Compounds > spironolactone
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spironolactone and Acute Liver Injury, Drug-Induced

spironolactone has been researched along with Acute Liver Injury, Drug-Induced in 24 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Research Excerpts

ExcerptRelevanceReference
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"Treatment with spironolactone, pregnenolone-16_-carbonitrile or triamcinolone reduced only slightly SGPT and triglycerides, but restored the reduced resistance to drugs, and the impairment of the liver drug metabolism in vitro."1.28Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents. ( Kourounakis, PN; Rekka, E, 1991)
" Dose-related increases in thyroid-stimulating hormone (TSH) levels were observed in treated animals of both sexes during the dosing period and the changes were statistically significant and correlated with an increased thyroid weight in females at 13 weeks."1.27The pathologic response of the liver and thyroid of the rat to potassium prorenoate (SC-23992). ( Lumb, GD; Rust, JH, 1985)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199014 (58.33)18.7374
1990's3 (12.50)18.2507
2000's1 (4.17)29.6817
2010's6 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Ding, D1
Kelly, R1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
CASCIO, G1
PALAZZOADRIANO, M1
Shuck, J1
Shen, S1
Owensby, L1
Leftik, M1
Cucinell, S1
Renkes, P1
Gaucher, P1
Tréchot, P1
Thai, KE1
Sinclair, RD1
Bjondahl, K1
Bossone, CM1
Hecht, Y1
Rigaud, D1
Celerier, M1
Leclerc, JP1
Ferrier, JP1
Abshagen, U1
Rennekamp, H1
Luszpinski, G1
Salas, M1
Tuchweber, B1
Kuntz, E1
Kourounakis, PN1
Rekka, E1
Iacona, A1
Rossetti, A1
Filingeri, V1
Orsini, D1
Cesarini, A1
Cervelli, V1
Adorno, D1
Casciani, CU1
Lumb, GD1
Rust, JH1
Carlson, GP1
Fuller, GC1
Fausto, N1
Ilinich, VK1
Plastun, FF1
Lazar, G1
Szabo, S1
Husztik, E1
Mansurova, ID1
Chernyshov, VG1
Stosman, RZ1
Taft, LI1

Reviews

2 reviews available for spironolactone and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
[Treatment of acute hepatic insufficiency (a survey of the literature)].
    Voenno-meditsinskii zhurnal, 1972, Volume: 12

    Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr

1972

Other Studies

22 other studies available for spironolactone and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
[PHARMACOLOGICAL ACTIONS OF 2 HETEROCYCLIC GLYOXYLIC ALDEHYDES WITH NOTABLE DIURETIC ACTIVITY].
    Il Farmaco; edizione scientifica, 1964, Volume: 19

    Topics: Aldehydes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorothiazide; C

1964
Spironolactone hepatitis in primary hyperaldosteronism.
    Annals of internal medicine, 1981, Volume: 95, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hyperaldosteronism; Liver; Middle Aged; Spir

1981
Spironolactone and hepatic toxicity.
    JAMA, 1995, Feb-01, Volume: 273, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Male; Spironolactone

1995
Spironolactone-induced hepatitis.
    The Australasian journal of dermatology, 2001, Volume: 42, Issue:3

    Topics: Alopecia; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Middle Aged;

2001
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:5

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver

1978
The liver: a pharmacologic perspective.
    The Nursing clinics of North America, 1977, Volume: 12, Issue:2

    Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec

1977
[Cholestatic hepatitis due to ajmaline. Lymphatic congestion of the liver. Recovery after spironolactone].
    Medecine & chirurgie digestives, 1978, Volume: 7, Issue:6

    Topics: Ajmaline; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Middle Aged; Spironol

1978
Disposition kinetics of spironolactone in hepatic failure after single doses and prolonged treatment.
    European journal of clinical pharmacology, 1977, Mar-11, Volume: 11, Issue:3

    Topics: Adult; Chemical and Drug Induced Liver Injury; Half-Life; Humans; Kinetics; Liver Cirrhosis; Liver D

1977
Prevention by steroids of cerium hepatotoxicity.
    Archives of toxicology, 1976, Mar-11, Volume: 35, Issue:2

    Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estra

1976
[Edematous hepatitis: a special form of acute virus hepatitis with secondary aldosteronism (author's transl)].
    Medizinische Klinik, 1975, Feb-14, Volume: 70, Issue:7

    Topics: Adult; Aldosterone; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Edema; Female;

1975
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
    European journal of drug metabolism and pharmacokinetics, 1991, Volume: Spec No 3

    Topics: Alanine Transaminase; Animals; Arthritis, Experimental; Chemical and Drug Induced Liver Injury; Fema

1991
Reduced nephrotoxicity and hepatoxicity in cyclosporin A therapy by enalapril and spironolactone in rats.
    Drugs under experimental and clinical research, 1991, Volume: 17, Issue:10-11

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Drug Therapy, Combination; Enalapril;

1991
The pathologic response of the liver and thyroid of the rat to potassium prorenoate (SC-23992).
    Toxicologic pathology, 1985, Volume: 13, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Female; Lethal Dose 50; Liver; Male; Microsom

1985
Effects of spironolactone on carbon tetrachloride hepatotoxicity.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 145, Issue:1

    Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisonin

1974
The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1972, Volume: 159, Issue:1

    Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Chemical and Drug Induced Liver Injury; Ethylestren

1972
[Effect of CC1-4 and aldactone on the activity of acid hydrolases and deamination enzymes in rat liver].
    Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 76, Issue:9

    Topics: Acid Phosphatase; Aminohydrolases; Ammonia-Lyases; Animals; Carbon Tetrachloride Poisoning; Chemical

1973
Methotrexate induced hepatitis in childhood leukemia.
    Israel journal of medical sciences, 1965, Volume: 1, Issue:4

    Topics: Aminopterin; Biopsy; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans

1965