spironolactone has been researched along with Absence Seizure in 14 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "The antiseizure effect of tested combinations was not sex-dependent and not reversed by hydrocortisone pretreatment." | 5.33 | Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| " Here, tonic-clonic seizures were induced with a convulsive dose of pentylenetetrazole (PTZ), and acute seizure recurrence was evoked with a subconvulsive dose of the drug." | 3.76 | Stress within the postseizure time window inhibits seizure recurrence. ( Cao, J; Duan, TT; Mao, RR; Tan, JW; Tian, M; Xu, L; Zhou, QX, 2010) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "With a long (60 min) stress-KA delay, seizures were suppressed through activation of a glucocorticosterone receptor (GR)." | 1.38 | Stress and corticosteroid modulation of seizures and synaptic inhibition in the hippocampus. ( Maggio, N; Segal, M, 2012) |
| "The antiseizure effect of tested combinations was not sex-dependent and not reversed by hydrocortisone pretreatment." | 1.33 | Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "Both convulsion susceptibility and plasma corticosteroid levels display circadian rhythmicity." | 1.29 | Sensitivity of the circadian rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor binding. ( Keith, LD; Roberts, AJ, 1994) |
| "Development of seizures, but not of interictal phenomena, could be prevented by intravenous application of Diazepam (1 mg), Nembutal (30 mg/kg) and--less effectively--by Phenhydane (20 mg/kg)." | 1.25 | The effects of a spirolactone derivative on EEG and cortical single unit activity in the cat. ( Schick, F; Straschill, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, QX | 1 |
| Mao, RR | 1 |
| Duan, TT | 1 |
| Tan, JW | 1 |
| Tian, M | 1 |
| Cao, J | 1 |
| Xu, L | 1 |
| Maggio, N | 1 |
| Segal, M | 1 |
| Borowicz, KK | 2 |
| Czuczwar, SJ | 2 |
| Edwards, HE | 1 |
| Vimal, S | 1 |
| Burnham, WM | 1 |
| Roberts, AJ | 1 |
| Keith, LD | 1 |
| Straschill, M | 1 |
| Schick, F | 1 |
| Ueda, M | 1 |
| Bures, J | 1 |
| Selye, H | 4 |
| Szabo, S | 1 |
| Mécs, I | 1 |
| Platt, D | 1 |
| Luboeinski, MP | 1 |
| Norwig, P | 1 |
| Dieker, P | 1 |
| Buck, SH | 1 |
| Lage, GL | 1 |
| Solymoss, B | 1 |
| Toth, S | 1 |
| Varga, S | 1 |
14 other studies available for spironolactone and Absence Seizure
| Article | Year |
|---|---|
Stress within the postseizure time window inhibits seizure recurrence.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Anticonvulsants; Circadian Rhythm; Corticos | 2010 |
Stress and corticosteroid modulation of seizures and synaptic inhibition in the hippocampus.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Biophysics; Disease Models, Animal; Drug Interactions | 2012 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats.
Topics: Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Dru | 2005 |
The acute anticonvulsant effects of deoxycorticosterone in developing rats: role of metabolites and mineralocorticoid-receptor responses.
Topics: Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inh | 2005 |
Sensitivity of the circadian rhythm of kainic acid-induced convulsion susceptibility to manipulations of corticosterone levels and mineralocorticoid receptor binding.
Topics: Animals; Circadian Rhythm; Corticosterone; Hippocampus; Kainic Acid; Male; Mice; Mineralocorticoid R | 1994 |
The effects of a spirolactone derivative on EEG and cortical single unit activity in the cat.
Topics: Administration, Topical; Animals; Cats; Cerebral Cortex; Dose-Response Relationship, Drug; Electroen | 1975 |
Differential effects of cortical speading depression on epileptic foci induced by various convulsants.
Topics: Animals; Cerebral Cortex; Convulsants; Cortical Spreading Depression; Electroencephalography; Male; | 1977 |
Resistance to picrotoxin poisoning induced by catatoxic steroids.
Topics: Anabolic Agents; Androstanes; Animals; Cholesterol; Desoxycorticosterone; Ethylestrenol; Female; Flu | 1970 |
Protection by catatoxic steroids and related compounds against proscillaridin intoxication.
Topics: Anabolic Agents; Androstanes; Animals; Bufanolides; Digitoxin; Ethylestrenol; Female; Glucocorticoid | 1972 |
Influence on application and dosis on the effect of aldadiene-K on the rat brain.
Topics: Animals; Brain; Glucuronidase; Glycoside Hydrolases; Injections, Intraperitoneal; Liver; Lyases; Lys | 1972 |
Possible mechanism of the prevention of digitoxin toxicity by spironolactone in the mouse.
Topics: Animals; Digitoxin; Drug Antagonism; Enzyme Induction; Liver; Male; Mice; Paralysis; Pentobarbital; | 1971 |
Effect of catatoxic steroids upon established morbid changes.
Topics: Animals; Digitoxin; Female; Indomethacin; Intestine, Small; Nitriles; Peritonitis; Poisoning; Pregne | 1971 |
Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes, | 1971 |