spironolactone has been researched along with Acidosis in 21 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six patients with alcoholic cirrhosis developed a reversible metabolic acidosis during treatment with the aldosterone antagonist spironolactone." | 7.66 | Spironolactone-induced hyperchloremic acidosis in cirrhosis. ( Gabow, PA; Moore, S; Schrier, RW, 1979) |
| "Six patients with alcoholic cirrhosis developed a reversible metabolic acidosis during treatment with the aldosterone antagonist spironolactone." | 3.66 | Spironolactone-induced hyperchloremic acidosis in cirrhosis. ( Gabow, PA; Moore, S; Schrier, RW, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wesson, DE | 1 |
| Simoni, J | 1 |
| Pickering, W | 1 |
| Cheng, MK | 1 |
| Brown, J | 1 |
| Butler, H | 1 |
| Walls, J | 1 |
| Bevington, A | 1 |
| BAGROS, P | 1 |
| DETTLI, L | 1 |
| SPRING, P | 1 |
| Fujii, M | 1 |
| Suto, H | 1 |
| Goto, M | 1 |
| Miki, Y | 1 |
| Asai, N | 1 |
| Eaves, ER | 1 |
| Korman, MG | 1 |
| Zapater, P | 1 |
| Alba, D | 1 |
| Nolan, PJ | 1 |
| Knepper, MA | 1 |
| Packer, RK | 1 |
| Henger, A | 1 |
| Tutt, P | 1 |
| Riesen, WF | 1 |
| Hulter, HN | 1 |
| Krapf, R | 1 |
| Gabow, PA | 1 |
| Moore, S | 1 |
| Schrier, RW | 1 |
| Nierenberg, DW | 1 |
| Feinfeld, DA | 1 |
| Carvounis, CP | 1 |
| Kushner, RF | 1 |
| Sitrin, MD | 1 |
| Raynaud, R | 1 |
| Brochier, M | 1 |
| Raynaud, P | 1 |
| Fauchier, JP | 1 |
| Gross, W | 1 |
| Wagner, J | 1 |
| Bartels, O | 1 |
| Spitzer, A | 1 |
| Edelmann, CM | 1 |
| Goldberg, LD | 1 |
| Henneman, PH | 1 |
| Mashford, ML | 1 |
| Robertson, MB | 1 |
| Griggs, RC | 1 |
| Engel, WK | 1 |
| Resnick, JS | 1 |
| Lenzi, F | 1 |
| Suzuki, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity[NCT02896309] | 45 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for spironolactone and Acidosis
| Article | Year |
|---|---|
Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness.
Topics: Acetazolamide; Acidosis; Adult; Child; Electrolytes; Female; Humans; Hypokalemia; Male; Middle Aged; | 1970 |
20 other studies available for spironolactone and Acidosis
| Article | Year |
|---|---|
Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Topics: Acid-Base Equilibrium; Acidosis; Administration, Oral; Aldosterone; Animals; Bicarbonates; Calcium G | 2010 |
Stimulation of protein degradation by low pH in L6G8C5 skeletal muscle cells is independent of apoptosis but dependent on differentiation state.
Topics: Acidosis; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Creatine Kinase; Culture Media, | 2003 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
[DIURETIC EFFECT OF THE SIMULTANEOUS COMBINATION OF DIURETIC SALT WITH A CARBONIC ANHYDRASE INHIBITOR].
Topics: Acetazolamide; Acidosis; Alkalosis; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Diuretics; D | 1964 |
[Water-electrolyte imbalance: Reality in diagnosis and therapy (discussion)].
Topics: Acid-Base Equilibrium; Acidosis; Diagnosis, Differential; Extracellular Fluid; Humans; Hypercalcemia | 2006 |
Cholestyramine induced hyperchloremic metabolic acidosis.
Topics: Acidosis; Aged; Chlorides; Cholestyramine Resin; Female; Humans; Hydrogen-Ion Concentration; Liver C | 1984 |
Acidosis and extreme hyperkalemia associated with cholestyramine and spironolactone.
Topics: Acidosis; Cholestyramine Resin; Humans; Hyperkalemia; Hypertension, Portal; Liver Cirrhosis, Alcohol | 1995 |
Role of adrenal steroids in stimulating ammonium excretion during acute metabolic acidosis.
Topics: Acidosis; Adrenal Cortex Hormones; Adrenal Glands; Ammonium Chloride; Animals; Corticosterone; Hormo | 1997 |
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic D | 2000 |
Spironolactone-induced hyperchloremic acidosis in cirrhosis.
Topics: Acidosis; Adult; Aged; Bicarbonates; Chlorides; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Mi | 1979 |
Spironolactone and metabolic acidosis.
Topics: Acidosis; Aged; Ascites; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Spironolactone | 1979 |
Fatal hyperkalemia and hyperchloremic acidosis. Association with spironolactone in the absence of renal impairment.
Topics: Acidosis; Ascites; Chlorine; Humans; Hyperkalemia; Male; Middle Aged; Mineralocorticoid Receptor Ant | 1978 |
Metabolic acidosis. Development in two patients receiving a potassium-sparing diuretic and total parenteral nutrition.
Topics: Acidosis; Adult; Aged; Electrolytes; Female; Humans; Kidney; Parenteral Nutrition, Total; Spironolac | 1986 |
[Hyperkalemias in cardiac patients].
Topics: Acidosis; Acute Kidney Injury; Adult; Aged; Arrhythmias, Cardiac; Digitalis Glycosides; Diuretics; F | 1974 |
[Effect of intravenous aldactone administration on cations and acid-base equilibrium].
Topics: Acid-Base Equilibrium; Acidosis; Blood Glucose; Cations, Monovalent; Hematocrit; Humans; Potassium; | 1972 |
[Emergency therapy in manifested shock].
Topics: Acidosis; Adrenal Cortex Hormones; Bicarbonates; Capillary Permeability; Emergencies; Heart Massage; | 1973 |
Short stature, hyperkalemia and acidosis: A defect in renal transport of potassium.
Topics: Acidosis; Bicarbonates; Child; Chlorothiazide; Dwarfism; Humans; Hyperkalemia; Male; Mineralocortico | 1973 |
Spironolactone and ammonium and potassium chloride.
Topics: Acidosis; Ammonium Chloride; Drug Interactions; Female; Heart Failure; Humans; Middle Aged; Potassiu | 1972 |
[Changes in the acid-base equilibrium in cardiac insufficiency].
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Alkalosis; Bicarbonates; Heart Diseases; Hea | 1967 |
[Diuretic action of the fruit of Catalpa ovata G. DON].
Topics: Acidosis; Actinium; Adrenalectomy; Alkalosis; Aminophylline; Ammonium Chloride; Animals; Carboxy-Lya | 1968 |