spironolactone has been researched along with Acquired Nephrogenic Diabetes Insipidus in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone treatment of rats with Li-NDI decreased fractional excretion of sodium (0." | 1.33 | Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD. ( Frøkiaer, J; Knepper, MA; Kwon, TH; Nielsen, J; Nielsen, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FRIIS-HANSEN, B | 1 |
| SKADHAUGE, E | 1 |
| ZETTERSTROEM, R | 1 |
| Nielsen, J | 1 |
| Kwon, TH | 1 |
| Frøkiaer, J | 1 |
| Knepper, MA | 1 |
| Nielsen, S | 1 |
2 other studies available for spironolactone and Acquired Nephrogenic Diabetes Insipidus
| Article | Year |
|---|---|
FLUID AND ELECTROLYTE METABOLISM IN NEPHROGENIC DIABETES INSIPIDUS.TWO CASES.
Topics: Bendroflumethiazide; Child; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diabetes Insipidus, | 1963 |
Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD.
Topics: Aldosterone; Animals; Antimanic Agents; Diabetes Insipidus, Nephrogenic; Epithelial Sodium Channels; | 2006 |