Page last updated: 2024-11-07

spironolactone and Active Hyperemia

spironolactone has been researched along with Active Hyperemia in 1 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Research Excerpts

ExcerptRelevanceReference
"In a dosage of 50 mg bid, eplerenone does not augment extracellular adenosine formation in healthy human subjects."2.79The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study. ( Bilos, A; Deinum, J; Donders, AR; Riksen, NP; Rongen, GA; van den Berg, TN, 2014)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
van den Berg, TN1
Deinum, J1
Bilos, A1
Donders, AR1
Rongen, GA1
Riksen, NP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of the Selective Mineralocorticoid Receptor Antagonist Eplerenone on Extracellular Adenosine Formation in Humans in Vivo[NCT01837108]Phase 414 participants (Actual)Interventional2013-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for spironolactone and Active Hyperemia

ArticleYear
The effect of eplerenone on adenosine formation in humans in vivo: a double-blinded randomised controlled study.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adenosine; Caffeine; Dipyridamole; Double-Blind Method; Eplerenone; Forearm; Hemodynamics; Humans; H

2014