Inclusi	1975
Plasma concentration of aldosterone, 18-hydroxy-deoxycorticosterone and cortisol in adrenal veins of patients with low-renin hypertension. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1977, Volume: 9, Issue:5 Topics: 18-Hydroxydesoxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropi	1977
Control of plasma aldosterone in a patient with Conn's syndrome before and during spironolactone medication. Klinische Wochenschrift, 1975, Apr-15, Volume: 53, Issue:8 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Female;	1975
Results of adrenal surgery in patients with hypertension, aldosterone excess, and low plasma renin concentration. British medical journal, 1975, Jan-18, Volume: 1, Issue:5950 Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Angiotensin II; Blood Pres	1975
The use of spironolactone for the diagnosis of primary aldosteronism. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1979, Volume: 62, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Female; Humans; Hyperaldosteronism; Male; Spironolactone	1979
The significance of elevated levels of plasma 18-hydroxycorticosterone in patients with primary aldosteronism. The Journal of clinical endocrinology and metabolism, 1979, Volume: 49, Issue:1 Topics: 18-Hydroxycorticosterone; Adenoma; Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Aldosteron	1979
[Plasma aldosterone and electrolytes in primary and secondard aldosteronism (author's transl)]. Medizinische Klinik, 1979, Sep-14, Volume: 74, Issue:37 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aldosterone; Ascites; Electrolytes; Female; Humans; Hypera	1979
The treatment of low-renin ("primary") hyperaldosteronism. American heart journal, 1978, Volume: 96, Issue:1 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Amiloride; Blood Pressure; Dexamethasone; Female;	1978
Adrenal scintigraphy in low renin essential hypertension. Clinical nuclear medicine, 1978, Volume: 3, Issue:7 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Glands; Adult; Blood Pressure; Dexamethasone; Female; Hum	1978
Volume-pressure relationships during development of mineralocorticoid hypertension in man. Circulation research, 1977, Volume: 40, Issue:5 Suppl 1 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Insufficiency; Blood Pressure; Blood Volume; Electrolytes;	1977
[The renin-angiotensin-aldosterone system in hypertensive patients. II. Diagnosis of primary hyperaldosteronism]. La Nouvelle presse medicale, 1977, Sep-10, Volume: 6, Issue:29 Topics: Adenoma; Adolescent; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Adult; Aldosterone; Blo	1977
Spironolactone-induced inhibition of aldosterone biosynthesis in primary aldosteronism: morphological and functional studies. Metabolism: clinical and experimental, 1977, Volume: 26, Issue:12 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Aldosterone; Humans; Hyperaldosteronism;	1977
Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. Endocrinology, 1976, Volume: 99, Issue:4 Topics: Adenoma; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Animals; Canrenoic Ac	1976
[Diagnosis and treatment of primary aldosteronism]. Zhonghua wai ke za zhi [Chinese journal of surgery], 1992, Volume: 30, Issue:11 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Female; Humans; Hyperaldosteronism; Hyperkalem	1992
Twenty-four year spironolactone therapy in an aged patient with aldosterone-producing adenoma. Acta endocrinologica, 1992, Volume: 126, Issue:2 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Aged; Aldosterone; Fe	1992
A case of testosterone-secreting adrenal cortical adenoma with spironolactone body-like inclusion. Acta pathologica japonica, 1990, Volume: 40, Issue:1 Topics: Acid Phosphatase; Adenoma; Adolescent; Adrenal Cortex Neoplasms; Female; Histocytochemistry; Humans;	1990
Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism. American journal of hypertension, 1990, Volume: 3, Issue:7 Topics: Adenoma; Administration, Oral; Adrenal Gland Neoplasms; Adult; Aldosterone; Corticosterone; Desoxyco	1990
Plasma atrial natriuretic peptide (ANP) in primary aldosteronism. Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1988, Volume: 87, Issue:9 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aldosterone; Atrial Natriuretic Factor; Fem	1988
Ultrastructural studies of adrenal adenoma causing primary aldosteronism. Virchows Archiv. A, Pathological anatomy and histopathology, 1985, Volume: 407, Issue:3 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Cell Nucleus; Endoplasmic Reticulum; Female; Humans; Hyper	1985
[Results of the surgical treatment of Conn's adenomas]. Archives des maladies du coeur et des vaisseaux, 1987, Volume: 80, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Female; Humans; Hyperaldosteronism; Hypertension; Male; Retrospect	1987
Pre-operative evaluation of the prognosis of hypertension in primary aldosteronism owing to adenoma. Acta endocrinologica, 1987, Volume: 116, Issue:2 Topics: Adenoma; Adult; Female; Humans; Hyperaldosteronism; Hypertension; Male; Middle Aged; Pituitary Neopl	1987
[Therapy of primary aldosteronism]. Deutsche medizinische Wochenschrift (1946), 1986, Sep-26, Volume: 111, Issue:39 Topics: Adenoma; Adrenal Cortex Diseases; Adrenal Cortex Neoplasms; Adrenalectomy; Carcinoma; Diagnosis, Dif	1986
Hypertension with aldosterone excess and low plasma-renin: preoperative distinction between patients with and without adrenocortical tumour. Lancet (London, England), 1970, Nov-14, Volume: 2, Issue:7681 Topics: Adenoma; Adolescent; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Age Fac	1970
Functional black adenoma of the adrenal cortex. A rare cause of primary aldosteronism. American journal of clinical pathology, 1974, Volume: 62, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Dexamethasone; Female; Histocytochemistry; Humans; Hyperald	1974
Measurement of rectal electrical potential difference as an instant screening-test for hyperaldosteronism. Lancet (London, England), 1970, Sep-26, Volume: 2, Issue:7674 Topics: Adenoma; Adrenal Gland Neoplasms; Ascites; Electrodes; Electrodiagnosis; Feces; Fludrocortisone; Hum	1970
Medical grand rounds from the University of Alabama Medical Center. Southern medical journal, 1969, Volume: 62, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Angiotensin II; Humans; Hyperaldosteronism; Hypertens	1969
Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess, and low plasma renin. British medical journal, 1972, Jun-24, Volume: 2, Issue:5816 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Aldosterone; Angiotensin II; Blood Pr	1972
Control of plasma aldosterone in primary aldosteronism: distinction between adenoma and hyperplasia. The Journal of clinical endocrinology and metabolism, 1973, Volume: 37, Issue:5 Topics: Adenoma; Adrenocorticotropic Hormone; Aldosterone; Circadian Rhythm; Dexamethasone; Diet; Female; Hu	1973
Spironolactone inclusions in an aldosteronoma. American journal of clinical pathology, 1974, Volume: 61, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Cytoplasmic Granules; Humans; Hyper	1974
Reduced aldosterone secretion during spironolactone treatment in primary aldosteronism: report of a case. The Journal of clinical endocrinology and metabolism, 1974, Volume: 39, Issue:4 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aldosterone; Blood Pressure; Choleste	1974
[A description of a case of Conn's syndrome (author's transl)]. Journal de radiologie, d'electrologie, et de medecine nucleaire, 1974, Volume: 55, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aortography; Female; Humans;	1974
Pitfalls in the surgery of aldosterone-producing tumors. American journal of surgery, 1972, Volume: 124, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Aldosterone; Female; Humans; Male; Middle Aged; Spironolact	1972
The diagnostic and therapeutic value of spironolactone in patients with systemic hypertension. Nephron, 1973, Volume: 9, Issue:3 Topics: Acid-Base Equilibrium; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood Press	1973
[Primary hyperaldosteronism with malignant hypertension]. La Nouvelle presse medicale, 1973, Feb-03, Volume: 2, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Blood Pressure Determination; Female; Humans	1973
Experience with primary aldosteronism. The Journal of urology, 1973, Volume: 110, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Female; Follow-Up Studies; Huma	1973
[Primary hyperaldosteronism: differentiation between adenoma and primary hyperplasia of the adrenal glands and operative indications]. La Presse medicale, 1971, Dec-18, Volume: 79, Issue:54 Topics: Adenoma; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Aldosterone; Dexamethasone; Diagnosis, Dif	1971
[Primary aldosteronism and its surgical treatment]. Khirurgiia, 1970, Volume: 46, Issue:5 Topics: Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aldosterone; Child; Female; Huma	1970
The syndrome of primary aldosteronism. The American journal of medicine, 1970, Volume: 48, Issue:3 Topics: 17-Hydroxycorticosteroids; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adult; Aldosterone; Blood U	1970
Management of aldosteronism. American journal of clinical pathology, 1970, Volume: 54, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aminoglutethimide; Humans; Hyperaldosteronism; Min	1970
[The spironolactone test at high dosage in the study of arterial hypertension with hyperaldosteronism]. Revista clinica espanola, 1971, Feb-28, Volume: 120, Issue:4 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Blood Pressure; Female; Humans; Hyperaldosteronism; Hyperte	1971
[Endocrinologic and circulatory findings in a case of primary aldosteronism]. Deutsche medizinische Wochenschrift (1946), 1971, May-28, Volume: 96, Issue:22 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Female; Hemodynamics; Humans; Hyperaldosteronism; Hyp	1971
Unilateral adrenalectomy for aldosteronomas localized preoperatively by differential adrenal vein catheterization. Surgery, 1968, Volume: 64, Issue:1 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Aldosterone; Angiography; Ao	1968
Test for pathologic secretion of aldosterone. JAMA, 1968, Nov-25, Volume: 206, Issue:9 Topics: Adenoma; Adrenal Gland Neoplasms; Aldosterone; Diet; Humans; Hyperaldosteronism; Hyperplasia; Hypert	1968
Conn's syndrome. A detailed study on corticoid metabolites in the urine in two operated cases. Acta medica Scandinavica, 1966, Volume: 179, Issue:2 Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; Blood Pressure Determination; Chro	1966
Primary aldosteronism due to adrenocortical adenoma (Conn's syndrome). South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1966, Nov-12, Volume: 40, Issue:41 Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Female; Humans; Hyperaldosteronism; Hypokalemia; Paralysis;	1966

spironolactone and Adenoma

Research Excerpts

Research

Studies (110)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Mandal, C	1
Dutta, PK	1
Holaj, R	1
Rosa, J	1
Zelinka, T	1
Štrauch, B	1
Petrák, O	1
Indra, T	1
Šomlóová, Z	1
Michalský, D	1
Novák, K	1
Wichterle, D	1
Widimský, J	2
Martínez, JJ	1
Oliveira, CL	1
Meneses, AL	1
Rodríguez, SA	1
Corrales, PP	1
López, AH	1
Romero, FB	1
Chambaz, IC	1
Pechère-Bertschi, A	1
Herpin, D	1
Sosner, P	1
Amar, J	1
Chamontin, B	1
Reincke, M	1
KOCZOREK, KR	1
ROBERTSON, GL	1
DAWSON, JW	1
OPATRNY, K	1
BARCAL, R	1
KARLICEK, V	1
SPINKA, J	1
RACEK, F	1
MINAR, J	1
CAVELL, B	1
HOEKFELT, B	2
LUETSCHER, JA	4
BUCHT, H	1
BERGSTROEM, J	1
LINDHOLMER, B	1
WIJNBLADH, H	1
BOUCHER, BJ	1
MASON, AS	1
Stowasser, M	1
Gordon, RD	2
Gunasekera, TG	1
Cowley, DC	1
Ward, G	1
Archibald, C	1
Smithers, BM	1
Al Fehaily, M	1
Duh, QY	1
Ribstein, J	1
Du Cailar, G	1
Fesler, P	1
Mimran, A	1
Zacharieva, S	1
Orbetzova, M	1
Elenkova, A	1
Stoynev, A	1
Yaneva, M	1
Schigarminova, R	1
Kalinov, K	1
Nachev, E	1
Nishikawa, T	1
Saito, J	1
Shibata, H	1
Catena, C	1
Colussi, G	1
Lapenna, R	1
Nadalini, E	1
Chiuch, A	1
Gianfagna, P	1
Sechi, LA	1
Auchus, RJ	1
Nwariaku, FE	1
Flanagan, MJ	1
McDonald, JH	1
Wisgerhof, M	1
Favre, L	1
Jacot-des-Combes, E	1
Morel, P	1
Hauser, H	1
Riondel, AM	1
Mégevand, R	1
Vallotton, MB	1
Kono, T	1
Ikeda, F	1
Oseko, F	1
Imura, H	1
Tanimura, H	1
Ganguly, A	3
Weinberger, MH	2
Vacher-Lavenu, MC	1
Lellouch-Tubiana, A	1
Louvel, A	1
Daudet-Monsac, M	1
Abelanet, R	1
Cohn, D	1
Jackson, RV	1
Biglieri, EG	4
Kater, CE	2
Arteaga, EE	1
Wambach, G	2
Helber, A	2
Bönner, G	2
Konrads, A	1
Hummerich, W	2
Meurer, KA	2
Kaufmann, W	2
Scoggins, BA	1
Coghlan, JP	1
Menon, M	1
Mersey, JH	1
Horký, K	2
Gregorová, I	2
Vancura, J	2
Silinková-Málková, E	2
Hradec, E	1
Schalekamp, MA	1
Wenting, GJ	1
Man in 't Veld, AJ	2
Fischer, M	1
Vetter, W	3
Winterg, B	1
Zidek, W	1
Vetter, H	2
Aiba, M	1
Suzuki, H	2
Kageyama, K	1
Murai, M	2
Tazaki, H	2
Abe, O	1
Saruta, T	2
Cabarcos, A	1
Arrieta, J	1
Damiano, A	1
Quiroga, J	1
Esteban, L	1
Yagüe, S	1
Ouimet, D	1
Houde, M	2
Hellman, DE	1
Kartchner, M	1
Komar, N	1
Mayes, D	1
Pitt, M	1
Aron, DC	1
Tyrrell, JB	1
Fitzgerald, PA	1
Findling, JW	1
Forsham, PH	1
Jeck, T	1
Weisser, B	1
Mengden, T	1
Erdmenger, L	1
Grüne, S	1
Mantero, F	1
Celen, O	1
O'Brien, MJ	1
Melby, JC	2
Beazley, RM	1
Ghose, RP	1
Hall, PM	1
Bravo, EL	1
Liu, D	1
Zheng, C	1
Chen, Q	1
Ferriss, JB	6
Sindelka, G	1
Haas, T	1
Prázný, M	1
Hilgertová, J	1
Skrha, J	1
Plouin, PF	2
Massien-Simon, C	1
Al Saad, KO	1
Chan, NH	1
Füessl, HS	1
Melada, GA	2
Dowdy, AJ	2
Shrago, SS	1
Waisman, J	1
Cooper, PH	1
Sasaki, J	1
Fukuma, M	1
Chisaka, E	1
Kashiwagi, S	1
Imamura, T	1
Tomsová, Z	1
Brown, JJ	5
Fraser, R	5
Haywood, E	2
Davies, DL	3
Kay, AW	2
Lever, AF	5
Robertson, JI	5
Owen, K	1
Peart, WS	1
McGuffin, WL	1
Gunnells, JC	1
Ibayashi, H	1
Takasugi, M	1
Himathongkam, T	1
Kaojarern, S	1
Shaipanich, T	1
Israngkul, W	1
Schambelan, M	1
Albert, JP	1
Wronski, R	1
Jentzen, F	1
Hartmann, F	1
Beevers, DG	2
Boddy, K	1
Kremer, D	1
Rifai, A	1
Beierwaltes, WH	1
Freitas, JE	1
Grekin, R	1
Wenting, GH	1
Verhoeven, RP	1
Derkx, FH	1
Schalekamp, DH	1
Corvol, P	2
Benguigui, L	1
Tonnelier, M	1
Menard, J	2
Milliez, P	2
Conn, JW	1
Hinerman, DL	1
Cheng, SC	1
Suzuki, K	1
Sadee, W	1
Harding, BW	1
Wang, GY	1
Takeda, R	1
Yamazaki, T	1
Ito, Y	1
Koshida, H	1
Morise, T	1
Miyamori, I	1
Hashimoto, T	1
Morimoto, S	1
Deng, Y	1
Osamura, Y	1
Tanaka, M	1
Katsuoka, Y	1
Kawamura, N	1
Murakoshi, M	1
Sakamoto, H	1
Ichikawa, S	1
Sakamaki, T	1
Nakamura, T	1
Ono, Z	1
Takayama, Y	1
Murata, K	1
Irony, I	1
Shackleton, CH	1
Chen, JH	1
Tsai, JH	1
Lai, YH	1
Hwang, SJ	1
Kuramoto, H	1
Kumazawa, J	1
Pagny, JY	1
Chatellier, G	1
Duclos, JM	1
Takita, T	1
Saito, I	1
Stimpel, M	1
Dralle, H	1
von zur Mühlen, A	1
Drury, PL	1
Neville, AM	1
O'Muircheartaigh, IG	1
Symington, T	1
Caplan, RH	1
Virata, RL	1
Edmonds, CJ	1
Richards, P	1
Hardin, JG	1
Coker, AS	1
Blanton, JH	1
Horton, R	1
Cain, DR	1
Van de Velde, RL	1
Shapiro, SJ	1
Sundsfjord, JA	1
Marton, P	1
Jorgensen, H	1
Aakvaag, A	1
Martin, PL	1
Dallocchio, M	1
Fourcade, JP	1
Clémenty, J	1
Coqueran, J	1
Choussat, A	1
Bricaud, H	1
Donohue, JP	1
Kaplan, NN	1
Ripa, R	1
Mannix, H	1
Ackerman, NB	1
Johnson-Giannopoulos, N	1
Winer, N	1
Burden, RP	1
Booth, LJ	1
Aber, GM	1
Baglin, A	1
Weiss, Y	1
Safar, M	1
Tremann, JA	1
Gibbons, RP	1
Correa, RJ	1
Kaplan, NM	1
Fournier, A	1
Nikolaev, OV	1
Gerasimenko, PP	1
Kertsman, VI	1
Kalinin, AP	1
George, JM	1
Wright, L	1
Bell, NH	1
Bartter, FC	1
Liddle, GW	1
Caralps, A	1
Gil-Vernet, JM	1
Brulles, A	1
García-Jiménez, J	1
Permanyer, J	1
Marsen, B	1
Dissmann, T	1
Oelkers, W	1
Lohmann, FW	1
Molzahn, M	1
Gotzen, R	1
Egdahl, RH	1
Kahn, PC	1
Birchall, R	1
Batson, HM	1
Lorenzen, I	1
Damkjaer Nielsen, M	1
Nordentoft, EL	1
Stein, L	1
Shapiro, N	1
Stein, D	1