spironolactone has been researched along with Addison Disease in 13 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| STEINMAN, AM | 1 |
| BROWN, JJ | 1 |
| DAVIES, DL | 1 |
| LEVER, AF | 1 |
| ROBERTSON, JI | 1 |
| STUDER, H | 1 |
| GAUTIER, E | 1 |
| SCHMID, A | 1 |
| LAMBERG, BA | 1 |
| TORSTI, P | 1 |
| Abshagen, U | 1 |
| Spörl, S | 1 |
| Schöneshöfer, M | 1 |
| Oelkers, W | 1 |
| Sutanto, W | 1 |
| de Kloet, ER | 1 |
| Richards, P | 1 |
| Melby, JC | 1 |
| Koczorek, KR | 1 |
| Avenhaus, H | 1 |
| Wood, LC | 1 |
| Richards, R | 1 |
| Ingbar, SH | 1 |
| Shioji, R | 1 |
| Rikimaru, S | 1 |
| Ito, H | 1 |
| Panzram, G | 1 |
| Kautzsch, G | 1 |
| Streeten, DH | 1 |
| Speller, PJ | 1 |
2 reviews available for spironolactone and Addison Disease
| Article | Year |
|---|---|
Mineralocorticoid receptor ligands: biochemical, pharmacological, and clinical aspects.
Topics: Addison Disease; Adrenal Cortex Hormones; Animals; Brain Chemistry; Canrenone; Drug Design; Hippocam | 1991 |
Assessment of adrenocortical function.
Topics: 17-Ketosteroids; Addison Disease; Adolescent; Adrenal Glands; Adrenal Insufficiency; Adult; Aldoster | 1971 |
11 other studies available for spironolactone and Addison Disease
| Article | Year |
|---|---|
Mechanism of action and use of aldosterone-blocking steroids in edema.
Topics: Addison Disease; Adrenal Insufficiency; Aldosterone; Edema; Humans; Hypoadrenocorticism, Familial; S | 1962 |
VARIATIONS IN PLASMA RENIN CONCENTRATION IN SEVERAL PHYSIOLOGICAL AND PATHOLOGICAL STATES.
Topics: Addison Disease; Aldosterone; Angiotensins; Blood Chemical Analysis; Hypertension; Hypokalemia; Live | 1964 |
[THE EFFECT OF MINERALOCORTICOIDS ON THE DILUTION AND CONCENTRATION MECHANISMS OF THE KIDNEY].
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Humans; Hypoadrenoco | 1964 |
THE DEPENDENCE OF CALCIUM EXCRETION ON ADRENAL STEROIDS. STUDIES WITH CHLOROTHIAZIDE IN PATIENTS WITH IMPAIRED ADRENAL FUNCTION.
Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenalectomy; Blo | 1964 |
Increased plasma 11-deoxycorticosterone during spironolactone medication.
Topics: Addison Disease; Desoxycorticosterone; False Positive Reactions; Humans; Male; Radioimmunoassay; Spi | 1977 |
Clinical investigation of the effects of adrenal corticosteroid excess on the colon.
Topics: Addison Disease; Adrenal Cortex Hormones; Adrenocortical Hyperfunction; Adult; Aldosterone; Colon; C | 1969 |
[The influence of aldosterone and aldosterone antagonists on the pressor effect of synthetic Angiotensin II in primary chronic adrenal cortex insufficiency (M. Addison)].
Topics: Addison Disease; Adult; Aldosterone; Angiotensin II; Blood Pressure; Glucocorticoids; Humans; Male; | 1966 |
Interference in the measurement of plasma 11-hydroxycorticosteroids caused by spironolactone administration.
Topics: 17-Ketosteroids; Addison Disease; Adrenal Cortex Hormones; Adult; Aged; False Positive Reactions; Fl | 1970 |
Urinary citrate excretion in primary aldosteronism.
Topics: Addison Disease; Adult; Aldosterone; Carbon Dioxide; Citrates; Desoxycorticosterone; Dexamethasone; | 1967 |
[Modification of sweat electrolytes by spirolactones in secondary hyperaldosteronism].
Topics: Addison Disease; Diet, Sodium-Restricted; Humans; Hyperaldosteronism; Liver Cirrhosis; Potassium; So | 1965 |
The role of aldosterone and vasopressin in the postural changes in renal excretion in normal subjects and patients with idiopathic edema.
Topics: Addison Disease; Adolescent; Adrenalectomy; Adult; Aldosterone; Creatine; Dextroamphetamine; Diabete | 1966 |