spironolactone has been researched along with Abnormalities, Drug-Induced in 5 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone, which has been shown to have antiandrogen action in mature male rats, was given to pregnant rats from day 14 of pregnancy until delivery in a dose equivalent to the 400-mg adult human regimen." | 3.65 | Lack of effect of spironolactone on male genital development. ( Reckler, JM; Regestein, Q; Rose, LI, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ragmanauskaite, L | 1 |
| Kahn, B | 1 |
| Ly, B | 1 |
| Yeung, H | 1 |
| Molinatti, GM | 2 |
| Rose, LI | 1 |
| Regestein, Q | 1 |
| Reckler, JM | 1 |
| Seassaro, E | 1 |
| Pellegrini, R | 1 |
1 review available for spironolactone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Acne and the Lesbian, Gay, Bisexual, or Transgender Teenager.
Topics: Abnormalities, Drug-Induced; Acne Vulgaris; Adolescent; Androgen Antagonists; Androgens; Contracepti | 2020 |
4 other studies available for spironolactone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
[Can the anti-androgenic effect of spironolactone contraindicate its use in pregnancy?].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Female; Fetus; Genitalia, Male; Hirsutism; | 1980 |
[Can the anti-androgenic effect of spironolactone contraindicate its use in pregnancy?].
Topics: Abnormalities, Drug-Induced; Androgen Antagonists; Androgens; Animals; Female; Fetus; Genitalia, Mal | 1980 |
Lack of effect of spironolactone on male genital development.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Genitalia, Male; Hypospadias; Male; Pregnancy; | 1975 |
[Experimental study on teratology of spironolactone].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lung Diseases; Male; Mice; Pregnancy; Pregnancy | 1969 |